Search Results - "Croce, CM"

Targeting microRNAs in cancer: rationale, strategies and challenges by Garzon, Ramiro, Croce, Carlo M, Marcucci, Guido

“…Key Points The rationale for using microRNAs (miRNAs) as anticancer drugs is based on two major findings: miRNA expression is deregulated in cancer compared…”
Get full text

Circulating Micrornas Predict Survival of Patients with Tumors of Glial Origin by Drusco, Alessandra, Fadda, Paolo, Nigita, Giovanni, Fassan, Matteo, Bottoni, Arianna, Gardiman, Marina P, Sacchi, Diana, Calore, Federica, Carosi, Mariantonia, Antenucci, Anna, Casini, Beatrice, Kelani, Hesham, Pescarmona, Edoardo, Di Leva, Gianpiero, Zanesi, Nicola, Berger, Mitchell S, Croce, Carlo M

“…The World Health Organization has recently introduced molecular prognostic-diagnostic biomarkers in the classification of Central Nervous System (CNS) tumors…”
Get full text

miRNAs, Cancer, and Stem Cell Division by Croce, Carlo M., Calin, George A.

“…MicroRNAs (miRNAs) are known to regulate the expression of genes involved in the control of development, proliferation, apoptosis, and the stress response. As…”
Get full text

Abstract P6-05-07: The effects of microRNA modulation of polo-like kinase 1 in breast cancer cell lines by Zalles, N, Gasparini, P, Croce, CM

“…Abstract BACKGROUND: Elucidating a more universal therapeutic target is key to effectively combat the heterogeneity of breast cancer (BrCa). MicroRNAs (miRs)…”
Get full text

microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer by Braconi, C, Kogure, T, Valeri, N, Huang, N, Nuovo, G, Costinean, S, Negrini, M, Miotto, E, Croce, C M, Patel, T

“…The human genome is replete with long non-coding RNAs (lncRNA), many of which are transcribed and likely to have a functional role. Microarray analysis of >23…”
Get full text

Oral Contraceptive-induced Expression of Prostate-specific Antigen in the Female Breast by Yu, H, Diamandis, E P, Monne, M, Croce, C M

“…Prostate-specific antigen (PSA) is widely used as a tumor marker of prostatic adenocarcinoma. We recently found that 30% of breast tumors produce PSA and that…”
Get full text

Unique microRNA molecular profiles in lung cancer diagnosis and prognosis by Yanaihara, Nozomu, Caplen, Natasha, Bowman, Elise, Seike, Masahiro, Kumamoto, Kensuke, Yi, Ming, Stephens, Robert M., Okamoto, Aikou, Yokota, Jun, Tanaka, Tadao, Calin, George Adrian, Liu, Chang-Gong, Croce, Carlo M., Harris, Curtis C.

“…MicroRNA (miRNA) expression profiles for lung cancers were examined to investigate miRNA's involvement in lung carcinogenesis. miRNA microarray analysis…”
Get full text

Pre-B Cell Proliferation and Lymphoblastic Leukemia/High-Grade Lymphoma in Eμ-miR155 Transgenic Mice by Costinean, Stefan, Zanesi, Nicola, Pekarsky, Yuri, Tili, Esmerina, Volinia, Stefano, Heerema, Nyla, Croce, Carlo M.

“…MicroRNAs (miRNAs) represent a newly discovered class of posttranscriptional regulatory noncoding small RNAs that bind to targeted mRNAs and either block their…”
Get full text

MicroRNA-221 222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways by Rao, X, Di Leva, G, Li, M, Fang, F, Devlin, C, Hartman-Frey, C, Burow, M E, Ivan, M, Croce, C M, Nephew, K P

“…Fulvestrant is a selective estrogen receptor downregulator (SERD) and highly effective antagonist to hormone-sensitive breast cancers following failure of…”
Get full text

miR-221 222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPμ by Quintavalle, C, Garofalo, M, Zanca, C, Romano, G, Iaboni, M, del Basso De Caro, M, Martinez-Montero, J C, Incoronato, M, Nuovo, G, Croce, C M, Condorelli, G

“…Glioblastoma is the most frequent brain tumor in adults and is the most lethal form of human cancer. Despite the improvements in treatments, survival of…”
Get full text

A MicroRNA Expression Signature of Human Solid Tumors Defines Cancer Gene Targets by Volinia, Stefano, Calin, George A., Liu, Chang-Gong, Ambs, Stefan, Cimmino, Amelia, Petrocca, Fabio, Visone, Rosa, Iorio, Marilena, Roldo, Claudia, Ferracin, Manuela, Prueitt, Robyn L., Yanaihara, Nozumu, Lanza, Giovanni, Scarpa, Aldo, Vecchione, Andrea, Negrini, Massimo, Harris, Curtis C., Croce, Carlo M.

“…Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression and are differentially expressed in normal tissues and cancers. From a…”
Get full text

Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine by Blum, William, Garzon, Ramiro, Klisovic, Rebecca B, Schwind, Sebastian, Walker, Alison, Geyer, Susan, Liu, Shujun, Havelange, Violaine, Becker, Heiko, Schaaf, Larry, Mickle, Jon, Devine, Hollie, Kefauver, Cheryl, Devine, Steven M, Chan, Kenneth K, Heerema, Nyla A, Bloomfield, Clara D, Grever, Michael R, Byrd, John C, Villalona-Calero, Miguel, Croce, Carlo M, Marcucci, Guido

“…A phase II clinical trial with single-agent decitabine was conducted in older patients (≥60 years) with previously untreated acute myeloid leukemia (AML) who…”
Get full text

The Role of MicroRNA Genes in Papillary Thyroid Carcinoma by He, Huiling, Krystian Jazdzewski, Li, Wei, Liyanarachchi, Sandya, Rebecca Nagy, Volinia, Stefano, Calin, George A., Liu, Chang-gong, Kaarle Franssila, Suster, Saul, Kloos, Richard T., Croce, Carlo M., de la Chapelle, Albert

“…Apart from alterations in the RET/PTC-RAS-BRAF pathway, comparatively little is known about the genetics of papillary thyroid carcinoma (PTC). We show that…”
Get full text

miR-15 and miR-16 Induce Apoptosis by Targeting BCL2 by Cimmino, Amelia, Calin, George Adrian, Fabbri, Muller, Iorio, Marilena V., Ferracin, Manuela, Shimizu, Masayoshi, Wojcik, Sylwia E., Aqeilan, Rami I., Zupo, Simona, Dono, Mariella, Rassenti, Laura, Alder, Hansjuerg, Volinia, Stefano, Liu, Chang-gong, Kipps, Thomas J., Negrini, Massimo, Croce, Carlo M.

“…Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the…”
Get full text

MicroRNA gene expression deregulation in human breast cancer by IORIO, Marilena V, FERRACIN, Manuela, MENARD, Sylvie, PALAZZO, Juan P, ROSENBERG, Anne, MUSIANI, Piero, VOLINIA, Stefano, NENCI, Italo, COLIN, George A, QUERZOLI, Patrizia, NEGRINI, Massimo, CROCE, Carlo M, LIU, Chang-Gong, VERONESE, Angelo, SPIZZO, Riccardo, SABBIONI, Silvia, MAGRI, Eros, PEDRIALI, Massimo, FABBRI, Muller, CAMPIGLIO, Manuela

“…MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA…”
Get full text

A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia by Calin, George Adrian, Ferracin, Manuela, Cimmino, Amelia, Di Leva, Gianpiero, Shimizu, Masayoshi, Wojcik, Sylwia E, Iorio, Marilena V, Visone, Rosa, Sever, Nurettin Ilfer, Fabbri, Muller, Iuliano, Rodolfo, Palumbo, Tiziana, Pichiorri, Flavia, Roldo, Claudia, Garzon, Ramiro, Sevignani, Cinzia, Rassenti, Laura, Alder, Hansjuerg, Volinia, Stefano, Liu, Chang-gong, Kipps, Thomas J, Negrini, Massimo, Croce, Carlo M

“…A microRNA signature consisting of 13 genes was associated with factors that predict disease progression in patients with chronic lymphocytic leukemia. A…”
Get full text

Loss of miR-125b-1 contributes to head and neck cancer development by dysregulating TACSTD2 and MAPK pathway by Nakanishi, H, Taccioli, C, Palatini, J, Fernandez-Cymering, C, Cui, R, Kim, T, Volinia, S, Croce, C M

“…MicroRNAs (miRNAs) have important roles in the initiation and progression of human cancer, but their role in head and neck cancer development and progression…”
Get full text

Extensive modulation of a set of microRNAs in primary glioblastoma by Ciafrè, S.A., Galardi, S., Mangiola, A., Ferracin, M., Liu, C.-G., Sabatino, G., Negrini, M., Maira, G., Croce, C.M., Farace, M.G.

“…MicroRNAs (miRNAs) are short non-coding RNA molecules playing regulatory roles in animals and plants by repressing translation or cleaving RNA transcripts. The…”
Get full text

Molecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to NF-kB pathway inhibition by Sapienza, M R, Fuligni, F, Agostinelli, C, Tripodo, C, Righi, S, Laginestra, M A, Pileri, A, Mancini, M, Rossi, M, Ricci, F, Gazzola, A, Melle, F, Mannu, C, Ulbar, F, Arpinati, M, Paulli, M, Maeda, T, Gibellini, D, Pagano, L, Pimpinelli, N, Santucci, M, Cerroni, L, Croce, C M, Facchetti, F, Piccaluga, P P, Pileri, S A

“…Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare disease of controversial origin recently recognized as a neoplasm deriving from plasmacytoid…”
Get full text

Human MicroRNA Genes Are Frequently Located at Fragile Sites and Genomic Regions Involved in Cancers by Calin, George Adrian, Sevignani, Cinzia, Dumitru, Calin Dan, Hyslop, Terry, Noch, Evan, Yendamuri, Sai, Shimizu, Masayoshi, Rattan, Sashi, Bullrich, Florencia, Negrini, Massimo, Croce, Carlo M.

“…A large number of tiny noncoding RNAs have been cloned and named microRNAs (miRs). Recently, we have reported that miR-15a and miR-16a, located at 13q14, are…”
Get full text