Incidence rates of leukemias, lymphomas and myelomas in Italy: Geographic distribution and NHL histotypes

The annual incidence of non‐Hodgkin's lymphomas is increasing by 3 to 4% in different parts of the developed world, while rates for Hodgkin's disease, myelomas and leukemias are more stable. In the case of this group of malignancies, hypothesis generation on risk factors has been limited b...

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Bibliographic Details
Published in:	International journal of cancer Vol. 68; no. 2; pp. 156 - 159
Main Authors:	Masala, Giovanna, Di Lollo, Simonetta, Picoco, Cosimo, Crosignant, Paolo, Demicheli, Vittorio, Fontana, Arabella, Funtó, Ilaria, Miligi, Lucia, Nanni, Oriana, Papucci, Alessandra, Ramazzotti, Valerio, Rodella, Stefania, Stagnaro, Emanuele, Tumino, Rosario, Viganó, Clotilde, Vindigni, Carla, Seniori Costantini, Adele, Vineis, Paolo
Format:	Journal Article
Language:	English
Published:	New York Wiley Subscription Services, Inc., A Wiley Company 09-10-1996 Wiley-Liss
Subjects:	Adult Aged Biological and medical sciences Case-Control Studies Female Hematologic and hematopoietic diseases Hodgkin Disease - epidemiology Humans Incidence Italy - epidemiology Leukemia - epidemiology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Non-Hodgkin - epidemiology Male Medical sciences Middle Aged Multiple Myeloma - epidemiology Rural Health Sex Distribution Urban Health Italy Europe Human Immunopathology Leukemia Malignant hemopathy Myeloma Epidemiology Lymphoma Incidence Immunoglobulinopathy Geographic distribution Lymphoproliferative syndrome Histological type Public health
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Summary:	The annual incidence of non‐Hodgkin's lymphomas is increasing by 3 to 4% in different parts of the developed world, while rates for Hodgkin's disease, myelomas and leukemias are more stable. In the case of this group of malignancies, hypothesis generation on risk factors has been limited by the use of the ICD classification in mortality and incidence statistics. We have computed incidence rates in different Italian areas after careful re‐classification of diagnoses, and considering specific histotypes (Working Formulation for NHL, Rye's classification for HD). While no particularly interesting pattern is suggested for Hodgkin's disease (even after considering specific Rye sub‐groups), multiple myeloma and leukemias, for non‐Hodgkin's lymphomas the high rate in one agricultural area (Forli) was mainly due to the A sub‐group in the Working Formulation (low‐grade). In a heavily industrialized area (Varese), the high incidence rate was at least partly explained by a higher proportion of cases classified in the G sub‐group (intermediate grade). Excesses of non‐Hodgkin's lymphomas have been observed in populations exposed to phenoxy‐acetic‐acid herbicides, to insecticides and to organic solvents. One can hypothesize that different risk factors act on different stem cells and induce lymphoid malignancies belonging to different histologic sub‐types. © 1996 Wiley‐Liss, Inc.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0020-7136 1097-0215
DOI:	10.1002/(SICI)1097-0215(19961009)68:2<156::AID-IJC2>3.0.CO;2-X