Search Results - "Cronin, Ciarán N."

Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus by LOVE, Robert A, BRODSKY, Oleg, HICKEY, Michael J, WELLS, Peter A, CRONIN, Ciaran N

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Optimization of genetic code expansion in the baculovirus expression vector system (BEVS) by Cronin, Ciarán N.

“…The production of recombinant proteins containing unnatural amino acids, commonly known as genetic code expansion (GCE), represents a breakthrough in protein…”
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Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation by Pemovska, Tea, Johnson, Eric, Kontro, Mika, Repasky, Gretchen A., Chen, Jeffrey, Wells, Peter, Cronin, Ciarán N., McTigue, Michele, Kallioniemi, Olli, Porkka, Kimmo, Murray, Brion W., Wennerberg, Krister

“…A large ex vivo screen of approved and investigational anti-cancer drugs in primary cells derived from CML and ALL patients identifies axitinib, a VEGFR…”
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High-volume shake flask cultures as an alternative to cellbag technology for recombinant protein production in the baculovirus expression vector system (BEVS) by Cronin, Ciarán N.

“…Recombinant protein production in the baculovirus expression vector system (BEVS) has emerged as a system of choice for the production of recombinant human…”
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Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation by Johnson, Eric, McTigue, Michele, Gallego, Rebecca A., Johnson, Ted W., Timofeevski, Sergei, Maestre, Michael, Fisher, Timothy S., Kania, Robert, Sawasdikosol, Sansana, Burakoff, Steven, Cronin, Ciarán N.

“…Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) is a Ser/Thr kinase that operates via the c-Jun N-terminal kinase (JNK) and extracellular signal-regulated…”
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Dissecting Parameters Contributing to the Underprediction of Aldehyde Oxidase-Mediated Metabolic Clearance of Drugs by Subash, Sandhya, Singh, Dilip K, Ahire, Deepak S, Khojasteh, S Cyrus, Murray, Bernard P, Zientek, Michael A, Jones, Robert S, Kulkarni, Priyanka, Smith, Bill J, Heyward, Scott, Cronin, Ciarán N, Prasad, Bhagwat

“…We investigated the effect of variability and instability in aldehyde oxidase (AO) content and activity on the scaling of in vitro metabolism data. AO content…”
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Production of active recombinant human aldehyde oxidase (AOX) in the baculovirus expression vector system (BEVS) and deployment in a pre-clinical fraction-of-control AOX compound exposure assay by Cronin, Ciarán N., Liu, JianHua, Grable, Nicole, Strelevitz, Timothy J., Obach, R. Scott, Carlo, Anthony

“…Human aldehyde oxidase (AOX) has emerged as a key enzyme activity for consideration in modern drug discovery. The enzyme catalyzes the oxidation of a wide…”
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Synthesis of Deuterated Heterocycles with Me2NCD(OMe)2 and Evaluation of the Products for Metabolism by Aldehyde Oxidase by Choi, Chulho, Carlo, Anthony A, Cronin, Ciarán N, Jing, Konghua, Kung, Daniel W, Liu, Jianhua, Lombardo, Vincent M, Turco, Abigail R, Yin, Juxing, Yu, Aijia, Wright, Stephen W

“…The metabolic oxidation of drug-like small molecules by aldehyde oxidase (AO) has commonly been mitigated through the incorporation of deuterium at the…”
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Biochemical Characterization of Recombinant Hepatitis C Virus Nonstructural Protein 4B: Evidence for ATP/GTP Hydrolysis and Adenylate Kinase Activity by Thompson, Aaron A, Zou, Aihua, Yan, Jiangli, Duggal, Rohit, Hao, Weidong, Molina, David, Cronin, Ciarán N, Wells, Peter A

“…While nonstructural protein 4B (NS4B) from hepatitis C virus (HCV) is absolutely required for viral propagation, a full understanding of the enzymatic…”
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Production of selenomethionyl‐derivatized proteins in baculovirus‐infected insect cells by Cronin, Ciarán N., Lim, Kheng B., Rogers, Joe

“…A protocol is described for the production of both intracellularly expressed and secreted selenomethionyl‐derivatized recombinant proteins in…”
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Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system by Caspers, Nicole L., Han, Seungil, Rajamohan, Francis, Hoth, Lise R., Geoghegan, Kieran F., Subashi, Timothy A., Vazquez, Michael L., Kaila, Neelu, Cronin, Ciarán N., Johnson, Eric, Kurumbail, Ravi G.

“…Crystals of phosphorylated JAK1 kinase domain were initially generated in complex with nucleotide (ADP) and magnesium. The tightly bound Mg2+‐ADP at the…”
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Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation by Mol, Clifford D., Lim, Kheng B., Sridhar, Vandana, Zou, Hua, Chien, Ellen Y.T., Sang, Bi-Ching, Nowakowski, Jacek, Kassel, Daniel B., Cronin, Ciarán N., McRee, Duncan E.

“…The c-Kit proto-oncogene is a receptor protein-tyrosine kinase associated with several highly malignant human cancers. Upon binding its ligand, stem cell…”
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Structures of the Cancer-Related Aurora-A, FAK, and EphA2 Protein Kinases from Nanovolume Crystallography by Nowakowski, Jacek, Cronin, Ciarán N., McRee, Duncan E., Knuth, Mark W., Nelson, Christian G., Pavletich, Nikola P., Rogers, Joe, Sang, Bi-Ching, Scheibe, Daniel N., Swanson, Ronald V., Thompson, Devon A.

“…Protein kinases are important drug targets in human cancers, inflammation, and metabolic diseases. This report presents the structures of kinase domains for…”
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Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1 by Schnute, Mark E, McReynolds, Matthew D, Kasten, Tom, Yates, Matthew, Jerome, Gina, Rains, John W, Hall, Troii, Chrencik, Jill, Kraus, Michelle, Cronin, Ciaran N, Saabye, Matthew, Highkin, Maureen K, Broadus, Richard, Ogawa, Shinji, Cukyne, Kristin, Zawadzke, Laura E, Peterkin, Vincent, Iyanar, Kaliapan, Scholten, Jeffrey A, Wendling, Jay, Fujiwara, Hideji, Nemirovskiy, Olga, Wittwer, Arthur J, Nagiec, Marek M

“…SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes…”
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Economical parallel protein expression screening and scale-up in Escherichia coli by Brodsky, Oleg, Cronin, Ciarán N

“…A novel microfermentation and scale-up platform for parallel protein production in Escherichia coli is described. The vertical shaker device Vertiga, which…”
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Corrigendum to ‘Production of active recombinant human aldehyde oxidase (AOX) in the baculovirus expression vector system (BEVS) and deployment in a pre-clinical fraction-of-control AOX compound exposure assay’ [Protein Expr. Purif. 177 (2020) 105749] by Cronin, Ciarán N., Liu, JianHua, Grable, Nicole, Strelevitz, Timothy J., Obach, R. Scott, Carlo, Anthony

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Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers by Qiu, Luping, Levine, Kymberly, Gajiwala, Ketan S, Cronin, Ciarán N, Nagata, Asako, Johnson, Eric, Kraus, Michelle, Tatlock, John, Kania, Robert, Foley, Timothy, Sun, Shaoxian

“…Protein tyrosine kinase 6 (PTK6, or BRK) is aberrantly expressed in breast cancers, and emerging as an oncogene that promotes tumor cell proliferation,…”
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Synthesis of Deuterated Heterocycles with Me 2 NCD(OMe) 2 and Evaluation of the Products for Metabolism by Aldehyde Oxidase by Choi, Chulho, Carlo, Anthony A, Cronin, Ciarán N, Jing, Konghua, Kung, Daniel W, Liu, Jianhua, Lombardo, Vincent M, Turco, Abigail R, Yin, Juxing, Yu, Aijia, Wright, Stephen W

“…The metabolic oxidation of drug-like small molecules by aldehyde oxidase (AO) has commonly been mitigated through the incorporation of deuterium at the…”
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Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain by Bagal, Sharan K, Andrews, Mark, Bechle, Bruce M, Bian, Jianwei, Bilsland, James, Blakemore, David C, Braganza, John F, Bungay, Peter J, Corbett, Matthew S, Cronin, Ciaran N, Cui, Jingrong Jean, Dias, Rebecca, Flanagan, Neil J, Greasley, Samantha E, Grimley, Rachel, James, Kim, Johnson, Eric, Kitching, Linda, Kraus, Michelle L, McAlpine, Indrawan, Nagata, Asako, Ninkovic, Sacha, Omoto, Kiyoyuki, Scales, Stephanie, Skerratt, Sarah E, Sun, Jianmin, Tran-Dubé, Michelle, Waldron, Gareth J, Wang, Fen, Warmus, Joseph S

“…Hormones of the neurotrophin family, nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4), are…”
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Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays by Hofler, Alexandra, Nichols, Tim, Grant, Stephan, Lingardo, Laura, Esposito, Edward A., Gridley, Scott, Murphy, Sean T., Kath, John C., Cronin, Ciarán N., Kraus, Michelle, Alton, Gordon, Xie, Zhi, Sutton, Scott, Gehring, Mike, Ermolieff, Jacques

“…The PI3K/AKT signaling pathway has an important regulatory role in cancer cell growth and tumorigenesis. Signal transduction through this pathway requires the…”
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