Search Results - "Crochemore, Clément"
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CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence
Published in Nature communications (06-12-2019)“…Cellular senescence has causative links with ageing and age-related diseases, however, it remains unclear if progeroid factors cause senescence in normal…”
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A novel paradigm links mitochondrial dysfunction with muscle stem cell impairment in sepsis
Published in Biochimica et biophysica acta. Molecular basis of disease (01-10-2017)“…Sepsis is an acute systemic inflammatory response of the body to microbial infection and a life threatening condition associated with multiple organ failure…”
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An integrated functional and transcriptomic analysis reveals that repeated exposure to diesel exhaust induces sustained mitochondrial and cardiac dysfunctions
Published in Environmental pollution (1987) (01-03-2019)“…Diesel exhaust (DE) contributes to air pollution, an important risk factor for cardiovascular diseases. However, the mechanisms by which DE exposure induces…”
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Nitrogen Dioxide Inhalation Exposures Induce Cardiac Mitochondrial Reactive Oxygen Species Production, Impair Mitochondrial Function and Promote Coronary Endothelial Dysfunction
Published in International journal of environmental research and public health (30-07-2020)“…Traffic air pollution is a major health problem and is recognized as an important risk factor for cardiovascular (CV) diseases. In a previous experimental…”
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Precision cut lung slices as an efficient tool for in vitro lung physio-pharmacotoxicology studies
Published in Xenobiotica (01-01-2013)“…1. We review the specific approaches for lung tissue slices preparation and incubation systems and the research application fields in which lung slices proved…”
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Mineralocorticoid receptor blockade with finerenone improves heart function and exercise capacity in ovariectomized mice
Published in ESC Heart Failure (01-06-2021)“…Aims In post‐menopausal women, incidence of heart failure with preserved ejection fraction is higher than in men. Hormonal replacement therapies did not…”
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Epigenomic signature of accelerated ageing in progeroid Cockayne syndrome
Published in Aging cell (01-10-2023)“…Abstract Cockayne syndrome (CS) and UV‐sensitive syndrome (UVSS) are rare genetic disorders caused by mutation of the DNA repair and multifunctional CSA or CSB…”
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Identification and Characterization of a Novel Recurrent ERCC6 Variant in Patients with a Severe Form of Cockayne Syndrome B
Published in Genes (29-11-2021)“…Cockayne syndrome (CS) is a rare disease caused by mutations in / or / . We report here the clinical, genetic, and functional analyses of three unrelated…”
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Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy
Published in Nature communications (15-12-2015)“…Sepsis, or systemic inflammatory response syndrome, is the major cause of critical illness resulting in admission to intensive care units. Sepsis is caused by…”
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