Search Results - "Cronan, Mark R."

In the Thick of It: Formation of the Tuberculous Granuloma and Its Effects on Host and Therapeutic Responses by Cronan, Mark R

“…The defining pathology of tuberculosis is the granuloma, an organized structure derived from host immune cells that surrounds infecting . As the location of…”
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The Macrophage-Specific Promoter mfap4 Allows Live, Long-Term Analysis of Macrophage Behavior during Mycobacterial Infection in Zebrafish by Walton, Eric M, Cronan, Mark R, Beerman, Rebecca W, Tobin, David M

“…Transgenic labeling of innate immune cell lineages within the larval zebrafish allows for real-time, in vivo analyses of microbial pathogenesis within a…”
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Fit for consumption: zebrafish as a model for tuberculosis by Cronan, Mark R, Tobin, David M

“…Despite efforts to generate new vaccines and antibiotics for tuberculosis, the disease remains a public health problem worldwide. The zebrafish Danio rerio has…”
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Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection by Cronan, Mark R., Beerman, Rebecca W., Rosenberg, Allison F., Saelens, Joseph W., Johnson, Matthew G., Oehlers, Stefan H., Sisk, Dana M., Jurcic Smith, Kristen L., Medvitz, Neil A., Miller, Sara E., Trinh, Le A., Fraser, Scott E., Madden, John F., Turner, Joanne, Stout, Jason E., Lee, Sunhee, Tobin, David M.

“…Mycobacterium tuberculosis infection in humans triggers formation of granulomas, which are tightly organized immune cell aggregates that are the central…”
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In vivo fluorescence lifetime imaging of macrophage intracellular metabolism during wound responses in zebrafish by Miskolci, Veronika, Tweed, Kelsey E, Lasarev, Michael R, Britt, Emily C, Walsh, Alex J, Zimmerman, Landon J, McDougal, Courtney E, Cronan, Mark R, Fan, Jing, Sauer, John-Demian, Skala, Melissa C, Huttenlocher, Anna

“…The function of macrophages in vitro is linked to their metabolic rewiring. However, macrophage metabolism remains poorly characterized in situ. Here, we used…”
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Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection by Matty, Molly A, Knudsen, Daphne R, Walton, Eric M, Beerman, Rebecca W, Cronan, Mark R, Pyle, Charlie J, Hernandez, Rafael E, Tobin, David M

“…is the leading worldwide cause of death due to a single infectious agent. Existing anti-tuberculous therapies require long treatments and are complicated by…”
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A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites by Jiang, Nan, Rasmussen, Jeffrey P, Clanton, Joshua A, Rosenberg, Marci F, Luedke, Kory P, Cronan, Mark R, Parker, Edward D, Kim, Hyeon-Jin, Vaughan, Joshua C, Sagasti, Alvaro, Parrish, Jay Z

“…Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate…”
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CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections by Cronan, Mark R, Rosenberg, Allison F, Oehlers, Stefan H, Saelens, Joseph W, Sisk, Dana M, Jurcic Smith, Kristen L, Lee, Sunhee, Tobin, David M

“…Visualization of infection and the associated host response has been challenging in adult vertebrates. Owing to their transparency, zebrafish larvae have been…”
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Identification of a Specific Granular Marker of Zebrafish Eosinophils Enables Development of New Tools for Their Study by Herbert, Miriam, Goosmann, Christian, Brinkmann, Volker, Dimmler, Christiane, Cronan, Mark R

“…Eosinophils control many aspects of the vertebrate innate immune response. They contribute to homeostasis, inflammatory conditions and defense against…”
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A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization by Cronan, Mark R., Hughes, Erika J., Brewer, W. Jared, Viswanathan, Gopinath, Hunt, Emily G., Singh, Bindu, Mehra, Smriti, Oehlers, Stefan H., Gregory, Simon G., Kaushal, Deepak, Tobin, David M.

“…The central pathogen-immune interface in tuberculosis is the granuloma, a complex host immune structure that dictates infection trajectory and physiology…”
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Interception of host angiogenic signalling limits mycobacterial growth by Oehlers, Stefan H., Cronan, Mark R., Scott, Ninecia R., Thomas, Monica I., Okuda, Kazuhide S., Walton, Eric M., Beerman, Rebecca W., Crosier, Philip S., Tobin, David M.

“…Using a model of tuberculosis in zebrafish, granuloma formation is shown to coincide with hypoxia and angiogenesis; furthermore, the pharmacological inhibition…”
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Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice by Bohrer, Andrea C, Castro, Ehydel, Hu, Zhidong, Queiroz, Artur T L, Tocheny, Claire E, Assmann, Maike, Sakai, Shunsuke, Nelson, Christine, Baker, Paul J, Ma, Hui, Wang, Lin, Zilu, Wen, du Bruyn, Elsa, Riou, Catherine, Kauffman, Keith D, Moore, Ian N, Del Nonno, Franca, Petrone, Linda, Goletti, Delia, Martineau, Adrian R, Lowe, David M, Cronan, Mark R, Wilkinson, Robert J, Barry, Clifton E, Via, Laura E, Barber, Daniel L, Klion, Amy D, Andrade, Bruno B, Song, Yanzheng, Wong, Ka-Wing, Mayer-Barber, Katrin D

“…Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the activities of multiple leukocyte subsets, yet the roles of the different innate…”
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An explant technique for high-resolution imaging and manipulation of mycobacterial granulomas by Cronan, Mark R., Matty, Molly A., Rosenberg, Allison F., Blanc, Landry, Pyle, Charlie J., Espenschied, Scott T., Rawls, John F., Dartois, Véronique, Tobin, David M.

“…A central and critical structure in tuberculosis, the mycobacterial granuloma consists of highly organized immune cells, including macrophages that drive…”
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Adventures within the speckled band: heterogeneity, angiogenesis, and balanced inflammation in the tuberculous granuloma by Matty, Molly A., Roca, Francisco J., Cronan, Mark R., Tobin, David M.

“…Summary Recent work in a variety of animal models, including mice, zebrafish, and macaques, as well as in humans, has led to a reassessment of several tenets…”
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Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling by Walton, Eric M., Cronan, Mark R., Cambier, C.J., Rossi, Andrea, Marass, Michele, Foglia, Matthew D., Brewer, W. Jared, Poss, Kenneth D., Stainier, Didier Y.R., Bertozzi, Carolyn R., Tobin, David M.

“…Mycobacterial infection leads to the formation of characteristic immune aggregates called granulomas, a process accompanied by dramatic remodeling of the host…”
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Infection-Induced Vascular Permeability Aids Mycobacterial Growth by Oehlers, Stefan H., Cronan, Mark R., Beerman, Rebecca W., Johnson, Matthew G., Huang, Jianhua, Kontos, Christopher D., Stout, Jason E., Tobin, David M.

“…Pathogenic mycobacteria trigger formation of organized granulomas. As granulomas mature, they induce angiogenesis and vascular permeability. Here, in a…”
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Epithelial delamination is protective during pharmaceutical-induced enteropathy by Espenschied, Scott T., Cronan, Mark R., Matty, Molly A., Mueller, Olaf, Redinbo, Matthew R., Tobin, David M., Rawls, John F.

“…Intestinal epithelial cell (IEC) shedding is a fundamental response to intestinal damage, yet underlying mechanisms and functions have been difficult to…”
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Endogenous Tagging at the cdh1 Locus for Live Visualization of E-Cadherin Dynamics by Cronan, Mark R, Tobin, David M

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Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity by Strachan, Ryan T, Sciaky, Noah, Cronan, Mark R, Kroeze, Wesley K, Roth, Bryan L

“…The concept of functional selectivity has now thoroughly supplanted the previously entrenched notion of intrinsic efficacy by explaining how agonists and…”
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Defining MAP3Kinases Required for MDA-MB-231 Cell Tumor Growth and Metastasis by Cronan, Mark R., Nakamura, Kazuhiro, Johnson, Nancy L., Granger, Deborah A., Cuevas, Bruce D., Wang, Jian-Guo, Mackman, Nigel, Scott, John E., Dohlman, Henrik G., Johnson, Gary L.

“…Analysis of patient tumors suggests multiple MAP3kinases (MAP3Ks) are critical for growth and metastasis of cancer cells. MAP3Ks selectively control the…”
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