Search Results - "Croci, O"

Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer by Rabinovich, Gabriel A., Croci, Diego O.

“…Numerous regulatory programs have been identified that contribute to the restoration of homeostasis at the conclusion of immune responses and to safeguarding…”
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Galectin-1 Deactivates Classically Activated Microglia and Protects from Inflammation-Induced Neurodegeneration by Starossom, Sarah C., Mascanfroni, Ivan D., Imitola, Jaime, Cao, Li, Raddassi, Khadir, Hernandez, Silvia F., Bassil, Ribal, Croci, Diego O., Cerliani, Juan P., Delacour, Delphine, Wang, Yue, Elyaman, Wassim, Khoury, Samia J., Rabinovich, Gabriel A.

“…Inflammation-mediated neurodegeneration occurs in the acute and the chronic phases of multiple sclerosis (MS) and its animal model, experimental autoimmune…”
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Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors by Croci, Diego O., Cerliani, Juan P., Dalotto-Moreno, Tomas, Méndez-Huergo, Santiago P., Mascanfroni, Ivan D., Dergan-Dylon, Sebastián, Toscano, Marta A., Caramelo, Julio J., García-Vallejo, Juan J., Ouyang, Jing, Mesri, Enrique A., Junttila, Melissa R., Bais, Carlos, Shipp, Margaret A., Salatino, Mariana, Rabinovich, Gabriel A.

“…The clinical benefit conferred by vascular endothelial growth factors (VEGF)-targeted therapies is variable, and tumors from treated patients eventually…”
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Targeting Galectin-1 Overcomes Breast Cancer-Associated Immunosuppression and Prevents Metastatic Disease by DALOTTO-MORENO, Tomás, CROCI, Diego O, SUNDBLAD, Victoria, RABINOVICH, Gabriel A, SALATINO, Mariana, CERLIANI, Juan P, MARTINEZ-ALLO, Veronica C, DERGAN-DYLON, Sebastián, MENDEZ-HUERGO, Santiago P, STUPIRSKI, Juan C, MAZAL, Daniel, OSINAGA, Eduardo, TOSCANO, Marta A

“…Galectin-1 (Gal1), an evolutionarily conserved glycan-binding protein, contributes to the creation of an immunosuppressed microenvironment at sites of tumor…”
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Compensatory RNA polymerase 2 loading determines the efficacy and transcriptional selectivity of JQ1 in Myc-driven tumors by Donato, E, Croci, O, Sabò, A, Muller, H, Morelli, M J, Pelizzola, M, Campaner, S

“…Inhibition of bromodomain and extraterminal motif (BET) proteins such as BRD4 bears great promise for cancer treatment and its efficacy has been frequently…”
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Galectins: Multitask signaling molecules linking fibroblast, endothelial and immune cell programs in the tumor microenvironment by Elola, María T., Ferragut, Fátima, Méndez-Huergo, Santiago P., Croci, Diego O., Bracalente, Candelaria, Rabinovich, Gabriel A.

“…•Galectins influence tumor progression by reprogramming the tumor microenvironment.•Galectins are expressed and released by both tumoral and non-tumoral…”
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Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells by Bannoud, Nadia, Dalotto-Moreno, Tomás, Kindgard, Lucía, García, Pablo A, Blidner, Ada G, Mariño, Karina V, Rabinovich, Gabriel A, Croci, Diego O

“…Hypoxia, angiogenesis, and immunosuppression have been proposed to be interrelated events that fuel tumor progression and impair the clinical effectiveness of…”
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Galectins as potential therapeutic targets in STIs in the female genital tract by Lujan, Agustin L., Croci, Diego O., Rabinovich, Gabriel A., Damiani, Maria T.

“…Every day, more than one million people worldwide acquire a sexually transmitted infection (STI). This public health problem has a direct effect on women’s…”
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Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death by Toscano, Marta A, Bianco, Germán A, Ilarregui, Juan M, Croci, Diego O, Correale, Jorge, Hernandez, Joseph D, Zwirner, Norberto W, Poirier, Francoise, Riley, Eleanor M, Baum, Linda G, Rabinovich, Gabriel A

“…Regulated glycosylation controls T cell processes, including activation, differentiation and homing by creating or masking ligands for endogenous lectins. Here…”
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Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment by Croci, Diego O, Cerliani, Juan P, Pinto, Nicolas A, Morosi, Luciano G, Rabinovich, Gabriel A

“…Abnormal glycosylation is a typical hallmark of the transition from healthy to neoplastic tissues. Although the importance of glycans and glycan-binding…”
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A Unique Galectin Signature in Human Prostate Cancer Progression Suggests Galectin-1 as a Key Target for Treatment of Advanced Disease by LADERACH, Diego J, GENTILINI, Lucas D, SHIPP, Margaret A, VAZQUEZ, Elba, CHAUCHEREAU, Anne, KUTOK, Jeffery L, RODIG, Scott J, ELOLA, MariaT, COMPAGNO, Daniel, RABINOVICH, Gabriel A, GIRIBALDI, Laura, CARDENAS DELGADO, Victor, NUGNES, Lorena, CROCI, Diego O, AL NAKOUZI, Nader, SACCA, Paula, CASAS, Gabriel, MAZZA, Osvaldo

“…Galectins, a family of glycan-binding proteins, influence tumor progression by modulating interactions between tumor, endothelial, stromal, and immune cells…”
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Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression by Rossi, Lucas E., Avila, Damián E., Spallanzani, Raúl G., Ziblat, Andrea, Fuertes, Mercedes B., Lapyckyj, Lara, Croci, Diego O., Rabinovich, Gabriel A., Domaica, Carolina I., Zwirner, Norberto W.

“…Histone deacetylase inhibitors (HDACi) severely impair NK cell‐mediated functions, which has translational consequences as HDACi could weaken immune…”
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Galectins as Emerging Glyco-Checkpoints and Therapeutic Targets in Glioblastoma by Videla-Richardson, Guillermo A, Morris-Hanon, Olivia, Torres, Nicolás I, Esquivel, Myrian I, Vera, Mariana B, Ripari, Luisina B, Croci, Diego O, Sevlever, Gustavo E, Rabinovich, Gabriel A

“…Despite recent advances in diagnosis and treatment, glioblastoma (GBM) represents the most common and aggressive brain tumor in the adult population, urging…”
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Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs by Pinto, Nicolás A., Abba, Martín C., Laporte, Lorena, Pérez Sáez, Juan M., Blidner, Ada G., Torres, Nicolás I., Morales, Rosa M., Gatto, Sabrina G., Bach, Camila A., Veigas, Florencia, García Rivello, Hernán J., Song, Peng, Frederiksen, Jane H., Rasmussen, Lene Juel, Poirier, Francoise, Croci, Diego O., Sundblad, Victoria, Rabinovich, Gabriel A., Cerliani, Juan P.

“…Non-melanoma skin cancer (NMSC) has risen dramatically as a result of chronic exposure to sunlight ultraviolet (UV) radiation, climatic changes and clinical…”
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Tumor immune escape mechanisms that operate during metastasis by Croci, D O, Salatino, M

“…Immune cells actively influence, among other factors, each step of tumor development determining the chance of a cancer cell to survive in a threaten…”
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Dynamic cross-talk between tumor and immune cells in orchestrating the immunosuppressive network at the tumor microenvironment by Croci, Diego O, Zacarías Fluck, Mariano F, Rico, María J, Matar, Pablo, Rabinovich, Gabriel A, Scharovsky, O Graciela

“…Accumulating evidence indicates that a dynamic cross-talk between tumors and the immune system can regulate tumor growth and metastasis. Increased…”
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Modulation of endothelial cell migration and angiogenesis: a novel function for the “tandem‐repeat” lectin galectin‐8 by Delgado, Víctor M. Cárdenas, Nugnes, Lorena G., Colombo, Lucas L., Troncoso, María F., Fernández, Marisa M., Malchiodi, Emilio L., Frahm, Isabel, Croci, Diego O., Compagno, Daniel, Rabinovich, Gabriel A., Wolfenstein‐Todel, Carlota, Elola, María T.

“…Angiogenesis, the growth of new capillaries from preexisting blood vessels, is a complex process involving endothelial cell (EC) activation, disruption of…”
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Expression and function of cathelicidin hCAP18/LL-37 in chronic lymphocytic leukemia by Podaza, Enrique, Palacios, Florencia, Croci, Diego O, Risnik, Denise, Yan, Xiao J, Almejún, María Belén, Colado, Ana, Elías, Esteban E, Borge, Mercedes, Morande, Pablo E, Bezares, Raimundo, Fernández-Grecco, Horacio, Rabinovich, Gabriel A, Gamberale, Romina, Chiorazzi, Nicholas, Giordano, Mirta

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Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet by Hockl, Pablo F., Wolosiuk, Alejandro, Pérez-Sáez, Juan M., Bordoni, Andrea V., Croci, Diego O., Toum-Terrones, Yamili, Soler-Illia, Galo J.A.A., Rabinovich, Gabriel A.

“…[Display omitted] Recent efforts toward defining the molecular features of the tumor microenvironment have revealed dramatic changes in the expression of…”
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Extracellular vesicles from human plasma dampen inflammation and promote tissue repair functions in macrophages by Adamczyk, Alan M., Leicaj, María Luz, Fabiano, Martina Paula, Cabrerizo, Gonzalo, Bannoud, Nadia, Croci, Diego O., Witwer, Kenneth W., Remes Lenicov, Federico, Ostrowski, Matías, Pérez, Paula Soledad

“…Although inflammation is a vital defence response to infection, if left uncontrolled, it can lead to pathology. Macrophages are critical players both in…”
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