Search Results - "Croom, Dallas K."

HIV Protease Inhibitors Stimulate Hepatic Triglyceride Synthesis by Lenhard, James M, Croom, Dallas K, Weiel, James E, Winegar, Deborah A

“…Abstract—Hyperlipidemia may complicate the use of HIV protease inhibitors (PIs) in AIDS therapy. To determine the cause of hyperlipidemia, the effect of PIs on…”
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Reduced serum dipeptidyl peptidase-IV after metformin and pioglitazone treatments by Lenhard, James M., Croom, Dallas K., Minnick, Dana T.

“…Dipeptidyl peptidase-IV (DPP-IV) regulates metabolism by degrading incretins involved in nutritional regulation. Metformin and pioglitazone improve insulin…”
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Discovery of 6,7-Dihydro‑5H‑pyrrolo[2,3‑a]pyrimidines as Orally Available G Protein-Coupled Receptor 119 Agonists by Katamreddy, Subba R, Carpenter, Andrew J, Ammala, Carina E, Boros, Eric E, Brashear, Ron L, Briscoe, Celia P, Bullard, Sarah R, Caldwell, Richard D, Conlee, Christopher R, Croom, Dallas K, Hart, Shane M, Heyer, Dennis O, Johnson, Paul R, Kashatus, Jennifer A, Minick, Doug J, Peckham, Gregory E, Ross, Sean A, Roller, Shane G, Samano, Vicente A, Sauls, Howard R, Tadepalli, Sarva M, Thompson, James B, Xu, Yun, Way, James M

“…GPR119 is a 7-transmembrane receptor that is expressed in the enteroendocrine cells in the intestine and in the islets of Langerhans in the pancreas. Indolines…”
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Optimization of 3-(1H-Indazol-3-ylmethyl)-1,5-benzodiazepines as Potent, Orally Active CCK-A Agonists by Henke, Brad R, Aquino, Christopher J, Birkemo, Larry S, Croom, Dallas K, Dougherty, Robert W, Ervin, Gregory N, Grizzle, Mary K, Hirst, Gavin C, James, Michael K, Johnson, Michael F, Queen, Kennedy L, Sherrill, Ronald G, Sugg, Elizabeth E, Suh, Edward M, Szewczyk, Jerzy W, Unwalla, Rayomand J, Yingling, Jeff, Willson, Timothy M

“…We previously described a series of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepine CCK-A agonists exemplified by compound 1 (GW 5823), which is the first…”
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Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity. 1. Optimization of the Agonist “Trigger” by Aquino, Christopher J, Armour, Duncan R, Berman, Judd M, Birkemo, Larry S, Carr, Robin A. E, Croom, Dallas K, Dezube, Milana, Dougherty, Robert W, Ervin, Gregory N, Grizzle, Mary K, Head, Julie E, Hirst, Gavin C, James, Michael K, Johnson, Michael F, Miller, Laurence J, Queen, Kennedy L, Rimele, Thomas J, Smith, David N, Sugg, Elizabeth E

“…Directed screening of compounds selected from the Glaxo registry file for contractile activity on the isolated guinea pig gallbladder (GPGB) identified a…”
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Dietary fat alters HIV protease inhibitor-induced metabolic changes in mice by Lenhard, J M, Croom, D K, Weiel, J E, Spaltenstein, A, Reynolds, D J, Furfine, E S

“…Human immunodeficiency virus (HIV) protease inhibitors (PI) may alter lipid metabolism in patients with acquired immunodeficiency syndrome (AIDS). However, the…”
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1,4-Benzodiazepine Peripheral Cholecystokinin (CCK-A) Receptor Agonists by Sherrill, Ronald G, Berman, Judd M, Birkemo, Lawrence, Croom, Dallas K, Dezube, Milana, Ervin, Gregory N, Grizzle, Mary K, James, Michael K, Johnson, Michael F, Queen, Kennedy L, Rimele, Thomas J, Vanmiddlesworth, Frank, Sugg, Elizabeth E

“…A series of 1,4-benzodiazepines, N-1-substituted with an N-isopropyl- N-phenylacetamide moiety, was synthesized and screened for CCK-A agonist activity. In…”
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Water Soluble Inhibitors of Topoisomerase I:  Quaternary Salt Derivatives of Camptothecin by Lackey, Karen, Sternbach, Daniel D, Croom, Dallas K, Emerson, David L, Evans, Michael G, Leitner, Peter L, Luzzio, Michael J, McIntyre, Gordon, Vuong, Alain, Yates, Julie, Besterman, Jeffrey M

“…Eleven water soluble 7-substituted quaternary ammonium salt derivatives of 10,11-(methylenedioxy)- and 10,11-(ethylenedioxy)-(20S)-camptothecin were…”
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3-(1H-Indazol-3-ylmethyl)-1,5-benzodiazepines:  CCK-A Agonists That Demonstrate Oral Activity as Satiety Agents by Henke, Brad R, Willson, Timothy M, Sugg, Elizabeth E, Croom, Dallas K, Dougherty, Robert W, Queen, Kennedy L, Birkemo, Larry S, Ervin, Gregory N, Grizzle, Mary K, Johnson, Michael F, James, Michael K

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3-[2-(N-Phenylacetamide)]-1,5-benzodiazepines:  Orally Active, Binding Selective CCK-A Agonists by Willson, Timothy M, Henke, Brad R, Momtahen, Tanya M, Myers, Peter L, Sugg, Elizabeth E, Unwalla, Rayomand J, Croom, Dallas K, Dougherty, Robert W, Grizzle, Mary K, Johnson, Michael F, Queen, Kennedy L, Rimele, Thomas J, Yingling, Jeffrey D, James, Michael K

“…A series of modifications were made to the C-3 substituent of the 1,5-benzodiazepine CCK-A agonist 1. Replacement of the inner urea NH and addition of a methyl…”
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Modification of Receptor Selectivity and Functional Activity in Cholecystokinin Peptoid Ligands by Dezube, Milana, Sugg, Elizabeth E, Birkemo, Larry S, Croom, Dallas K, Dougherty, Robert W, Ervin, Gregory N, Grizzle, Mary K, James, Michael K, Johnson, Michael F

“…Hybrid analogs of the cholecystokinin A (CCK-A) receptor selective tetrapeptide agonist Boc-Trp-Lys(Tac)-Asp-MePhe-NH2 (1,A-71623) and the CCK-B receptor…”
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Structure-Activity Relationships for Inhibition of Type 1 and 2 Human 5.alpha.-Reductase and Human Adrenal 3.beta.-Hydroxy-.DELTA.5-steroid Dehydrogenase/3-Keto-.DELTA.5-steroid Isomerase by 6-Azaandrost-4-en-3-ones: Optimization of the C17 Substituent by Frye, Stephen V, Haffner, Curt D, Maloney, Patrick R, Hiner, Roger N, Dorsey, George F, Noe, Robert A, Unwalla, Rayomand J, Batchelor, Kenneth W, Bramson, H. Neal, Stuart, J. Darren, Schweiker, Stephanie L, Van Arnold, John, Bickett, D. Mark, Moss, Marcia L, Tian, Gaochoa, Lee, Frank W, Tippin, Timothy K, James, Michael K, Grizzle, Mary K, Long, James E, Croom, Dallas K

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Discovery of 6,7-Dihydro-5 H -pyrrolo[2,3- a ]pyrimidines as Orally Available G Protein-Coupled Receptor 119 Agonists by Katamreddy, Subba R., Carpenter, Andrew J., Ammala, Carina E., Boros, Eric E., Brashear, Ron L., Briscoe, Celia P., Bullard, Sarah R., Caldwell, Richard D., Conlee, Christopher R., Croom, Dallas K., Hart, Shane M., Heyer, Dennis O., Johnson, Paul R., Kashatus, Jennifer A., Minick, Doug J., Peckham, Gregory E., Ross, Sean A., Roller, Shane G., Samano, Vicente A., Sauls, Howard R., Tadepalli, Sarva M., Thompson, James B., Xu, Yun, Way, James M.

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Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity (II):  Optimization of the C3 Amino Substituent by Hirst, Gavin C., Aquino, Christopher, Birkemo, Lawrence, Croom, Dallas K., Dezube, Milana, Dougherty, Robert W., Ervin, Gregory N., Grizzle, Mary K., Henke, Brad, James, Michael K., Johnson, Michael F., Momtahen, Tanya, Queen, Kennedy L., Sherrill, Ronald G., Szewczyk, Jerzy, Willson, Timothy M., Sugg, Elizabeth E.

“…Analogs of the previously reported 1,5-benzodiazepine peripheral cholecystokinin (CCK-A) receptor agonist 1 were prepared which explore substitution and/or…”
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