Search Results - "Crompton, M"

Mitochondria and aging: a role for the permeability transition? by Crompton, M.

“…Summary When mitochondria are subjected to oxidative stress and relatively high [Ca2+], they undergo a ‘permeability transition’ in which the inner membrane…”
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Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation by KAMALATI, T, JOLIN, H. E, FRY, M. J, CROMPTON, M. R

“…A high proportion of human breast cancers, in contrast with normal mammary tissue, express the intracellular tyrosine kinase BRK. BRK expression enhances the…”
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Breast tumor kinase (Brk/PTK6) plays a role in the differentiation of primary keratinocytes by Tupper, J., Crompton, M. R., Harvey, A. J.

“…Breast Tumor Kinase (Brk/PTK6) has a relatively limited expression profile in normal tissue. Its expression is restricted to epithelial cells that are…”
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Impact of dissolved oxygen and pH on the removal of selenium from water by iron electrocoagulation by Bae, Yeunook, Crompton, Nyssa M., Sharma, Neha, Yuan, Yihang, Catalano, Jeffrey G., Giammar, Daniel E.

“…•The impacts of dissolved oxygen and pH on selenate removal were tested.•Dissolved Se removal was highest and fastest at pH 8 and strictly anoxic…”
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Meta-Analysis of Therapeutic Hypothermia for Traumatic Brain Injury in Adult and Pediatric Patients by Crompton, Ellie M., Lubomirova, Irina, Cotlarciuc, Ioana, Han, Thang S., Sharma, Sapna D., Sharma, Pankaj

“…OBJECTIVE:Therapeutic hypothermia has been used to attenuate the effects of traumatic brain injuries. However, the required degree of hypothermia, length of…”
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PIN3 Health Outcomes With Daptomycin (DAP) in the Treatment of Methicillin Resistant Staphylococcus Aureus Bacteremia (MRSA-B) With Vancomycin (VAN) Minimum Inhibitory Concentration (MIC) = 2 μG/Ml by Forrest, G, Larson, K, Crompton, M, Patel, H, Boening, A.J

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Ultrafast Proton Transfer Dynamics of Hydroxystilbene Photoacids by Lewis, Frederick D, Sinks, Louise E, Weigel, Wilfried, Sajimon, Meledathu C, Crompton, Elizabeth M

“…The effects of 4-cyano and 3-cyano substituents on the spectroscopic properties and photoacidity of 3- and 4-hydroxystilbene have been investigated. In…”
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p53 mutations in BRCA1-associated familial breast cancer by Crook, T, Crossland, S, Crompton, M R, Osin, P, Gusterson, B A

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Alosetron relieves pain and improves bowel function compared with mebeverine in female nonconstipated irritable bowel syndrome patients by JONES, R. H, HOLTMANN, G, RODRIGO, L, EHSANULLAH, R. S. B, CROMPTON, P. M, JACQUES, L. A, MILLS, J. G

“…Background : Irritable bowel syndrome is one of the most common gastrointestinal disorders, yet no therapy convincingly controls the multiple symptoms of this…”
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SB4 Propensity-Score Matching (PSM) to Control for Selection Bias in “Real-World” Treatment Comparisons: A Cautionary Tale Concerning Antibiotic Therapy for Infectious Disease by Berger, A, Mckinnon, P.S, Larson, K, Crompton, M, Hennegan, K, Weber, D.J, Boening, A.J, Oster, G

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p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours by CROOK, T, BROOKS, L. A, PARKER, G, ALLDAY, M. J, CROMPTON, M. R, GUSTERSON, B. A, CROSSLAND, S, OSIN, P, BARKER, K. T, WALLER, J, PHILP, E, SMITH, P. D, YULUG, I, PETO, J

“…The status of p53 was investigated in breast tumours arising in germ-line carriers of mutant alleles of BRCA1 and BRCA2 and in a control series of sporadic…”
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A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK by MITCHELL, Philip J, SARA, Elizabeth A, CROMPTON, Mark R

“…The brk gene encodes a non-receptor tyrosine kinase that has been found to be overexpressed in approximately two thirds of breast tumours. Using a yeast…”
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On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury by Duchen, M R, McGuinness, O, Brown, L A, Crompton, M

“…Mammalian cardiomyocytes may withstand prolonged periods of ischaemia, only to die on reperfusion. We review data that implicate mitochondrial dysfunction as a…”
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Measuring the influence of business coaching on fast-growth firms by Crompton, Bernadette M., Smyrnios, Kosmas X., Bi, Rui

“…Small-to-medium firms on a fast-growth trajectory experience a variety of pressures from both internal and external sources. The effect business coaching has…”
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Regulation of Tiam1 Nucleotide Exchange Activity by Pleckstrin Domain Binding Ligands by Crompton, Anne M., Foley, Louise H., Wood, Alexander, Roscoe, William, Stokoe, David, McCormick, Frank, Symons, Marc, Bollag, Gideon

“…Rho family GTPases play roles in cytoskeletal organization and cellular transformation. Tiam1 is a member of the Dbl family of guanine nucleotide exchange…”
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Hydroxystilbene Isomer-Specific Photoisomerization versus Proton Transfer by Lewis, Frederick D, Crompton, Elizabeth M

“…The ground- and excited-state acidities of 3- and 4-hydroxystilbene have been investigated in aqueous solution. Approximate pK a* values determined from the…”
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Cytotoxic response of ovarian cancer cell lines to IFN-γ is associated with sustained induction of IRF-1 and p21 mRNA by BURKE, F, SMITH, P. D, CROMPTON, M. R, UPTON, C, BALKWILL, F. R

“…Interferon-gamma (IFN-gamma) has some anti-tumour activity in human ovarian cancer. This cytokine inhibited proliferation in three of four ovarian cancer cell…”
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Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions by SMITH, P. D, CROSSLAND, S, CROOK, T, PARKER, G, OSIN, P, BROOKS, L, WALLER, J, PHILP, E, CROMPTON, M. R, GUSTERSON, B. A, ALLDAY, M. J

“…Inheritance of germ-line mutant alleles of BRCA1 and BRCA2 confers a markedly increased risk of breast cancer and we have previously reported a higher…”
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Nuclear location and cell cycle regulation of the BRCA2 protein by BERTWISTLE, D, SWIFT, S, MARSTON, N. J, JACKSON, L. E, CROSSLAND, S, CROMPTON, M. R, MARSHALL, C. J, ASHWORTH, A

“…Women carrying a germ-line mutation in the BRCA1 or BRCA2 genes have a high risk of developing breast cancer, and loss of the wild-type allele in tumors…”
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Ras-related TC21 is activated by mutation in a breast cancer cell line, but infrequently in breast carcinomas in vivo by BARKER, K. T, CROMPTON, M. R

“…Activating ras mutations are found in many types of human tumour. Mutations in Harvey (H-), Kirsten (K-) and neuronal (N-) ras are, however, rarely found in…”
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