Search Results - "Cross, M. A."

Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites by Siegel, Tim Nicolai, Hekstra, Doeke R, Wang, Xuning, Dewell, Scott, Cross, George A.M

“…Transcription of protein-coding genes in trypanosomes is polycistronic and gene expression is primarily regulated by post-transcriptional mechanisms. Sequence…”
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Developmental Progression to Infectivity in Trypanosoma brucei Triggered by an RNA-Binding Protein by Kolev, Nikolay G., Ramey-Butler, Kiantra, Cross, George A. M., Ullu, Elisabetta, Tschudi, Christian

“…Unraveling the intricate interactions between Trypanosoma brucei, the protozoan parasite causing African trypanosomiasis, and the tsetse (Glossina) vector…”
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A Conserved DNA Repeat Promotes Selection of a Diverse Repertoire of Trypanosoma brucei Surface Antigens from the Genomic Archive by Hovel-Miner, Galadriel, Mugnier, Monica R, Goldwater, Benjamin, Cross, George A M, Papavasiliou, F Nina

“…African trypanosomes are mammalian pathogens that must regularly change their protein coat to survive in the host bloodstream. Chronic trypanosome infections…”
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MCM-BP is required for repression of life-cycle specific genes transcribed by RNA polymerase I in the mammalian infectious form of Trypanosoma brucei by Kim, Hee-Sook, Park, Sung Hee, Günzl, Arthur, Cross, George A M

“…Trypanosoma brucei variant surface glycoprotein (VSG) expression is a classic example of allelic exclusion. While the genome of T. brucei contains >2,000 VSG…”
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A histone methyltransferase modulates antigenic variation in African trypanosomes by Figueiredo, Luisa M, Janzen, Christian J, Cross, George A M

“…To evade the host immune system, several pathogens periodically change their cell-surface epitopes. In the African trypanosomes, antigenic variation is…”
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Telomere length affects the frequency and mechanism of antigenic variation in Trypanosoma brucei by Hovel-Miner, Galadriel A, Boothroyd, Catharine E, Mugnier, Monica, Dreesen, Oliver, Cross, George A M, Papavasiliou, F Nina

“…Trypanosoma brucei is a master of antigenic variation and immune response evasion. Utilizing a genomic repertoire of more than 1000 Variant Surface…”
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Epigenetic regulation in African trypanosomes: a new kid on the block by Figueiredo, Luisa M, Cross, George A. M, Janzen, Christian J

“…Key Points Trypanosoma brucei , the causative agent of sleeping sickness in humans, diverged from the highest eukaryotic lineage several hundred million years…”
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Nucleosomes Are Depleted at the VSG Expression Site Transcribed by RNA Polymerase I in African Trypanosomes by Figueiredo, Luisa M, Cross, George A M

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A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei by Leonova, Tatyana, Ly, K. Ina, Dreesen, Oliver, Papavasiliou, F. Nina, Boothroyd, Catharine E, Figueiredo, Luisa M, Cross, George A. M

“…Trypanosoma brucei is the causative agent of African sleeping sickness in humans and one of the causes of nagana in cattle. This protozoan parasite evades the…”
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Gene expression in Trypanosoma brucei : lessons from high-throughput RNA sequencing by Siegel, T. Nicolai, Gunasekera, Kapila, Cross, George A.M, Ochsenreiter, Torsten

“…Trypanosoma brucei undergoes major biochemical and morphological changes during its development from the bloodstream form in the mammalian host to the…”
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Trypanosoma brucei Orc1 is essential for nuclear DNA replication and affects both VSG silencing and VSG switching by Benmerzouga, Imaan, Concepción‐Acevedo, Jeniffer, Kim, Hee‐Sook, Vandoros, Anthula V., Cross, George A. M., Klingbeil, Michele M., Li, Bibo

“…Summary Binding of the Origin Recognition Complex (ORC) to replication origins is essential for initiation of DNA replication, but ORC has non‐essential…”
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Identification of Trypanosoma brucei RMI1/BLAP75 homologue and its roles in antigenic variation by Kim, Hee-Sook, Cross, George A M

“…At any time, each cell of the protozoan parasite Trypanosoma brucei expresses a single species of its major antigenic protein, the variant surface glycoprotein…”
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adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U deamination of DNA by Rubio, Mary Anne T, Pastar, Irena, Gaston, Kirk W, Ragone, Frank L, Janzen, Christian J, Cross, George A.M, Papavasiliou, F. Nina, Alfonzo, Juan D

“…Adenosine-to-inosine editing in the anticodon of tRNAs is essential for viability. Enzymes mediating tRNA adenosine deamination in bacteria and yeast contain…”
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Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes by Kawahara, Taemi, Siegel, T. Nicolai, Ingram, Alexandra K, Alsford, Sam, Cross, George A.M, Horn, David

“…Chromatin modification is important for virtually all aspects of DNA metabolism but little is known about the consequences of such modification in…”
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The in vivo dynamics of antigenic variation in Trypanosoma brucei by Mugnier, Monica R., Cross, George A. M., Papavasiliou, F. Nina

“…Trypanosoma brucei, a causative agent of African Sleeping Sickness, constantly changes its dense variant surface glycoprotein (VSG) coat to avoid elimination…”
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Telomere structure and function in trypanosomes: a proposal by Cross, George A. M, Dreesen, Oliver, Li, Bibo

“…Telomeres are specialized DNA-protein complexes that stabilize chromosome ends, protecting them from nucleolytic degradation and illegitimate recombination…”
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Telomerase-Independent Stabilization of Short Telomeres in Trypanosoma brucei by Dreesen, Oliver, Cross, George A. M.

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A variant histone H3 is enriched at telomeres in Trypanosoma brucei by Lowell, Joanna E, Cross, George A M

“…Variant histones play critical roles in transcriptional activation and repression, DNA repair and chromosome segregation. We have identified HTV, a single-copy…”
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Trypanosomal TBP Functions with the Multisubunit Transcription Factor tSNAP To Direct Spliced-Leader RNA Gene Expression by Das, Anish, Zhang, Qing, Palenchar, Jennifer B., Chatterjee, Bithi, Cross, George A. M., Bellofatto, Vivian

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Systematic Study of Sequence Motifs for RNA trans Splicing in Trypanosoma brucei by Siegel, T. Nicolai, Tan, Kevin S. W., Cross, George A. M.

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