Search Results - "Croote, Derek"

High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes by Croote, Derek, Darmanis, Spyros, Nadeau, Kari C, Quake, Stephen R

“…Immunoglobulin E (IgE) antibodies protect against helminth infections but can also cause life-threatening allergic reactions. Despite their role in human…”
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Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma by Darmanis, Spyros, Sloan, Steven A., Croote, Derek, Mignardi, Marco, Chernikova, Sophia, Samghababi, Peyman, Zhang, Ye, Neff, Norma, Kowarsky, Mark, Caneda, Christine, Li, Gordon, Chang, Steven D., Connolly, Ian David, Li, Yingmei, Barres, Ben A., Gephart, Melanie Hayden, Quake, Stephen R.

“…Glioblastoma (GBM) is the most common primary brain cancer in adults and is notoriously difficult to treat because of its diffuse nature. We performed…”
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Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics by Durham, Natasha D, Agrawal, Aditi, Waltari, Eric, Croote, Derek, Zanini, Fabio, Fouch, Mallorie, Davidson, Edgar, Smith, Olivia, Carabajal, Esteban, Pak, John E, Doranz, Benjamin J, Robinson, Makeda, Sanz, Ana M, Albornoz, Ludwig L, Rosso, Fernando, Einav, Shirit, Quake, Stephen R, McCutcheon, Krista M, Goo, Leslie

“…Eliciting broadly neutralizing antibodies (bNAbs) against the four dengue virus serotypes (DENV1-4) that are spreading into new territories is an important…”
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High fidelity hypothermic preservation of primary tissues in organ transplant preservative for single cell transcriptome analysis by Wang, Wanxin, Penland, Lolita, Gokce, Ozgun, Croote, Derek, Quake, Stephen R

“…High-fidelity preservation strategies for primary tissues are in great demand in the single cell RNAseq community. A reliable method would greatly expand the…”
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A human monoclonal antibody based immunoenzymetric assay to measure Fel d 1 concentrations in cat hair and pelt allergenic extracts by Rabin, Ronald L, Croote, Derek, Chen, Aaron, Dobrovolskaia, Ekaterina, Wong, Joyce Jia Wen, Grossman, Jessica, Hamilton, Robert G

“…In the United States, 19 allergen extracts of different specificities are standardized, which means that their potencies are determined in comparison to a US…”
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Correction: Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching by Horns, Felix, Vollmers, Christopher, Croote, Derek, Mackey, Sally F, Swan, Gary E, Dekker, Cornelia L, Davis, Mark M, Quake, Stephen R

“…Published 2, August 2016 In the originally published article, the primer sequences used for PCR amplification of immunoglobulin heavy chain genes (IGH) which…”
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Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching by Horns, Felix, Vollmers, Christopher, Croote, Derek, Mackey, Sally F, Swan, Gary E, Dekker, Cornelia L, Davis, Mark M, Quake, Stephen R

“…Antibody class switching is a feature of the adaptive immune system which enables diversification of the effector properties of antibodies. Even though class…”
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The Bruton's tyrosine kinase inhibitor acalabrutinib aborts ongoing IgE-mediated food-induced anaphylaxis in humanized mice by Vilela, Natalia, Croote, Derek, Dispenza, Melanie

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Addressing Complex Matrix Interference Improves Multiplex Food Allergen Detection by Targeted LC–MS/MS by Croote, Derek, Braslavsky, Ido, Quake, Stephen R

“…The frequent use of precautionary food allergen labeling (PAL) such as “may contain” frustrates allergic individuals who rely on such labeling to determine…”
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Cat Pelt/Hair Extract U.S. Potency: Updating the Predicate Fel d 1 RID with a mAb-based ELISA by Hamilton, Robert, Croote, Derek, Chen, Aaron, Dobrovolskaia, Katia, Grossman, Jessica, Rabin, Ronald

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Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris by Schaum, Nicholas, Karkanias, Jim, Neff, Norma F., May, Andrew P., Quake, Stephen R., Wyss-Coray, Tony, Darmanis, Spyros, Batson, Joshua, Botvinnik, Olga, Chen, Michelle B., Chen, Steven, Green, Foad, Jones, Robert, Maynard, Ashley, Penland, Lolita, Pisco, Angela Oliveira, Sit, Rene V., Stanley, Geoffrey M., Webber, James T., Zanini, Fabio, Baghel, Ankit S, Bakerman, Isaac, Bansal, Ishita, Berdnik, Daniela, Bilen, Biter, Brownfield, Douglas, Cain, Corey, Cho, Min, Cirolia, Giana, Conley, Stephanie D., Darmanis, Spyros, Demers, Aaron, Demir, Kubilay, de Morree, Antoine, Divita, Tessa, du Bois, Haley, Dulgeroff, Laughing Bear Torrez, Ebadi, Hamid, Espinoza, F. Hernán, Fish, Matt, Gan, Qiang, George, Benson M., Gillich, Astrid, Genetiano, Geraldine, Gu, Xueying, Gulati, Gunsagar S., Hang, Yan, Hosseinzadeh, Shayan, Huang, Albin, Iram, Tal, Isobe, Taichi, Ives, Feather, Kao, Kevin S., Karnam, Guruswamy, Kershner, Aaron M., Kiss, Bernhard M., Kong, William, Kumar, Maya E., Lam, Jonathan, Lee, Davis P., Lee, Song E., Li, Guang, Li, Qingyun, Liu, Ling, Lo, Annie, Lu, Wan-Jin, Manjunath, Anoop, May, Kaia L., May, Oliver L., McKay, Marina, Metzger, Ross J., Mignardi, Marco, Min, Dullei, Nabhan, Ahmad N., Ng, Katharine M., Noh, Joseph, Patkar, Rasika, Peng, Weng Chuan, Puccinelli, Robert, Rulifson, Eric J., Sikandar, Shaheen S., Sinha, Rahul, Szade, Krzysztof, Tan, Weilun, Tato, Cristina, Tellez, Krissie, Travaglini, Kyle J., Tropini, Carolina, Waldburger, Lucas, van Weele, Linda J., Wosczyna, Michael N., Xiang, Jinyi, Xue, Soso, Youngyunpipatkul, Justin, Zardeneta, Macy E., Zhang, Fan, Zhou, Lu, oungyunpipatkul, Justin Y, Castro, Paola, Croote, Derek

“…Here we present a compendium of single-cell transcriptomic data from the model organism Mus musculus that comprises more than 100,000 cells from 20 organs and…”
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IGNX001 Abrogates Peanut-mediated Mast Cell Degranulation and Murine Anaphylaxis by Croote, Derek, Wong, Joyce, Creeks, Paige, Aruva, Venu, Grossman, Jessica, Ferrini, Roger, Lowman, Henry, Landers, Jeffrey, O'Konek, Jessica, Thomas, Roger

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Blood from Highly Allergic Donors Yields High-Affinity IgE Antibodies to Food and Non-food Allergens by Croote, Derek, Creeks, Paige, Romero, Johanna, Sohail, Saba, Rodriguez, Robert Sanchez, Wong, Joyce

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Virus-inclusive single-cell RNA sequencing reveals the molecular signature of progression to severe dengue by Zanini, Fabio, Robinson, Makeda L., Croote, Derek, Sahoo, Malaya Kumar, Sanz, Ana Maria, Ortiz-Lasso, Eliana, Albornoz, Ludwig Luis, Rosso, Fernando, Montoya, Jose G., Goo, Leslie, Pinsky, Benjamin A., Quake, Stephen R., Einav, Shirit

“…Dengue virus (DENV) infection can result in severe complications. However, the understanding of the molecular correlates of severity is limited, partly due to…”
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Food allergen detection by mass spectrometry: the role of systems biology by Croote, Derek, Quake, Stephen R

“…Food allergy prevalence is rising worldwide, motivating the development of assays that can sensitively and reliably detect trace amounts of allergens in…”
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Evolution Toward Chip-Based Arrays in the Laboratory Diagnosis of Human Allergic Disease by Hamilton, Robert G., Croote, Derek, Lupinek, Christian, Matsson, Per

“…Multiplex-based specific IgE antibody assays have emerged into the clinical immunology laboratory through the combined use of pure, recombinant allergenic…”
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Cross-Reactive Shellfish-specific Monoclonal IgE Antibodies Discovered from Highly Allergic Individuals by Chung, Ben, Wong, Joyce, Aruva, Venu, Creeks, Paige, Romero, Johanna, Sohail, Saba, Mabery, Eric, Kaur, Anmoldeep, Thomas, Roger, Lowman, Henry, Croote, Derek

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Widespread monoclonal IgE antibody convergence to an immunodominant, proanaphylactic Ara h 2 epitope in peanut allergy by Croote, Derek, Wong, Joyce J W, Pecalvel, Cyprien, Leveque, Edouard, Casanovas, Natacha, Kamphuis, Jasper B J, Creeks, Paige, Romero, Johanna, Sohail, Saba, Bedinger, Daniel, Nadeau, Kari C, Chinthrajah, Rebecca S, Reber, Laurent L, Lowman, Henry B

“…Despite their central role in peanut allergy, human monoclonal IgE antibodies have eluded characterization. We sought to define the sequences, affinities,…”
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Preclinical efficacy of peanut-specific IgG4 antibody therapeutic IGNX001 by Croote, Derek, Wong, Joyce J.W., Creeks, Paige, Aruva, Venu, Landers, Jeffrey J., Kwok, Matthew, Jama, Zainab, Hamilton, Robert G., Santos, Alexandra F., O’Konek, Jessica J., Ferrini, Roger, Thomas, G. Roger, Lowman, Henry B.

“…Existing therapeutic strategies are challenged by long times to achieve effect and often require frequent administration. Peanut-allergic individuals would…”
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Immunocomplexed Antigen Capture and Identification by Native Top-Down Mass Spectrometry by McGee, John P., Melani, Rafael D., Des Soye, Ben, Croote, Derek, Winton, Valerie, Quake, Stephen R., Kafader, Jared O., Kelleher, Neil L.

“…Antibody–antigen interactions are central to the immune response. Variation of protein antigens such as isoforms and post-translational modifications can alter…”
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