Search Results - "Cromwell, Mary E. M"

Protein aggregation and bioprocessing by Cromwell, Mary E M, Hilario, Eric, Jacobson, Fred

“…Protein aggregation is a common issue encountered during manufacture of biotherapeutics. It is possible to influence the amount of aggregate produced during…”
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Protein Aggregation in Frozen Trehalose Formulations: Effects of Composition, Cooling Rate, and Storage Temperature by Connolly, Brian D, Le, Lan, Patapoff, Thomas W, Cromwell, Mary E M, Moore, Jamie M R, Lam, Philippe

“…This study was designed to assess the effects of cooling rate, storage temperature, and formulation composition on trehalose phase distribution and protein…”
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Kinetics and Thermodynamics of Dimer Formation and Dissociation for a Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor by Moore, Jamie M. R, Patapoff, Thomas W, Cromwell, Mary E. M

“…The recombinant humanized antibody (rhuMAb) VEGF has a high affinity for vascular endothelial growth factor and is currently being evaluated in clinical trials…”
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Benzyl alcohol-induced destabilization of interferon-gamma: a study by hydrogen-deuterium isotope exchange by Tobler, Scott A, Holmes, Bryan W, Cromwell, Mary E M, Fernandez, Erik J

“…The destabilizing effect of a multidose preservative, benzyl alcohol, on IFN-gamma was investigated. Hydrogen-deuterium isotope exchange (HX) detected by mass…”
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The effect of chemical modifications on octanol/water partition (log D) and permeabilities across Caco-2 monolayers by Rubas, Werner, Cromwell, Mary E.M.

“…In the past octanol/water partition coefficients (log D 7.4) have been used extensively to predict intestinal absorption. More recently flux measurements…”
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Synthesis and vibrational analysis of a locked 14-s-cis conformer of retinal by Cromwell, Mary E. M, Gebhard, Ronald, Li, Xiao Yuan, Batenburg, Elvira S, Hopman, Johan C. P, Lugtenburg, Johan, Mathies, Richard A

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Characterization of V3 Loop-Pseudomonas Exotoxin Chimeras by FitzGerald, David J., Fryling, Charlotte M., McKee, Marian L., Vennari, JoAnn C., Wrin, Terri, Cromwell, Mary E.M., Daugherty, Ann L., Mrsny, Randall J.

“…To develop a candidate vaccine for human immunodeficiency virus, type 1 (HIV-1), chimeric proteins were constructed by inserting sequences derived from the V3…”
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Book reviews by A (Bert) G de Boer, Cromwell, Mary E M, Peck, Garnet E, Tyler, Varro E

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