Search Results - "Cross, Kevin P"

Visual Feedback Processing of the Limb Involves Two Distinct Phases by Cross, Kevin P, Cluff, Tyler, Takei, Tomohiko, Scott, Stephen H

“…Muscle responses to mechanical disturbances exhibit two distinct phases: a response starting at ~20 ms that is fairly stereotyped, and a response starting at…”
Get full text

Rotational dynamics in motor cortex are consistent with a feedback controller by Kalidindi, Hari Teja, Cross, Kevin P, Lillicrap, Timothy P, Omrani, Mohsen, Falotico, Egidio, Sabes, Philip N, Scott, Stephen H

“…Recent studies have identified rotational dynamics in motor cortex (MC), which many assume arise from intrinsic connections in MC. However, behavioral and…”
Get full text

Development of QSAR models to predict blood-brain barrier permeability by Faramarzi, Sadegh, Kim, Marlene T., Volpe, Donna A., Cross, Kevin P., Chakravarti, Suman, Stavitskaya, Lidiya

“…Assessing drug permeability across the blood-brain barrier (BBB) is important when evaluating the abuse potential of new pharmaceuticals as well as developing…”
Get full text

Independent representations of ipsilateral and contralateral limbs in primary motor cortex by Heming, Ethan A, Cross, Kevin P, Takei, Tomohiko, Cook, Douglas J, Scott, Stephen H

“…Several lines of research demonstrate that primary motor cortex (M1) is principally involved in controlling the contralateral side of the body. However, M1…”
Get full text

Improvement of quantitative structure–activity relationship (QSAR) tools for predicting Ames mutagenicity: outcomes of the Ames/QSAR International Challenge Project by Honma, Masamitsu, Kitazawa, Airi, Cayley, Alex, Williams, Richard V, Barber, Chris, Hanser, Thierry, Saiakhov, Roustem, Chakravarti, Suman, Myatt, Glenn J, Cross, Kevin P, Benfenati, Emilio, Raitano, Giuseppa, Mekenyan, Ovanes, Petkov, Petko, Bossa, Cecilia, Benigni, Romualdo, Battistelli, Chiara Laura, Giuliani, Alessandro, Tcheremenskaia, Olga, DeMeo, Christine, Norinder, Ulf, Koga, Hiromi, Jose, Ciloy, Jeliazkova, Nina, Kochev, Nikolay, Paskaleva, Vesselina, Yang, Chihae, Daga, Pankaj R, Clark, Robert D, Rathman, James

“…Abstract The International Conference on Harmonization (ICH) M7 guideline allows the use of in silico approaches for predicting Ames mutagenicity for the…”
Get full text

Characterization and validation of an in silico toxicology model to predict the mutagenic potential of drug impurities by Valerio, Luis G., Cross, Kevin P.

“…Control and minimization of human exposure to potential genotoxic impurities found in drug substances and products is an important part of preclinical safety…”
Get full text

Evaluating confidence in toxicity assessments based on experimental data and in silico predictions by Johnson, Candice, Anger, Lennart T., Benigni, Romualdo, Bower, David, Bringezu, Frank, Crofton, Kevin M., Cronin, Mark T.D., Cross, Kevin P., Dettwiler, Magdalena, Frericks, Markus, Melnikov, Fjodor, Miller, Scott, Roberts, David W., Suarez-Rodrigez, Diana, Roncaglioni, Alessandra, Lo Piparo, Elena, Tice, Raymond R., Zwickl, Craig, Myatt, Glenn J.

“…•Reliability, relevance, and confidence are key items in toxicological evaluations.•The terms are defined within the context of in silico analyses.•Practical…”
Get full text

Proprioceptive and Visual Feedback Responses in Macaques Exploit Goal Redundancy by Cross, Kevin P, Guang, Hui, Scott, Stephen H

“…A common problem in motor control concerns how to generate patterns of muscle activity when there are redundant solutions to attain a behavioral goal. Optimal…”
Get full text

Integration of proprioceptive and visual feedback during online control of reaching by Kasuga, Shoko, Crevecoeur, Frédéric, Cross, Kevin P, Balalaie, Parsa, Scott, Stephen H

“…Visual and proprioceptive feedback both contribute to perceptual decisions, but it remains unknown how these feedback signals are integrated together or…”
Get full text

Quantitative Structure–Activity Relationship Models to Predict Cardiac Adverse Effects by Mou, Zhongyu, Volarath, Patra, Racz, Rebecca, Cross, Kevin P., Girireddy, Mounika, Chakravarti, Suman, Stavitskaya, Lidiya

“…Drug-induced cardiotoxicity represents one of the most common causes of attrition of drug candidates in preclinical and clinical development. For this reason,…”
Get full text

Developing structure-activity relationships for N-nitrosamine activity by Cross, Kevin P., Ponting, David J.

“…[Display omitted] •N-Nitrosamine carcinogenic potency ranges from extreme to negligible or negative.•Specific structural features have clear effects on…”
Get full text

Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms by Wang, Yun-Jan, Dou, Jinhui, Cross, Kevin P., Valerio, Luis G.

“…Black cohosh, red clover, hops, and chasteberry are botanicals commonly used to alleviate menopausal symptoms in the US, and are examined in this study as part…”
Get full text

Maintained Representations of the Ipsilateral and Contralateral Limbs during Bimanual Control in Primary Motor Cortex by Cross, Kevin P, Heming, Ethan A, Cook, Douglas J, Scott, Stephen H

“…Primary motor cortex (M1) almost exclusively controls the contralateral side of the body. However, M1 activity is also modulated during ipsilateral body…”
Get full text

Analysis of chemical structures and mutations detected by Salmonella TA98 and TA100 by Cross, Kevin P, DeMarini, David M

“…As part of an analysis performed under the auspices of the International Workshop on Genotoxicity Testing (IWGT) in 2017, we and others showed that Salmonella…”
Get more information

Transitioning to composite bacterial mutagenicity models in ICH M7 (Q)SAR analyses by Landry, Curran, Kim, Marlene T., Kruhlak, Naomi L., Cross, Kevin P., Saiakhov, Roustem, Chakravarti, Suman, Stavitskaya, Lidiya

“…The International Council on Harmonisation (ICH) M7(R1) guideline describes the use of complementary (quantitative) structure-activity relationship ((Q)SAR)…”
Get full text

Are all bacterial strains required by OECD mutagenicity test guideline TG471 needed? by Williams, Richard V., DeMarini, David M., Stankowski, Leon F., Escobar, Patricia A., Zeiger, Errol, Howe, Jonathan, Elespuru, Rosalie, Cross, Kevin P.

“…•Salmonella TA1535 detected few mutagens not detected by Salmonella TA100.•Salmonella TA97 should be used in preference to Salmonella TA1537.•Escherichia coli…”
Get full text

Development of improved QSAR models for predicting the outcome of the in vivo micronucleus genetic toxicity assay by Yoo, Jae Wook, Kruhlak, Naomi L., Landry, Curran, Cross, Kevin P., Sedykh, Alexander, Stavitskaya, Lidiya

“…All drugs entering clinical trials are expected to undergo a series of in vitro and in vivo genotoxicity tests as outlined in the International Council on…”
Get full text

Correlations Between Primary Motor Cortex Activity with Recent Past and Future Limb Motion During Unperturbed Reaching by Takei, Tomohiko, Crevecoeur, Frédéric, Herter, Troy M, Cross, Kevin P, Scott, Stephen H

“…Many studies highlight that human movements are highly successful yet display a surprising amount of variability from trial to trial. There is a consistent…”
Get full text

Genetic toxicology in silico protocol by Hasselgren, Catrin, Ahlberg, Ernst, Akahori, Yumi, Amberg, Alexander, Anger, Lennart T, Atienzar, Franck, Auerbach, Scott, Beilke, Lisa, Bellion, Phillip, Benigni, Romualdo, Bercu, Joel, Booth, Ewan D, Bower, Dave, Brigo, Alessandro, Cammerer, Zoryana, Cronin, Mark T D, Crooks, Ian, Cross, Kevin P, Custer, Laura, Dobo, Krista, Doktorova, Tatyana, Faulkner, David, Ford, Kevin A, Fortin, Marie C, Frericks, Markus, Gad-McDonald, Samantha E, Gellatly, Nichola, Gerets, Helga, Gervais, Véronique, Glowienke, Susanne, Van Gompel, Jacky, Harvey, James S, Hillegass, Jedd, Honma, Masamitsu, Hsieh, Jui-Hua, Hsu, Chia-Wen, Barton-Maclaren, Tara S, Johnson, Candice, Jolly, Robert, Jones, David, Kemper, Ray, Kenyon, Michelle O, Kruhlak, Naomi L, Kulkarni, Sunil A, Kümmerer, Klaus, Leavitt, Penny, Masten, Scott, Miller, Scott, Moudgal, Chandrika, Muster, Wolfgang, Paulino, Alexandre, Lo Piparo, Elena, Powley, Mark, Quigley, Donald P, Reddy, M Vijayaray, Richarz, Andrea-Nicole, Schilter, Benoit, Snyder, Ronald D, Stavitskaya, Lidiya, Stidl, Reinhard, Szabo, David T, Teasdale, Andrew, Tice, Raymond R, Trejo-Martin, Alejandra, Vuorinen, Anna, Wall, Brian A, Watts, Pete, White, Angela T, Wichard, Joerg, Witt, Kristine L, Woolley, Adam, Woolley, David, Zwickl, Craig, Myatt, Glenn J

“…In silico toxicology (IST) approaches to rapidly assess chemical hazard, and usage of such methods is increasing in all applications but especially for…”
Get full text

Rapid Online Corrections for Proprioceptive and Visual Perturbations Recruit Similar Circuits in Primary Motor Cortex by Cross, Kevin P, Cook, Douglas J, Scott, Stephen H

“…An important aspect of motor function is our ability to rapidly generate goal-directed corrections for disturbances to the limb or behavioral goal. The primary…”
Get full text