Isolated del(14)(q21) in a case of precursor B-cell acute lymphoblastic leukemia

We present a case of del(14)(q21) as a sole abnormality in a 4-year-old boy diagnosed with precursor B-cell acute lymphoblastic leukemia (pre-B ALL). To our knowledge, this is the first case of isolated del(14)(q21) in pre-B ALL. Two pretreatment bone marrow samples obtained 5 days apart were analyz...

Full description

Saved in:

Bibliographic Details
Published in:	Cancer genetics and cytogenetics Vol. 161; no. 1; pp. 82 - 85
Main Authors:	Meloni-Ehrig, Aurelia M., Tirado, Carlos A., Chen, Kuoping, Jahn, Jennifer, Suchan, Stephany, Scheerle, Jay, Crosby, Maria Gabriela, Meany, Holly, Seibel, Nita, Leitenberg, David, Heritage, Deborah W., Mowrey, Philip N.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-08-2005
Subjects:	Child, Preschool Chromosomes, Human, Pair 4 - genetics Core Binding Factor Alpha 2 Subunit Gene Deletion Gene Rearrangement Humans Immunoglobulin Heavy Chains In Situ Hybridization, Fluorescence Interphase Karyotyping Male Oncogene Proteins, Fusion - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	We present a case of del(14)(q21) as a sole abnormality in a 4-year-old boy diagnosed with precursor B-cell acute lymphoblastic leukemia (pre-B ALL). To our knowledge, this is the first case of isolated del(14)(q21) in pre-B ALL. Two pretreatment bone marrow samples obtained 5 days apart were analyzed by cytogenetics. The G-banded karyotypes of the two samples were similar, differing only in the ratio of normal/abnormal metaphases detected. Both samples showed a del(14)(q21) as the only abnormality. Fluorescence in situ hybridization performed using the probes TEL/AML1 and immunoglobulin heavy chain (IGH) showed no fusion involving the TEL and AML1 genes and only a single IGH signal in 20% of the interphase cells analyzed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0165-4608 1873-4456
DOI:	10.1016/j.cancergencyto.2004.12.022