Search Results - "Cromwell, Evan F"

Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity by Sirenko, Oksana, Cromwell, Evan F., Crittenden, Carole, Wignall, Jessica A., Wright, Fred A., Rusyn, Ivan

“…Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes show promise for screening during early drug development. Here, we tested a hypothesis that…”
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High-content assays for characterizing the viability and morphology of 3D cancer spheroid cultures by Sirenko, Oksana, Mitlo, Trisha, Hesley, Jayne, Luke, Steve, Owens, Windsor, Cromwell, Evan F

“…There is an increasing interest in using three-dimensional (3D) spheroids for modeling cancer and tissue biology to accelerate translation research…”
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Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity by Ryan, Kristen R., Sirenko, Oksana, Parham, Fred, Hsieh, Jui-Hua, Cromwell, Evan F., Tice, Raymond R., Behl, Mamta

“…Due to the increasing prevalence of neurological disorders and the large number of untested compounds in the environment, there is a need to develop reliable…”
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High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells by Sirenko, Oksana, Hesley, Jayne, Rusyn, Ivan, Cromwell, Evan F

“…Development of predictive in vitro assays for early toxicity evaluation is extremely important for improving the drug development process and reducing drug…”
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High-content high-throughput assays for characterizing the viability and morphology of human iPSC-derived neuronal cultures by Sirenko, Oksana, Hesley, Jayne, Rusyn, Ivan, Cromwell, Evan F

“…Abstract Development of quantitative high-throughput in vitro assays that enable assessment of viability and morphological changes in neuronal cells is an…”
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Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells by Sirenko, Oksana, Crittenden, Carole, Callamaras, Nick, Hesley, Jayne, Chen, Yen-Wen, Funes, Carlos, Rusyn, Ivan, Anson, Blake, Cromwell, Evan F

“…A large percentage of drugs fail in clinical studies due to cardiac toxicity; thus, development of sensitive in vitro assays that can evaluate potential…”
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Multifunctional profiling of triple-negative breast cancer patient-derived tumoroids for disease modeling by Cromwell, Evan F, Sirenko, Oksana, Nikolov, Ekaterina, Hammer, Matthew, Brock, Courtney K, Matossian, Margarite D, Alzoubi, Madlin S, Collins-Burow, Bridgette M, Burow, Matthew E

“…3D cell models derived from patient tumors are highly translational tools that can recapitulate the complex genetic and molecular compositions of solid cancers…”
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Determination of Hepatotoxicity in iPSC-Derived Hepatocytes by Multiplexed High Content Assays by Sirenko, Oksana, Cromwell, Evan F

“…We present here methods for assessing hepatotoxicity by high content imaging and image analysis. The assays focus on the characterization of toxic effects…”
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A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability by Paulsen, Renee D., Soni, Deena V., Wollman, Roy, Hahn, Angela T., Yee, Muh-Ching, Guan, Anna, Hesley, Jayne A., Miller, Steven C., Cromwell, Evan F., Solow-Cordero, David E., Meyer, Tobias, Cimprich, Karlene A.

“…Signaling pathways that respond to DNA damage are essential for the maintenance of genome stability and are linked to many diseases, including cancer. Here, a…”
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In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model by Sirenko, Oksana, Grimm, Fabian A., Ryan, Kristen R., Iwata, Yasuhiro, Chiu, Weihsueh A., Parham, Frederick, Wignall, Jessica A., Anson, Blake, Cromwell, Evan F., Behl, Mamta, Rusyn, Ivan, Tice, Raymond R.

“…An important target area for addressing data gaps through in vitro screening is the detection of potential cardiotoxicants. Despite the fact that current…”
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Development of a homogeneous high-throughput live-cell G-protein-coupled receptor binding assay by Lee, Paul H, Miller, Steven C, van Staden, Carlo, Cromwell, Evan F

“…The measurement of ligand receptor binding parameters for G-protein-coupled receptors is indispensable in the drug discovery process. Traditional ligand…”
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Semiquantitative Analysis with Laser Ablation Inductively Coupled Plasma Mass Spectrometry by Cromwell, Evan F, Arrowsmith, Peter

“…Techniques for semiquantitative analysis of solid materials by laser ablation sample introduction for inductively coupled plasma mass spectrometry (ICPMS) were…”
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Spinel ferrite Co-γFe2O3 perpendicular media on exchange-coupled underlayers by KOUJIMA, Jun, NAKATA, Kenichi, ANDO, Toshio, SHIMOMAI, Kenichi, DOI, Takanori, SUGIYAMA, Masahiko, CROMWELL, Evan F

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Abstract 4559: Evaluation of the chemotherapy potential to improve the anti-cancer efficacy of PD-L1 inhibition using novel 3D microfluidic co-culture platform by Nikolov, Ekaterina Moroz, Thai, Anthony, Cooper, Lila, Suzuki, Mahomi, Tully, Arvonn, Rajendra, Rashmi, Cromwell, Evan F.

“…Abstract Immunotherapy is now recognized as a powerful therapeutic approach to treat and cure cancer. However, the objective response rates for most solid…”
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Abstract 180: Automation and high content imaging of 3D triple negative breast cancer patient-derived tumoroids assay for compound screening by Sirenko, Oksana, Lim, Angeline, Brock, Courtney K., Nikolov, Katya, Olsen, Cathy, Cromwell, Evan F., Matossian, Margarite D., Burow, Matthew E.

“…Abstract Introduction: Currently there are no clinically approved small molecule targeted therapies for triple negative breast cancer, underlining the critical…”
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Laser Texture and Tribological Study of Alternative Substrates by Jiao, Hong, Jiaa, Chi L., Adam, Johann, Cromwell, Evan F.

“…To achieve the highest recording density commercially available, alternative substrates with an average surface roughness (R a ) of 10-20 Å are generally used…”
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Transition-metal cationization of laser desorbed perfluorinated polyethers with FTICR mass spectrometry by Cromwell, Evan F, Reihs, Karsten, de Vries, Mattanjah S, Ghaderi, Sahba, Wendt, H. Russell, Hunziker, Heinrich E

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Novel multichannel plasma-source mass spectrometer by Cromwell, Evan F., Arrowsmith, Peter

“…A novel mass spectrometer system for elemental analysis is described. The instrument combines an inductively coupled plasma (ICP) ion source with a…”
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