Search Results - "Crosby, Heather A."

Adhesion of human haematopoietic (CD34+ ) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4 by Crosby, Heather A, Lalor, Patricia F, Ross, Emma, Newsome, Philip N, Adams, David H

“…Background/Aims Haematopoietic stem cells (HSC) have previously been shown in some studies to migrate to damaged and diseased liver where a small proportion…”
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The role of Notch receptor expression in bile duct development and disease by Flynn, Diana M, Nijjar, Sarbjit, Hubscher, Stefan G, de Goyet, Jean de Ville, Kelly, Deirdre A, Strain, Alastair J, Crosby, Heather A

“…Mutations in the Jagged1 gene, a ligand for the Notch signalling pathway, have been implicated in the pathogenesis of Alagille syndrome (AGS), resulting in…”
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Characterization and Isolation of Ductular Cells Coexpressing Neural Cell Adhesion Molecule and Bcl-2 from Primary Cholangiopathies and Ductal Plate Malformations by Fabris, Luca, Strazzabosco, Mario, Crosby, Heather A., Ballardini, Giorgio, Hubscher, Stefan G., Kelly, Deirdre A., Neuberger, James M., Strain, Alastair J., Joplin, Ruth

“…It has recently been shown that reactive bile ductules display neuroendocrine features, including immunoreactivity for the neural cell adhesion molecule…”
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Progenitor cells of the biliary epithelial cell lineage by Crosby, Heather A, Nijjar, Sarbjit S, de Goyet, Jean de Ville, Kelly, Deirdre A, Strain, Alastair J

“…Stem-like cells have been identified in liver that are able to differentiate in vivo and in culture to biliary epithelial cells (BEC), hepatocytes and oval…”
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A Novel Cell‐Surface Marker Found on Human Embryonic Hepatoblasts and a Subpopulation of Hepatic Biliary Epithelial Cells by Stamp, Lincon, Crosby, Heather A., Hawes, Susan M., Strain, Alastair J., Pera, Martin F.

“…The nature of the cells that contribute to the repopulation of the liver after hepatic necrosis or cirrhosis remains uncertain, in part because we lack…”
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Human hepatic stem-like cells isolated using c-kit or CD34 can differentiate into biliary epithelium by Crosby, Heather A., Kelly, Deirdre A., Strain, Alastair J.

“…Background & Aims: Recent reports suggest that after bone marrow transplantation into rodents and humans, hematopoietic stem cells migrate into the liver and…”
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Expression of the stem cell factor receptor c‐kit in normal and diseased pediatric liver: Identification of a human hepatic progenitor cell? by Baumann, Ulrich, Crosby, Heather A., Ramani, Pramila, Kelly, Deirdre A., Strain, Alastair J.

“…The stem cell factor (SCF)/c‐kit ligand/receptor system has been implicated in stem (oval) cell activation following liver injury in the rat. The aim of this…”
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Altered Notch Ligand Expression in Human Liver Disease : Further Evidence for a Role of the Notch Signaling Pathway in Hepatic Neovascularization and Biliary Ductular Defects by Nijjar, Sarbjit S, Wallace, Lorraine, Crosby, Heather A, Hubscher, Stefan G, Strain, Alastair J

“…The Jagged and Delta family of transmembrane proteins are ligands for Notch receptors, which control the proliferation and/or differentiation of many cell…”
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Notch receptor expression in adult human liver: A possible role in bile duct formation and hepatic neovascularization by Nijjar, Sarbjit S., Crosby, Heather A., Wallace, Lorraine, Hubscher, Stefan G., Strain, Alastair J.

“…Notch signaling is an evolutionarily conserved mechanism, used to regulate cell fate decisions. Four Notch receptors have been identified in man (Notch-1 to…”
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Immunolocalization of putative human liver progenitor cells in livers from patients with end-stage primary biliary cirrhosis and sclerosing cholangitis using the monoclonal antibody OV-6 by Crosby, HA, Hubscher, S, Fabris, L, Joplin, R, Sell, S, Kelly, D, Strain, AJ

“…The term oval cell describes small cells with oval nuclei that arise in the periphery of the portal tracts in rat models of hepatocarcinogenesis and injury and…”
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Human liver-derived stem cells by Strain, Alastair J, Crosby, Heather A, Nijjar, Sarbjit, Kelly, Deirdre A, Hubscher, Stefan G

“…The search for human oval cells or bi-potential stem cells in the human liver is the subject of intensive investigation. Fetal hepatocytes (hepatoblasts) have…”
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Immunolocalization of OV‐6, a putative progenitor cell marker in human fetal and diseased pediatric liver by Crosby, Heather A., Hubscher, Stefan G., Joplin, Ruth E., Kelly, Deirdre A., Strain, Alastair J.

“…The existence of progenitor (stem) cells in the human liver remains a matter of debate. In rodent models of hepatocarcinogenesis and injury, oval cells…”
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Altered Notch Ligand Expression in Human Liver Disease by Nijjar, Sarbjit S., Wallace, Lorraine, Crosby, Heather A., Hubscher, Stefan G., Strain, Alastair J.

“…The Jagged and Delta family of transmembrane proteins are ligands for Notch receptors, which control the proliferation and/or differentiation of many cell…”
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Nomenclature of the finer branches of the biliary tree: Canals, ductules, and ductular reactions in human livers by Roskams, Tania A., Theise, Neil D., Balabaud, Charles, Bhagat, Govind, Bhathal, Prithi S., Bioulac‐Sage, Paulette, Brunt, Elizabeth M., Crawford, James M., Crosby, Heather A., Desmet, Valeer, Finegold, Milton J., Geller, Stephen A., Gouw, Annette S.H., Hytiroglou, Prodromos, Knisely, A.S., Kojiro, Masamichi, Lefkowitch, Jay H., Nakanuma, Yasuni, Olynyk, John K., Nyun Park, Young, Portmann, Bernard, Saxena, Romil, Scheuer, Peter J., Strain, Alastair J., Thung, Swan N., Wanless, Ian R., West, A. Brian

“…The work of liver stem cell biologists, largely carried out in rodent models, has now started to manifest in human investigations and applications. We can now…”
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CD40 activation‐induced, Fas‐dependent apoptosis and NF‐κB/AP‐1 signaling in human intrahepatic biliary epithelial cells by AFFORD, SIMON C., AHMED-CHOUDHURY, JALAL, RANDHAWA, SATINDER, RUSSELL, CLARE, YOUSTER, JANINE, CROSBY, HEATHER A., ELIOPOULOS, ARISTIDES, HUBSCHER, STEFAN G., YOUNG, LAWRENCE S., ADAMS, DAVID H.

“…ABSTRACT Fas‐mediated mechanisms of apoptosis are thought to be involved in the bile duct loss that characterizes diseases such as primary biliary cirrhosis…”
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Further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defects by NIJJAR, Sarbjit S, WALLACE, Lorraine, CROSBY, Heather A, HUBSCHER, Stefan G, STRAIN, Alastair J

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Selective decontamination of the digestive tract reduces gram-negative pulmonary colonization but not systemic endotoxemia in patients undergoing elective liver transplantation by Bion, J F, Badger, I, Crosby, H A, Hutchings, P, Kong, K L, Baker, J, Hutton, P, McMaster, P, Buckels, J A, Elliott, T S

“…To examine the effect of selective antibiotic decontamination of the digestive tract in patients undergoing elective orthotopic liver transplantation…”
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Correction by Fabris, Luca, Strazzabosco, Mario, Crosby, Heather A., Ballardini, Giorgio, Hubscher, Stefan G., Kelly, Deirdre A., Neuberger, James M., Strain, Alastair J., Joplin, Ruth

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Antibiotic-induced release of endotoxin from bacteria in vitro by Crosby, Heather A, Bion, J. F, Penn, C. W, Elliott, T. S. J

“…* Departments of Clinical Microbiology Intensive Care, Queen Elizabeth Hospital, Birmingham B15 2TH School of Biological Sciences, University of Birmingham,…”
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