Search Results - "Cronin, James G"

Tolerance and Innate Immunity Shape the Development of Postpartum Uterine Disease and the Impact of Endometritis in Dairy Cattle by Sheldon, I. Martin, Cronin, James G, Bromfield, John J

“…Bacteria are ubiquitous in the bovine uterus after parturition, but 50 years ago, cows tolerated these bacteria and few animals developed uterine disease. Now,…”
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Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation by Jones, Nicholas, Blagih, Julianna, Zani, Fabio, Rees, April, Hill, David G., Jenkins, Benjamin J., Bull, Caroline J., Moreira, Diana, Bantan, Azari I. M., Cronin, James G., Avancini, Daniele, Jones, Gareth W., Finlay, David K., Vousden, Karen H., Vincent, Emma E., Thornton, Catherine A.

“…Fructose intake has increased substantially throughout the developed world and is associated with obesity, type 2 diabetes and non-alcoholic fatty liver…”
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Epithelial and Stromal Cells of Bovine Endometrium Have Roles in Innate Immunity and Initiate Inflammatory Responses to Bacterial Lipopeptides In Vitro via Toll-Like Receptors TLR2, TLR1, and TLR6 by Turner, Matthew L, Cronin, James G, Healey, Gareth D, Sheldon, Iain Martin

“…Bacteria often infect the endometrium of cattle to cause endometritis, uterine disease, and infertility. Lipopeptides are commonly found among bacteria and are…”
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Macrophage Plasticity in Reproduction and Environmental Influences on Their Function by Chambers, Megan, Rees, April, Cronin, James G, Nair, Manju, Jones, Nicholas, Thornton, Catherine A

“…Macrophages are key components of the innate immune system and exhibit extensive plasticity and heterogeneity. They play a significant role in the non-pregnant…”
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Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation by Jones, Nicholas, Vincent, Emma E., Cronin, James G., Panetti, Silvia, Chambers, Megan, Holm, Sean R., Owens, Sian E., Francis, Nigel J., Finlay, David K., Thornton, Catherine A.

“…Metabolic pathways that regulate T-cell function show promise as therapeutic targets in diverse diseases. Here, we show that at rest cultured human effector…”
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Innate immunity and inflammation of the bovine female reproductive tract in health and disease by Sheldon, I Martin, Cronin, James G, Healey, Gareth D, Gabler, Christoph, Heuwieser, Wolfgang, Streyl, Dominik, Bromfield, John J, Miyamoto, Akio, Fergani, Chrys, Dobson, Hilary

“…Mammalian reproductive physiology and the development of viviparity co-evolved with inflammation and immunity over millennia. Many inflammatory mediators…”
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Endometrial cells sense and react to tissue damage during infection of the bovine endometrium via interleukin 1 by Healy, Laura L., Cronin, James G., Sheldon, I. Martin

“…Cells generate inflammatory responses to bacteria when pattern recognition receptors bind pathogen-associated molecules such as lipopolysaccharide. Cells may…”
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Conceptus-induced, interferon tau-dependent gene expression in bovine endometrial epithelial and stromal cells by Chaney, Heather L., Grose, Lindsay F., Charpigny, Gilles, Behura, Susanta K., Sheldon, I. Martin, Cronin, James G., Lonergan, Patrick, Spencer, Thomas E., Mathew, Daniel J.

“…Bovine endometrium consists of epithelial and stromal cells that respond to conceptus interferon tau (IFNT), the maternal recognition of pregnancy (MRP)…”
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Metabolic Adaptation of Human CD4 + and CD8 + T-Cells to T-Cell Receptor-Mediated Stimulation by Jones, Nicholas, Cronin, James G, Dolton, Garry, Panetti, Silvia, Schauenburg, Andrea J, Galloway, Sarah A E, Sewell, Andrew K, Cole, David K, Thornton, Catherine A, Francis, Nigel J

“…Linking immunometabolic adaptation to T-cell function provides insight for the development of new therapeutic approaches in multiple disease settings. T-cell…”
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A Pedagogy of Slow: Integrating Experiences of Physical and Virtual Gallery Spaces to Foster Critical Engagement in SoTL by Supple, Briony, Cronin, James G. R.

“…This article makes a case for SoTL practitioners to engage in what we term a pedagogy of slow. Here, “slow” connotes with waiting and patience. It takes time…”
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Glucose Availability and AMP-Activated Protein Kinase Link Energy Metabolism and Innate Immunity in the Bovine Endometrium by Turner, Matthew L, Cronin, James G, Noleto, Pablo G, Sheldon, I Martin

“…Defences against the bacteria that usually infect the endometrium of postpartum cattle are impaired when there is metabolic energy stress, leading to…”
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Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins by Ormsby, Thomas J R, Owens, Sian E, Clement, Liam, Mills, Tom J, Cronin, James G, Bromfield, John J, Sheldon, Iain Martin

“…Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form pores in cell membranes. Membrane pores facilitate infection by…”
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Phytochemical Targeting of STAT3 Orchestrated Lipid Metabolism in Therapy-Resistant Cancers by Tse, Carmen, Warner, Ashleigh, Farook, Rufaik, Cronin, James G

“…Lipids are critical for maintaining homeostasis and cellular metabolism. However, the dysregulation of lipid metabolism contributes to the pathogenesis of…”
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Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer by Farook, M. Rufaik, Croxford, Zack, Morgan, Steffan, Horlock, Anthony D., Holt, Amy K., Rees, April, Jenkins, Benjamin J., Tse, Carmen, Stanton, Emma, Davies, D. Mark, Thornton, Catherine A., Jones, Nicholas, Sheldon, I. Martin, Vincent, Emma E., Cronin, James G.

“…The pyruvate transporter MPC1 (mitochondrial pyruvate carrier 1) acts as a tumour-suppressor, loss of which correlates with a pro-tumorigenic phenotype and…”
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Glucocorticoids increase tissue cell protection against pore-forming toxins from pathogenic bacteria by Ormsby, Thomas J. R., Owens, Sian E., Turner, Matthew L., Cronin, James G., Bromfield, John J., Sheldon, I. Martin

“…Many species of pathogenic bacteria damage tissue cells by secreting toxins that form pores in plasma membranes. Here we show that glucocorticoids increase the…”
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Polarized Epithelial Cells Secrete Interleukin 6 Apically in the Bovine Endometrium1 by Healy, Laura L, Cronin, James G, Sheldon, I. Martin

“…Endometrial epithelial cells are the first line of defense against pathogenic bacteria infecting the uterus. Innate immune responses by these polarized…”
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Beyond the conference: Singing our SSONG by Green, Corinne A., Eady, Michelle J., McCarthy, Marian, Akenson, Ashley B., Supple, Briony, McKeon, Jacinta, Cronin, James G. R.

“…The International Society for the Scholarship of Teaching and Learning (ISSOTL) annual conference presents an exciting opportunity to meet with international…”
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Coordinated Role of Toll-Like Receptor-3 and Retinoic Acid-Inducible Gene-I in the Innate Response of Bovine Endometrial Cells to Virus by Carneiro, Luisa C, Bedford, Carmen, Jacca, Sarah, Rosamilia, Alfonso, de Lima, Vera F, Donofrio, Gaetano, Sheldon, I Martin, Cronin, James G

“…Bovine herpesvirus-4 (BoHV-4) and bovine viral diarrhea virus (BVDV) infect the uterus of cattle, often resulting in reduced fertility, or abortion of the…”
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Dynasore - not just a dynamin inhibitor by Preta, Giulio, Cronin, James G, Sheldon, I Martin

“…Dynamin is a GTPase protein that is essential for membrane fission during clathrin-mediated endocytosis in eukaryotic cells. Dynasore is a GTPase inhibitor…”
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Symposium review: Mechanisms linking metabolic stress with innate immunity in the endometrium by Sheldon, I Martin, Cronin, James G, Pospiech, Mateusz, Turner, Matthew L

“…Bacterial infections of the uterus after parturition are ubiquitous in dairy cattle and often cause uterine disease, such as metritis or endometritis. However,…”
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