Search Results - "Crosetto, N."

Cisplatin-based chemoradiation plus cetuximab in locally advanced head and neck cancer: a phase II clinical study by Merlano, M., Russi, E., Benasso, M., Corvò, R., Colantonio, I., Vigna-Taglianti, R., Vigo, V., Bacigalupo, A., Numico, G., Crosetto, N., Gasco, M., Lo Nigro, C., Vitiello, R., Violante, S., Garrone, O.

“…Intensification of chemoradiation for advanced head and neck squamous cell carcinoma (HNSCC) is unlikely due to toxicity. Cetuximab combined either with…”
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Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression by Pareja, F, Ferraro, D A, Rubin, C, Cohen-Dvashi, H, Zhang, F, Aulmann, S, Ben-Chetrit, N, Pines, G, Navon, R, Crosetto, N, Köstler, W, Carvalho, S, Lavi, S, Schmitt, F, Dikic, I, Yakhini, Z, Sinn, P, Mills, G B, Yarden, Y

“…Once stimulated, the epidermal growth factor receptor (EGFR) undergoes self-phosphorylation, which, on the one hand, instigates signaling cascades, and on the…”
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Inter- and intratumoral heterogeneity of BCL2 correlates with IgH expression and prognosis in follicular lymphoma by Barreca, A, Martinengo, C, Annaratone, L, Righi, L, Chiappella, A, Ladetto, M, Demurtas, A, Chiusa, L, Stacchini, A, Crosetto, N, van Oudenaarden, A, Chiarle, R

“…Most follicular lymphomas (FLs) are genetically defined by the t(14;18)(q32;q21) translocation that juxtaposes the BCL2 gene to the immunoglobulin heavy chain…”
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Is FISH a relevant prognostic tool in myelodysplastic syndromes with a normal chromosome pattern on conventional cytogenetics? A study on 57 patients by BERNASCONI, P, CAVIGLIANO, P. M, BERNASCONI, C, BONI, M, CALATRONI, S, KLERSY, C, GIARDINI, I, ROCCA, B, CROSETTO, N, CARESANA, M, LAZZARINO, M

“…Conventional cytogenetics (CC) at clinical diagnosis shows a normal karyotype in 40-60% of de novo myelodysplastic syndromes (MDSs). Fluorescence in situ…”
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Spatially resolved transcriptomics and beyond by Crosetto, Nicola, Bienko, Magda, van Oudenaarden, Alexander

“…Preserving spatial information in gene expression analyses is key for interpreting the single-cell tissue context (and even subcellular environments) of RNAs…”
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Pavia symposium on embryos and stem cells by Boiani, M, Crosetto, N, Redi, C A

“…Stem cells occur in very small numbers in adult tissues, in higher numbers in the fetus and its annexes and they can be derived from whole embryos or parts…”
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Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing by Kim, Charissa, Gao, Ruli, Sei, Emi, Brandt, Rachel, Hartman, Johan, Hatschek, Thomas, Crosetto, Nicola, Foukakis, Theodoros, Navin, Nicholas E.

“…Triple-negative breast cancer (TNBC) is an aggressive subtype that frequently develops resistance to chemotherapy. An unresolved question is whether resistance…”
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Discovering CRISPR–Cas off-target breaks by Jiménez, Carlos, Crosetto, Nicola

“…DISCOVER-seq+ enables the efficient detection of CRISPR–Cas off-target breaks in primary cells and tissues…”
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The era of 3D and spatial genomics by Bouwman, Britta A.M., Crosetto, Nicola, Bienko, Magda

“…Over a decade ago the advent of high-throughput chromosome conformation capture (Hi-C) sparked a new era of 3D genomics. Since then the number of methods for…”
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Engineered Cpf1 variants with altered PAM specificities by Gao, Linyi, Cox, David B T, Yan, Winston X, Manteiga, John C, Schneider, Martin W, Yamano, Takashi, Nishimasu, Hiroshi, Nureki, Osamu, Crosetto, Nicola, Zhang, Feng

“…The targeting range of the CRISPR endonuclease Cpf1 is increased three-fold by molecular engineering. The RNA-guided endonuclease Cpf1 is a promising tool for…”
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A GC-centered view of 3D genome organization by Bouwman, Britta AM, Crosetto, Nicola, Bienko, Magda

“…In the past two decades, our understanding of how the genome of mammalian cells is spatially organized in the three-dimensional (3D) space of the nucleus and…”
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BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks by Yan, Winston X., Mirzazadeh, Reza, Garnerone, Silvano, Scott, David, Schneider, Martin W., Kallas, Tomasz, Custodio, Joaquin, Wernersson, Erik, Li, Yinqing, Gao, Linyi, Federova, Yana, Zetsche, Bernd, Zhang, Feng, Bienko, Magda, Crosetto, Nicola

“…Precisely measuring the location and frequency of DNA double-strand breaks (DSBs) along the genome is instrumental to understanding genomic fragility, but…”
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Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing by Crosetto, Nicola, Mitra, Abhishek, Silva, Maria Joao, Bienko, Magda, Dojer, Norbert, Wang, Qi, Karaca, Elif, Chiarle, Roberto, Skrzypczak, Magdalena, Ginalski, Krzysztof, Pasero, Philippe, Rowicka, Maga, Dikic, Ivan

“…Biotinylated tags bind double-strand breaks in genomic DNA; after enrichment and sequencing, this allows precise, genome-wide mapping of the breaks. We present…”
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Colibactin DNA-damage signature indicates mutational impact in colorectal cancer by Dziubańska-Kusibab, Paulina J., Berger, Hilmar, Battistini, Federica, Bouwman, Britta A. M., Iftekhar, Amina, Katainen, Riku, Cajuso, Tatiana, Crosetto, Nicola, Orozco, Modesto, Aaltonen, Lauri A., Meyer, Thomas F.

“…The mucosal epithelium is a common target of damage by chronic bacterial infections and the accompanying toxins, and most cancers originate from this tissue…”
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RNA gradients: Shapers of 3D genome architecture by Bouwman, Britta A.M., Crosetto, Nicola, Bienko, Magda

“…A growing body of evidence points to a role of nuclear RNAs (nucRNAs) in shaping the three-dimensional (3D) architecture of the genome within the nucleus of a…”
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Single-cell 5hmC sequencing reveals chromosome-wide cell-to-cell variability and enables lineage reconstruction by Mooijman, Dylan, Dey, Siddharth S, Boisset, Jean-Charles, Crosetto, Nicola, van Oudenaarden, Alexander

“…A genome-wide, strand-specific sequencing method to detect 5-hydroxymethylcytosine marks in single cells is developed. The epigenetic DNA modification…”
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Radial Organization in the Mammalian Nucleus by Crosetto, Nicola, Bienko, Magda

“…In eukaryotic cells, most of the genetic material is contained within a highly specialized organelle-the nucleus. A large body of evidence indicates that,…”
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Emerging methods and applications in 3D genomics by Pedrotti, Simona, Castiglioni, Ilaria, Perez-Estrada, Cynthia, Zhao, Linxuan, Chen, Jinxin Phaedo, Crosetto, Nicola, Bienko, Magda

“…Since the advent of Hi-C in 2009, a plethora of high-throughput sequencing methods have emerged to profile the three-dimensional (3D) organization of…”
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Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations by Gothe, Henrike Johanna, Bouwman, Britta Annika Maria, Gusmao, Eduardo Gade, Piccinno, Rossana, Petrosino, Giuseppe, Sayols, Sergi, Drechsel, Oliver, Minneker, Vera, Josipovic, Natasa, Mizi, Athanasia, Nielsen, Christian Friberg, Wagner, Eva-Maria, Takeda, Shunichi, Sasanuma, Hiroyuki, Hudson, Damien Francis, Kindler, Thomas, Baranello, Laura, Papantonis, Argyris, Crosetto, Nicola, Roukos, Vassilis

“…How spatial chromosome organization influences genome integrity is still poorly understood. Here, we show that DNA double-strand breaks (DSBs) mediated by…”
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Nanogrid single-nucleus RNA sequencing reveals phenotypic diversity in breast cancer by Gao, Ruli, Kim, Charissa, Sei, Emi, Foukakis, Theodoros, Crosetto, Nicola, Chan, Leong-Keat, Srinivasan, Maithreyan, Zhang, Hong, Meric-Bernstam, Funda, Navin, Nicholas

“…Single cell RNA sequencing has emerged as a powerful tool for resolving transcriptional diversity in tumors, but is limited by throughput, cost and the ability…”
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