Search Results - "Crofts, Terence S"

Next-generation approaches to understand and combat the antibiotic resistome by Crofts, Terence S., Gasparrini, Andrew J., Dantas, Gautam

“…Key Points The anthropogenic use of antibiotics has selected for an increase in the evolution and dissemination of antibiotic resistance in environmental and…”
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Antibiotics and the developing infant gut microbiota and resistome by Gibson, Molly K, Crofts, Terence S, Dantas, Gautam

“…Highlights • Neonatal and pediatric populations routinely receive antibiotic treatment. • Disrupting the developing infant gut microbiota may have long-term…”
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Identification of specific corrinoids reveals corrinoid modification in dechlorinating microbial communities by Men, Yujie, Seth, Erica C, Yi, Shan, Crofts, Terence S, Allen, Robert H, Taga, Michiko E, Alvarez‐Cohen, Lisa

“…Cobalamin and other corrinoids are essential cofactors for many organisms. The majority of microbes with corrinoid‐dependent enzymes do not produce corrinoids…”
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Functional and Structural Characterization of Diverse NfsB Chloramphenicol Reductase Enzymes from Human Pathogens by Mullowney, Michael W, Maltseva, Natalia I, Endres, Michael, Kim, Youngchang, Joachimiak, Andrzej, Crofts, Terence S

“…Phylogenetically diverse bacteria can carry out chloramphenicol reduction, but only a single enzyme has been described that efficiently catalyzes this…”
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Mosaic Ends Tagmentation (METa) Assembly for Highly Efficient Construction of Functional Metagenomic Libraries by Crofts, Terence S, McFarland, Alexander G, Hartmann, Erica M

“…Functional metagenomic libraries, physical bacterial libraries which allow the high-throughput capture and expression of microbiome genes, have been…”
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A bioassay for the detection of benzimidazoles reveals their presence in a range of environmental samples by Crofts, Terence S, Men, Yujie, Alvarez-Cohen, Lisa, Taga, Michiko E

“…Cobamides are a family of enzyme cofactors that include vitamin B12 (cobalamin) and are produced solely by prokaryotes. Structural variability in the lower…”
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Discovery and Characterization of a Nitroreductase Capable of Conferring Bacterial Resistance to Chloramphenicol by Crofts, Terence S, Sontha, Pratyush, King, Amber O, Wang, Bin, Biddy, Brent A, Zanolli, Nicole, Gaumnitz, John, Dantas, Gautam

“…Widespread antibiotic resistance has led to the reappraisal of abandoned antibiotics including chloramphenicol. However, enzyme(s) underlying one form of…”
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History of the streptothricin antibiotics and evidence for the neglect of the streptothricin resistome by Franck, Ezabelle, Crofts, Terence S.

“…Abstract The streptothricin antibiotics were among the first antibiotics to be discovered from the environment and remain some of the most recovered…”
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Shared strategies for β-lactam catabolism in the soil microbiome by Crofts, Terence S., Wang, Bin, Spivak, Aaron, Gianoulis, Tara A., Forsberg, Kevin J., Gibson, Molly K., Johnsky, Lauren A., Broomall, Stacey M., Rosenzweig, C. Nicole, Skowronski, Evan W., Gibbons, Henry S., Sommer, Morten O. A, Dantas, Gautam

“…The soil microbiome can produce, resist, or degrade antibiotics and even catabolize them. While resistance genes are widely distributed in the soil, there is a…”
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Checkpoint Checkmate: Microbiota Modulation of Cancer Immunotherapy by Keen, Eric C, Crofts, Terence S, Dantas, Gautam

“…In recent years, immune checkpoint inhibitors (ICIs)5, which block the ability of cancer cells to evade killing by CD8 + T cells, have begun to revolutionize…”
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Antibiotic perturbation of the preterm infant gut microbiome and resistome by Gasparrini, Andrew J., Crofts, Terence S., Gibson, Molly K., Tarr, Phillip I., Warner, Barbara B., Dantas, Gautam

“…The gut microbiota plays important roles in nutrient absorption, immune system development, and pathogen colonization resistance. Perturbations early in life…”
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Publisher Correction: Shared strategies for β-lactam catabolism in the soil microbiome by Crofts, Terence S., Wang, Bin, Spivak, Aaron, Gianoulis, Tara A., Forsberg, Kevin J., Gibson, Molly K., Johnsky, Lauren A., Broomall, Stacey M., Rosenzweig, C. Nicole, Skowronski, Evan W., Gibbons, Henry S., Sommer, Morten O. A, Dantas, Gautam

“…In the version of the article originally published, the x axis of the graph in Fig. 4d was incorrectly labeled as “Retention time (min)”. It should read…”
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Regiospecific Formation of Cobamide Isomers Is Directed by CobT by Crofts, Terence S, Hazra, Amrita B, Tran, Jennifer LA, Sokolovskaya, Olga M, Osadchiy, Vadim, Ad, Omer, Pelton, Jeffrey, Bauer, Stefan, Taga, Michiko E

“…Cobamides, which include vitamin B12 (cobalamin), are a class of modified tetrapyrroles synthesized exclusively by prokaryotes that function as cofactors for…”
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Cobamide Structure Depends on Both Lower Ligand Availability and CobT Substrate Specificity by Crofts, Terence S., Seth, Erica C., Hazra, Amrita B., Taga, Michiko E.

“…Cobamides are members of the vitamin B12 family of cofactors that function in a variety of metabolic processes and are synthesized only by prokaryotes…”
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Engineering the binding properties of the T cell receptor:peptide:MHC ternary complex that governs T cell activity by Bowerman, Natalie A., Crofts, Terence S., Chlewicki, Lukasz, Do, Priscilla, Baker, Brian M., Christopher Garcia, K., Kranz, David M.

“…The potency of a T cell is determined in large part by two interactions, binding of a cognate peptide to the MHC, and binding of the T cell receptor (TCR) to…”
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Draft Genome Sequences of Three β-Lactam-Catabolizing Soil Proteobacteria by Crofts, Terence S, Wang, Bin, Spivak, Aaron, Gianoulis, Tara A, Forsberg, Kevin J, Gibson, Molly K, Johnsky, Lauren A, Broomall, Stacey M, Rosenzweig, C Nicole, Skowronski, Evan W, Gibbons, Henry S, Sommer, Morten O A, Dantas, Gautam

“…Most antibiotics are derived from the soil, but their catabolism there, which is necessary to close the antibiotic carbon cycle, remains uncharacterized. We…”
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Analysis of Substrate Specificity in CobT Homologs Reveals Widespread Preference for DMB, the Lower Axial Ligand of Vitamin B12 by Hazra, Amrita B., Tran, Jennifer L.A., Crofts, Terence S., Taga, Michiko E.

“…Cobamides such as vitamin B12 (cobalamin) are produced exclusively by prokaryotes and used by many other organisms as cofactors for diverse metabolic…”
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Analysis of substrate specificity in CobT homologs reveals widespread preference for DMB, the lower axial ligand of vitamin B(12) by Hazra, Amrita B, Tran, Jennifer L A, Crofts, Terence S, Taga, Michiko E

“…Cobamides such as vitamin B12 (cobalamin) are produced exclusively by prokaryotes and used by many other organisms as cofactors for diverse metabolic…”
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