Search Results - "Crosby, Erika J"

Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection by Crosby, Erika J, Goldschmidt, Michael H, Wherry, E John, Scott, Phillip

“…One of the hallmarks of adaptive immunity is the development of a long-term pathogen specific memory response. While persistent memory T cells certainly impact…”
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Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors by Crosby, Erika J., Wei, Junping, Yang, Xiao Yi, Lei, Gangjun, Wang, Tao, Liu, Cong-Xiao, Agarwal, Pankaj, Korman, Alan J., Morse, Michael A., Gouin, Kenneth, Knott, Simon R. V., Lyerly, H. Kim, Hartman, Zachary C.

“…Triple-negative breast cancer (TNBC) is an aggressive and molecularly diverse breast cancer subtype typified by the presence of p53 mutations (∼80%), elevated…”
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Combination of ultrasound-based mechanical disruption of tumor with immune checkpoint blockade modifies tumor microenvironment and augments systemic antitumor immunity by Abe, Shinya, Nagata, Hiroshi, Crosby, Erika J, Inoue, Yoshiyuki, Kaneko, Kensuke, Liu, Cong-Xiao, Yang, Xiao, Wang, Tao, Acharya, Chaitanya R, Agarwal, Pankaj, Snyder, Joshua, Gwin, William, Morse, Michael A, Zhong, Pei, Lyerly, Herbert Kim, Osada, Takuya

“…BackgroundDespite multimodal adjuvant management with radiotherapy, chemotherapy and hormonal therapies, most surgically resected primary breast cancers…”
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Vaccines targeting ESR1 activating mutations elicit anti-tumor immune responses and suppress estrogen signaling in therapy resistant ER+ breast cancer by Dailey, Gabrielle P, Rabiola, Christopher A, Lei, Gangjun, Wei, Junping, Yang, Xiao-Yi, Wang, Tao, Liu, Cong-Xiao, Gajda, Melissa, Hobeika, Amy C, Summers, Amanda, Marek, Robert D, Morse, Michael A, Lyerly, Herbert K, Crosby, Erika J, Hartman, Zachary C

“…ER+ breast cancers (BC) are characterized by the elevated expression and signaling of estrogen receptor alpha ( , which renders them sensitive to…”
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Long-term survival of patients with stage III colon cancer treated with VRP-CEA(6D), an alphavirus vector that increases the CD8+ effector memory T cell to Treg ratio by Crosby, Erika J, Hobeika, Amy C, Niedzwiecki, Donna, Rushing, Christel, Hsu, David, Berglund, Peter, Smith, Jonathan, Osada, Takuya, Gwin III, William R, Hartman, Zachary C, Morse, Michael A, Lyerly, Herbert Kim

“…BackgroundThere remains a significant need to eliminate the risk of recurrence of resected cancers. Cancer vaccines are well tolerated and activate…”
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Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis by Tsao, Li-Chung, Crosby, Erika J, Trotter, Timothy N, Wei, Junping, Wang, Tao, Yang, Xiao, Summers, Amanda N, Lei, Gangjun, Rabiola, Christopher A, Chodosh, Lewis A, Muller, William J, Lyerly, Herbert Kim, Hartman, Zachary C

“…Two HER2-specific mAbs, trastuzumab and pertuzumab (T+P), combined with chemotherapy comprise standard-of-care treatment for advanced HER2+ breast cancers…”
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Beyond Neoantigens: Antigens Derived from Tumor Drivers as Cancer Vaccine Targets by Crosby, Erika J, Hartman, Zachary C, Lyerly, H Kim

“…A vaccine targeting HER2, a nonmutated but overexpressed tumor antigen, readily primed T cells for ex vivo expansion and adoptive transfer with minimal…”
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Cancer vaccine strategies using self-replicating RNA viral platforms by Dailey, Gabrielle P., Crosby, Erika J., Hartman, Zachary C.

“…The development and success of RNA-based vaccines targeting SARS-CoV-2 has awakened new interest in utilizing RNA vaccines against cancer, particularly in the…”
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Clinical trials of self-replicating RNA-based cancer vaccines by Morse, Michael A., Crosby, Erika J., Force, Jeremy, Osada, Takuya, Hobeika, Amy C., Hartman, Zachary C., Berglund, Peter, Smith, Jonathan, Lyerly, H. Kim

“…Therapeutic cancer vaccines, designed to activate immune effectors against tumor antigens, utilize a number of different platforms for antigen delivery. Among…”
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Vaccine-Induced Memory CD8 + T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study by Crosby, Erika J, Gwin, William, Blackwell, Kimberly, Marcom, Paul K, Chang, Serena, Maecker, Holden T, Broadwater, Gloria, Hyslop, Terry, Kim, Sungjin, Rogatko, Andre, Lubkov, Veronica, Snyder, Joshua C, Osada, Takuya, Hobeika, Amy C, Morse, Michael A, Lyerly, H Kim, Hartman, Zachary C

“…Immune-based therapy for metastatic breast cancer has had limited success, particularly in molecular subtypes with low somatic mutations rates. Strategies to…”
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Intratumoral Plasmid IL12 Expands CD8 + T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti-PD-1 Therapy by Telli, Melinda L, Nagata, Hiroshi, Wapnir, Irene, Acharya, Chaitanya R, Zablotsky, Kaitlin, Fox, Bernard A, Bifulco, Carlo B, Jensen, Shawn M, Ballesteros-Merino, Carmen, Le, Mai Hope, Pierce, Robert H, Browning, Erica, Hermiz, Reneta, Svenson, Lauren, Bannavong, Donna, Jaffe, Kim, Sell, Jendy, Foerter, Kellie Malloy, Canton, David A, Twitty, Christopher G, Osada, Takuya, Lyerly, H Kim, Crosby, Erika J

“…Triple-negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options. Antibodies targeting programmed cell death protein 1…”
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Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major by Crosby, Erika J, Clark, Megan, Novais, Fernanda O, Wherry, E John, Scott, Phillip

“…Leishmaniasis is a significant neglected tropical disease that is associated with a wide range of clinical presentations and a lifelong persistent infection…”
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Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer by Crosby, Erika J, Acharya, Chaitanya R, Haddad, Anthony-Fayez, Rabiola, Christopher A, Lei, Gangjun, Wei, Jun-Ping, Yang, Xiao-Yi, Wang, Tao, Liu, Cong-Xiao, Wagner, Kay U, Muller, William J, Chodosh, Lewis A, Broadwater, Gloria, Hyslop, Terry, Shepherd, Jonathan H, Hollern, Daniel P, He, Xiaping, Perou, Charles M, Chai, Shengjie, Ashby, Benjamin K, Vincent, Benjamin G, Snyder, Joshua C, Force, Jeremy, Morse, Michael A, Lyerly, Herbert K, Hartman, Zachary C

“…Despite promising advances in breast cancer immunotherapy, augmenting T-cell infiltration has remained a significant challenge. Although neither individual…”
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Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation by Gómez, Daniela, Diehl, Malissa C, Crosby, Erika J, Weinkopff, Tiffany, Debes, Gudrun F

“…Memory/effector T cells recirculate through extralymphoid tissues by entering from blood and egressing via afferent lymph. Although T cell entry into effector…”
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CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis by Tsao, Li-Chung, Crosby, Erika J, Trotter, Timothy N, Agarwal, Pankaj, Hwang, Bin-Jin, Acharya, Chaitanya, Shuptrine, Casey W, Wang, Tao, Wei, Junping, Yang, Xiao, Lei, Gangjun, Liu, Cong-Xiao, Rabiola, Christopher A, Chodosh, Lewis A, Muller, William J, Lyerly, Herbert Kim, Hartman, Zachary C

“…The HER2-specific monoclonal antibody (mAb), trastuzumab, has been the mainstay of therapy for HER2+ breast cancer (BC) for approximately 20 years. However,…”
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Cancer vaccines: the importance of targeting oncogenic drivers and the utility of combinations with immune checkpoint inhibitors by Crosby, Erika J, Lyerly, H Kim, Hartman, Zachary C

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HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study by Osada, Takuya, Crosby, Erika J, Kaneko, Kensuke, Snyder, Joshua C, Ginzel, Joshua D, Acharya, Chaitanya R, Yang, Xiao-Yi, Polascik, Thomas J, Spasojevic, Ivan, Nelson, Rendon C, Hobeika, Amy, Hartman, Zachary C, Neckers, Leonard M, Rogatko, Andre, Hughes, Philip F, Huang, Jiaoti, Morse, Michael A, Haystead, Timothy, Lyerly, H Kim

“…A noninvasive test to discriminate indolent prostate cancers from lethal ones would focus treatment where necessary while reducing overtreatment. We exploited…”
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HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase by Ginzel, Joshua D, Acharya, Chaitanya R, Lubkov, Veronica, Mori, Hidetoshi, Boone, Peter G, Rochelle, Lauren K, Roberts, Wendy L, Everitt, Jeffrey I, Hartman, Zachary C, Crosby, Erika J, Barak, Lawrence S, Caron, Marc G, Chen, Jane Q, Hubbard, Neil E, Cardiff, Robert D, Borowsky, Alexander D, Lyerly, H Kim, Snyder, Joshua C

“…HER2-positive breast cancers are among the most heterogeneous breast cancer subtypes. The early amplification of HER2 and its known oncogenic isoforms provide…”
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Key takeaways for knowledge expansion of early-career scientists conducting Transdisciplinary Research in Energetics and Cancer (TREC): a report from the TREC Training Workshop 2022 by Kung, Che-Pei, Skiba, Meghan B, Crosby, Erika J, Gorzelitz, Jessica, Kennedy, Mary A, Kerr, Bethany A, Li, Yun Rose, Nash, Sarah, Potiaumpai, Melanie, Kleckner, Amber S, James, Dara L, Coleman, Michael F, Fairman, Ciaran M, Galván, Gloria C, Garcia, David O, Gordon, Max J, His, Mathilde, Hornbuckle, Lyndsey M, Kim, So-Youn, Kim, Tae-Hyung, Kumar, Amanika, Mahé, Mélanie, McDonnell, Karen K, Moore, Jade, Oh, Sangphil, Sun, Xinghui, Irwin, Melinda L

“…The overall goal of the annual Transdisciplinary Research in Energetics and Cancer (TREC) Training Workshop is to provide transdisciplinary training for…”
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876 Self-replicating RNA therapeutics for off-the-shelf precision immunotherapy targeting acquired resistance mutations in low TMB tumors by Goldberg, Zelanna, Maine, Christian, Dailey, Gabrielle P, Domingo, Christine, Picarda, Gaelle, Little, Hunter, Chou, Annie, Sparks, Jessica, Spasova, Darina, Miyake-Stoner, Shigeki, Rabiola, Christopher A, Crosby, Erika J, Hartman, Zachary C, Lyerly, Herbert K, Wang, Nathaniel, Aliahmad, Parinaz

“…BackgroundKeynote-942 (AACR 2023; ASCO 2023) represents the first clinical success of a personalized cancer vaccine. mRNA-4157 is a personalized neoantigen…”
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