Search Results - "Crooks, Gay M."

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo by Crooks, Gay M, Gregory, Philip D, Cannon, Paula M, Holt, Nathalia, Kim, Kenneth, Friedman, Geoffrey, Taupin, Vanessa, Kohn, Donald B, Wang, Xingchao, Holmes, Michael C, Wang, Jianbin

“…Holt et al . describe an anti-HIV strategy in which human hematopoietic stem/progenitor cells are modified with zinc-finger nucleases to knock out the viral…”
Get full text

Stimulation of Hair Growth by Small Molecules that Activate Autophagy by Chai, Min, Jiang, Meisheng, Vergnes, Laurent, Fu, Xudong, de Barros, Stéphanie C., Doan, Ngan B., Huang, Wilson, Chu, Jessie, Jiao, Jing, Herschman, Harvey, Crooks, Gay M., Reue, Karen, Huang, Jing

“…Hair plays important roles, ranging from the conservation of body heat to the preservation of psychological well-being. Hair loss or alopecia affects millions…”
Get full text

Perivascular support of human hematopoietic stem/progenitor cells by Corselli, Mirko, Chin, Chee Jia, Parekh, Chintan, Sahaghian, Arineh, Wang, Wenyuan, Ge, Shundi, Evseenko, Denis, Wang, Xiaoyan, Montelatici, Elisa, Lazzari, Lorenza, Crooks, Gay M., Péault, Bruno

“…Hematopoietic stem and progenitor cells (HSPCs) emerge and develop adjacent to blood vessel walls in the yolk sac, aorta-gonad-mesonephros region, embryonic…”
Get full text

Critical Differences in Hematopoiesis and Lymphoid Development between Humans and Mice by Parekh, Chintan, Crooks, Gay M.

“…During the last five decades, elegant mouse models of hematopoiesis have yielded most of the seminal insights into this complex biological system of…”
Get full text

Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells by Evseenko, Denis, Zhu, Yuhua, Schenke-Layland, Katja, Kuo, Jeffrey, Latour, Brooke, Ge, Shundi, Scholes, Jessica, Dravid, Gautam, Li, Xinmin, MacLellan, W. Robb, Crooks, Gay M., Witte, Owen N.

“…Our understanding of how mesodermal tissue is formed has been limited by the absence of specific and reliable markers of early mesoderm commitment. We report…”
Get full text

Dynamics of HSPC Repopulation in Nonhuman Primates Revealed by a Decade-Long Clonal-Tracking Study by Kim, Sanggu, Kim, Namshin, Presson, Angela P., Metzger, Mark E., Bonifacino, Aylin C., Sehl, Mary, Chow, Samson A., Crooks, Gay M., Dunbar, Cynthia E., An, Dong Sung, Donahue, Robert E., Chen, Irvin S.Y.

“…In mice, clonal tracking of hematopoietic stem cells (HSCs) has revealed variations in repopulation characteristics. However, it is unclear whether similar…”
Get full text

Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity by Abt, Evan R, Rashid, Khalid, Le, Thuc M, Li, Suwen, Lee, Hailey R, Lok, Vincent, Li, Luyi, Creech, Amanda L, Labora, Amanda N, Mandl, Hanna K, Lam, Alex K, Cho, Arthur, Rezek, Valerie, Wu, Nanping, Abril-Rodriguez, Gabriel, Rosser, Ethan W, Mittelman, Steven D, Hugo, Willy, Mehrling, Thomas, Bantia, Shanta, Ribas, Antoni, Donahue, Timothy R, Crooks, Gay M, Wu, Ting-Ting, Radu, Caius G

“…Purine nucleoside phosphorylase (PNP) enables the breakdown and recycling of guanine nucleosides. PNP insufficiency in humans is paradoxically associated with…”
Get full text

Strength of CAR signaling determines T cell versus ILC differentiation from pluripotent stem cells by Li, Suwen, Wang, Chloe S., Montel-Hagen, Amélie, Chen, Ho-Chung, Lopez, Shawn, Zhou, Olivia, Dai, Kristy, Tsai, Steven, Satyadi, William, Botero, Carlos, Wong, Claudia, Casero, David, Crooks, Gay M., Seet, Christopher S.

“…Generation of chimeric antigen receptor (CAR) T cells from pluripotent stem cells (PSCs) will enable advances in cancer immunotherapy. Understanding how CARs…”
Get full text

The Metabolic Landscape of Thymic T Cell Development In Vivo and In Vitro by Sun, Victoria, Sharpley, Mark, Kaczor-Urbanowicz, Karolina E, Chang, Patrick, Montel-Hagen, Amélie, Lopez, Shawn, Zampieri, Alexandre, Zhu, Yuhua, de Barros, Stéphanie C, Parekh, Chintan, Casero, David, Banerjee, Utpal, Crooks, Gay M

“…Although metabolic pathways have been shown to control differentiation and activation in peripheral T cells, metabolic studies on thymic T cell development are…”
Get full text

Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy by Hsieh, Yao-Te, Gang, Eun Ji, Geng, Huimin, Park, Eugene, Huantes, Sandra, Chudziak, Doreen, Dauber, Katrin, Schaefer, Paul, Scharman, Carlton, Shimada, Hiroyuki, Shojaee, Seyedmehdi, Klemm, Lars, Parameswaran, Reshmi, Loh, Mignon, Kang, Eun-Suk, Koo, Hong Hoe, Hofmann, Wolf-Karsten, Andrade, Jacob, Crooks, Gay M., Willman, Cheryl L., Müschen, Markus, Papayannopoulou, Thalia, Heisterkamp, Nora, Bönig, Halvard, Kim, Yong-Mi

“…Bone marrow (BM) provides chemoprotection for acute lymphoblastic leukemia (ALL) cells, contributing to lack of efficacy of current therapies. Integrin alpha4…”
Get full text

Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy by Li, Yan-Ruide, Zhou, Yang, Kim, Yu Jeong, Zhu, Yanni, Ma, Feiyang, Yu, Jiaji, Wang, Yu-Chen, Chen, Xianhui, Li, Zhe, Zeng, Samuel, Wang, Xi, Lee, Derek, Ku, Josh, Tsao, Tasha, Hardoy, Christian, Huang, Jie, Cheng, Donghui, Montel-Hagen, Amélie, Seet, Christopher S., Crooks, Gay M., Larson, Sarah M., Sasine, Joshua P., Wang, Xiaoyan, Pellegrini, Matteo, Ribas, Antoni, Kohn, Donald B., Witte, Owen, Wang, Pin, Yang, Lili

“…Cell-based immunotherapy has become the new-generation cancer medicine, and “off-the-shelf” cell products that can be manufactured at large scale and…”
Get full text

High Interferon Signature Leads to Increased STAT1/3/5 Phosphorylation in PBMCs From SLE Patients by Single Cell Mass Cytometry by Yiu, Gloria, Rasmussen, Tue Kruse, Tsai, Brandon L, Diep, Vivian K, Haddon, David J, Tsoi, Jennifer, Miller, Gopika D, Comin-Anduix, Begoña, Deleuran, Bent, Crooks, Gay M, Utz, Paul J

“…The establishment of an "interferon (IFN) signature" to subset SLE patients on disease severity has led to therapeutics targeting IFNα. Here, we investigate…”
Get full text

Human Developmental Chondrogenesis as a Basis for Engineering Chondrocytes from Pluripotent Stem Cells by Wu, Ling, Bluguermann, Carolina, Kyupelyan, Levon, Latour, Brooke, Gonzalez, Stephanie, Shah, Saumya, Galic, Zoran, Ge, Sundi, Zhu, Yuhua, Petrigliano, Frank A., Nsair, Ali, Miriuka, Santiago G., Li, Xinmin, Lyons, Karen M., Crooks, Gay M., McAllister, David R., Van Handel, Ben, Adams, John S., Evseenko, Denis

“…Joint injury and osteoarthritis affect millions of people worldwide, but attempts to generate articular cartilage using adult stem/progenitor cells have been…”
Get full text

Lentiviral vectors for precise expression to treat X-linked lymphoproliferative disease by Ayoub, Paul G., Gensheimer, Julia, Lathrop, Lindsay, Juett, Colin, Quintos, Jason, Tam, Kevin, Reid, Jack, Ma, Feiyang, Tam, Curtis, McAuley, Grace E., Brown, Devin, Wu, Xiaomeng, Zhang, Ruixue, Bradford, Kathryn, Hollis, Roger P., Crooks, Gay M., Kohn, Donald B.

“…X-linked lymphoproliferative disease (XLP1) results from SH2D1A gene mutations affecting the SLAM-associated protein (SAP). A regulated lentiviral vector (LV),…”
Get full text

The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2) by Berent-Maoz, Beata, Montecino-Rodriguez, Encarnacion, Fice, Michael, Casero, David, Seet, Christopher S, Crooks, Gay M, Lowry, William, Dorshkind, Kenneth

“…Cell number in the mouse thymus increases steadily during the first two weeks after birth. It then plateaus and begins to decline by seven weeks after birth…”
Get full text

Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment by Evseenko, Denis, Latour, Brooke, Richardson, Wade, Corselli, Mirko, Sahaghian, Arineh, Cardinal, Sofie, Zhu, Yuhua, Chan, Rebecca, Dunn, Bruce, Crooks, Gay M

“…Lysophosphatidic acid (LPA) is a pleiotropic phospholipid present in the blood and certain tissues at high concentrations; its diverse effects are mediated…”
Get full text

Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A–deficient mice by Rountree, C. Bart, Senadheera, Shantha, Mato, Jose M., Crooks, Gay M., Lu, Shelly C.

“…Methionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the biosynthesis of S‐adenosylmethionine. Hepatic MAT activity falls in chronic…”
Get full text

Nidogen‐1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration by Zbinden, Aline, Layland, Shannon L., Urbanczyk, Max, Carvajal Berrio, Daniel A., Marzi, Julia, Zauner, Monika, Hammerschmidt, Anne, Brauchle, Eva M., Sudrow, Katrin, Fink, Simon, Templin, Markus, Liebscher, Simone, Klein, Gerd, Deb, Arjun, Duffy, Garry P., Crooks, Gay M., Eble, Johannes A., Mikkola, Hanna K. A., Nsair, Ali, Seifert, Martina, Schenke‐Layland, Katja

“…Ischemia impacts multiple organ systems and is the major cause of morbidity and mortality in the developed world. Ischemia disrupts tissue homeostasis, driving…”
Get full text

Transcriptionally and Functionally Distinct Mesenchymal Subpopulations Are Generated from Human Pluripotent Stem Cells by Chin, Chee Jia, Li, Suwen, Corselli, Mirko, Casero, David, Zhu, Yuhua, He, Chong Bin, Hardy, Reef, Péault, Bruno, Crooks, Gay M.

“…Various mesenchymal cell types have been identified as critical components of the hematopoietic stem/progenitor cell (HSPC) niche. Although several groups have…”
Get full text

Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7− lympho-myeloid thymic progenitors by Hao, Qian-Lin, George, Aswathi A., Zhu, Judy, Barsky, Lora, Zielinska, Ewa, Wang, Xiuli, Price, Mary, Ge, Shundi, Crooks, Gay M.

“…The identity and lineage potential of the cells that initiate thymopoiesis remain controversial. The goal of these studies was to determine, at a clonal level,…”
Get full text