Search Results - "Crosby, David C."

CBFβ Stabilizes HIV Vif to Counteract APOBEC3 at the Expense of RUNX1 Target Gene Expression by Kim, Dong Young, Kwon, Eunju, Hartley, Paul D., Crosby, David C., Mann, Sumanjit, Krogan, Nevan J., Gross, John D.

“…The HIV-1 accessory protein Vif hijacks a cellular Cullin-RING ubiquitin ligase, CRL5, to promote degradation of the APOBEC3 (A3) family of restriction…”
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RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev-Rev response element complex by Jayaraman, Bhargavi, Crosby, David C, Homer, Christina, Ribeiro, Isabel, Mavor, David, Frankel, Alan D

“…The HIV-1 protein Rev controls a critical step in viral replication by mediating the nuclear export of unspliced and singly-spliced viral mRNAs. Multiple Rev…”
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Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G by Stanley, David J, Bartholomeeusen, Koen, Crosby, David C, Kim, Dong Young, Kwon, Eunju, Yen, Linda, Cartozo, Nathalie Caretta, Li, Ming, Jäger, Stefanie, Mason-Herr, Jeremy, Hayashi, Fumiaki, Yokoyama, Shigeyuki, Krogan, Nevan J, Harris, Reuben S, Peterlin, Boris Matija, Gross, John D

“…Cellular restriction factors help to defend humans against human immunodeficiency virus (HIV). HIV accessory proteins hijack at least three different…”
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Antibacterial Activity of Four Human Beta-Defensins: HBD-19, HBD-23, HBD-27, and HBD-29 by Chow, Bryan T., Soto, Maira, Lo, Bonnie L., Crosby, David C., Camerini, David

“…Human β-defensins (HBD) are a family of small antimicrobial peptides that play important roles in the innate and adaptive immune defenses against microbial…”
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A Quantitative Genetic Interaction Map of HIV Infection by Gordon, David E., Watson, Ariane, Roguev, Assen, Zheng, Simin, Jang, Gwendolyn M., Kane, Joshua, Xu, Jiewei, Guo, Jeffrey Z., Stevenson, Erica, Swaney, Danielle L., Franks-Skiba, Kathy, Verschueren, Erik, Shales, Michael, Crosby, David C., Frankel, Alan D., Marson, Alexander, Marazzi, Ivan, Cagney, Gerard, Krogan, Nevan J.

“…We have developed a platform for quantitative genetic interaction mapping using viral infectivity as a functional readout and constructed a viral…”
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ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection by Hüttenhain, Ruth, Xu, Jiewei, Burton, Lily A., Gordon, David E., Hultquist, Judd F., Johnson, Jeffrey R., Satkamp, Laura, Hiatt, Joseph, Rhee, David Y., Baek, Kheewoong, Crosby, David C., Frankel, Alan D., Marson, Alexander, Harper, J. Wade, Alpi, Arno F., Schulman, Brenda A., Gross, John D., Krogan, Nevan J.

“…The Cullin-RING E3 ligase (CRL) family is commonly hijacked by pathogens to redirect the host ubiquitin proteasome machinery to specific targets. During HIV…”
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Functional Segregation of Overlapping Genes in HIV by Fernandes, Jason D., Faust, Tyler B., Strauli, Nicolas B., Smith, Cynthia, Crosby, David C., Nakamura, Robert L., Hernandez, Ryan D., Frankel, Alan D.

“…Overlapping genes pose an evolutionary dilemma as one DNA sequence evolves under the selection pressures of multiple proteins. Here, we perform systematic…”
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Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling by Johnson, Jeffrey R., Crosby, David C., Hultquist, Judd F., Kurland, Andrew P., Adhikary, Prithy, Li, Donna, Marlett, John, Swann, Justine, Hüttenhain, Ruth, Verschueren, Erik, Johnson, Tasha L., Newton, Billy W., Shales, Michael, Simon, Viviana A., Beltrao, Pedro, Frankel, Alan D., Marson, Alexander, Cox, Jeffery S., Fregoso, Oliver I., Young, John A.T., Krogan, Nevan J.

“…Viruses must effectively remodel host cellular pathways to replicate and evade immune defenses, and they must do so with limited genomic coding capacity…”
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Identification and Optimization of Thienopyridine Carboxamides as Inhibitors of HIV Regulatory Complexes by Nakamura, Robert L, Burlingame, Mark A, Yang, Shumin, Crosby, David C, Talbot, Dale J, Chui, Kitty, Frankel, Alan D, Renslo, Adam R

“…Viral regulatory complexes perform critical functions during virus replication and are important targets for therapeutic intervention. In HIV, the Tat and Rev…”
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Design, Synthesis, and Biological Evaluation of Novel Hybrid Dicaffeoyltartaric/Diketo Acid and Tetrazole-Substituted l-Chicoric Acid Analogue Inhibitors of Human Immunodeficiency Virus Type 1 Integrase by Crosby, David C, Lei, Xiangyang, Gibbs, Charles G, McDougall, Brenda R, Robinson, W. Edward, Reinecke, Manfred G

“…Fourteen analogues of the anti-HIV-1 integrase (IN) inhibitor l-chicoric acid (L-CA) were prepared. Their IC50 values for 3′-end processing and strand transfer…”
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Mutagenesis of lysines 156 and 159 in human immunodeficiency virus type 1 integrase (IN) reveals differential interactions between these residues and different IN inhibitors by Crosby, David C, Lei, Xiangyang, Gibbs, Charles G, Reinecke, Manfred G, Robinson, Jr, W Edward

“…Human immunodeficiency virus (HIV) type I integrase (IN) active site, and viral DNA-binding residues K156 and K159 are predicted to interact both with strand…”
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The constitutionality of sobriety checkpoints in Alaska by Crosby, David C

“…Possible objections based on Fourth Amendment standards for privacy and search and seizure…”
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INSIDER TRADING ON THE OPEN MARKET: NONDISCLOSURE AND TEXAS GULF SULPHUR by Crosby, David C

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A manager's guide to gauge RR by Crosby, David C

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