Search Results - "Crivelli, Simone M."

Exploring the role of mitochondrial uncoupling protein 4 in brain metabolism: implications for Alzheimer's disease by Crivelli, Simone M, Gaifullina, Aisylu, Chatton, Jean-Yves

“…The brain's high demand for energy necessitates tightly regulated metabolic pathways to sustain physiological activity. Glucose, the primary energy substrate,…”
Get full text

Palmitoylation of acetylated tubulin and association with ceramide-rich platforms is critical for ciliogenesis by Tripathi, Priyanka, Zhu, Zhihui, Qin, Haiyan, Elsherbini, Ahmed, Crivelli, Simone M., Roush, Emily, Wang, Guanghu, Spassieva, Stefka D., Bieberich, Erhard

“…Microtubules are polymers composed of αβ-tubulin subunits that provide structure to cells and play a crucial role in in the development and function of…”
Get full text

Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles by Crivelli, Simone M., Giovagnoni, Caterina, Zhu, Zhihui, Tripathi, Priyanka, Elsherbini, Ahmed, Quadri, Zainuddin, Pu, Jian, Zhang, Liping, Ferko, Branislav, Berkes, Dusan, Spassieva, Stefka D., Martinez‐Martinez, Pilar, Bieberich, Erhard

“…The formation of extracellular vesicles (EVs) is induced by the sphingolipid ceramide. How this pathway is regulated is not entirely understood. Here, we…”
Get full text

Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity by Elsherbini, Ahmed, Kirov, Alexander S, Dinkins, Michael B, Wang, Guanghu, Qin, Haiyan, Zhu, Zhihui, Tripathi, Priyanka, Crivelli, Simone M, Bieberich, Erhard

“…Amyloid-β (Aβ) associates with extracellular vesicles termed exosomes. It is not clear whether and how exosomes modulate Aβ neurotoxicity in Alzheimer's…”
Get full text

Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer's disease pathology in the 5xFAD mouse by Crivelli, Simone M, Quadri, Zainuddin, Vekaria, Hemendra J, Zhu, Zhihui, Tripathi, Priyanka, Elsherbini, Ahmed, Zhang, Liping, Sullivan, Patrick G, Bieberich, Erhard

“…In Alzheimer's disease (AD), reactive astrocytes produce extracellular vesicles (EVs) that affect mitochondria in neurons. Here, we show that Aβ-induced…”
Get full text

In vivo evidence of exosome-mediated Aβ neurotoxicity by Elsherbini, Ahmed, Qin, Haiyan, Zhu, Zhihui, Tripathi, Priyanka, Crivelli, Simone M., Bieberich, Erhard

“…In our recent publication [2], we showed that serum from the transgenic mouse model of familial AD (5xFAD) and AD patients as well as 5xFAD brain-derived…”
Get full text

FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer’s disease expressing APOE4 by Crivelli, Simone M., Luo, Qian, Kruining, Daan van, Giovagnoni, Caterina, Mané-Damas, Marina, den Hoedt, Sandra, Berkes, Dusan, De Vries, Helga E., Mulder, Monique T., Walter, Jochen, Waelkens, Etienne, Derua, Rita, Swinnen, Johannes V., Dehairs, Jonas, Wijnands, Erwin P.M., Bieberich, Erhard, Losen, Mario, Martinez-Martinez, Pilar

“…The protection mediated by the bioactive sphingolipid sphingosine-1-phosphate (S1P) declines during Alzheimer’s disease (AD) progression, especially in…”
Get full text

Ceramide analog [18F]F-HPA-12 detects sphingolipid disbalance in the brain of Alzheimer’s disease transgenic mice by functioning as a metabolic probe by Crivelli, Simone M., van Kruining, Daan, Luo, Qian, Stevens, Jo A. A., Giovagnoni, Caterina, Paulus, Andreas, Bauwens, Matthias, Berkes, Dusan, de Vries, Helga E., Mulder, Monique T., Walter, Jochen, Waelkens, Etienne, Derua, Rita, Swinnen, Johannes V., Dehairs, Jonas, Mottaghy, Felix M., Losen, Mario, Bieberich, Erhard, Martinez-Martinez, Pilar

“…The metabolism of ceramides is deregulated in the brain of Alzheimer’s disease (AD) patients and is associated with apolipoprotein (APO) APOE4 and amyloid-β…”
Get full text

Effects of Sex, Age, and Apolipoprotein E Genotype on Brain Ceramides and Sphingosine-1-Phosphate in Alzheimer’s Disease and Control Mice by den Hoedt, Sandra, Crivelli, Simone M., Leijten, Frank P. J., Losen, Mario, Stevens, Jo A. A., Mané-Damas, Marina, de Vries, Helga E., Walter, Jochen, Mirzaian, Mina, Sijbrands, Eric J. G., Aerts, Johannes M. F. G., Verhoeven, Adrie J. M., Martinez-Martinez, Pilar, Mulder, Monique T.

“…Apolipoprotein ε4 ( APOE )4 is a strong risk factor for the development of Alzheimer’s disease (AD) and aberrant sphingolipid levels have been implicated in…”
Get full text

Novel Isolation Method Reveals Sex-Specific Composition and Neurotoxicity of Small Extracellular Vesicles in a Mouse Model of Alzheimer's Disease by Elsherbini, Ahmed, Zhu, Zhihui, Quadri, Zainuddin, Crivelli, Simone M, Ren, Xiaojia, Vekaria, Hemendra J, Tripathi, Priyanka, Zhang, Liping, Zhi, Wenbo, Bieberich, Erhard

“…We developed a new method to isolate small extracellular vesicles (sEVs) from male and female wild-type and 5xFAD mouse brains to investigate the sex-specific…”
Get full text

CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease by Crivelli, Simone M., Luo, Qian, Stevens, Jo A.A., Giovagnoni, Caterina, van Kruining, Daan, Bode, Gerard, den Hoedt, Sandra, Hobo, Barbara, Scheithauer, Anna-Lena, Walter, Jochen, Mulder, Monique T., Exley, Christopher, Mold, Matthew, Mielke, Michelle M., De Vries, Helga E., Wouters, Kristiaan, van den Hove, Daniel L. A., Berkes, Dusan, Ledesma, María Dolores, Verhaagen, Joost, Losen, Mario, Bieberich, Erhard, Martinez-Martinez, Pilar

“…Abstract Background Dysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer’s disease (AD)…”
Get full text

Ceramide‐mediated orchestration of oxidative stress response through filopodia‐derived small extracellular vesicles by Quadri, Zainuddin, Elsherbini, Ahmed, Crivelli, Simone M., El‐Amouri, Salim S., Tripathi, Priyanka, Zhu, Zhihui, Ren, Xiaojia, Zhang, Liping, Spassieva, Stefka D., Nikolova‐Karakashian, Mariana, Bieberich, Erhard

“…Extracellular vesicles (EVs) are shed from the plasma membrane, but the regulation and function of these EVs remain unclear. We found that oxidative stress…”
Get full text

Plasma ceramides relate to mild cognitive impairment in middle-aged men: The Maastricht Study by van Kruining, Daan, Losen, Mario, Crivelli, Simone M, de Jong, Joost J A, Jansen, Jacobus F A, Backes, Walter H, Monereo-Sánchez, Jennifer, van Boxtel, Martin P J, Köhler, Sebastian, Linden, David E J, Schram, Miranda T, Mielke, Michelle M, Martinez-Martinez, Pilar

“…There is an urgent need for biomarkers identifying individuals at risk of early-stage cognitive impairment. Using cross-sectional data from The Maastricht…”
Get full text

CERTL reduces C16 ceramide, amyloid‐β levels and inflammation in a model of Alzheimer's disease by Crivelli, Simone M

“…Background Dysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer’s disease (AD). Ceramide…”
Get full text

Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody by Jiang, Xue, Zhu, Zhihui, Qin, Haiyan, Tripathi, Priyanka, Zhong, Liansheng, Elsherbini, Ahmed, Karki, Sanjib, Crivelli, Simone M, Zhi, Wenbo, Wang, Guanghu, Spassieva, Stefanka D, Bieberich, Erhard

“…Ceramide-rich platforms (CRPs) mediate association of proteins with the sphingolipid ceramide and may regulate protein interaction in membrane contact sites to…”
Get full text

Sphingolipids in Alzheimer's disease, how can we target them? by Crivelli, Simone M., Giovagnoni, Caterina, Visseren, Lars, Scheithauer, Anna-Lena, de Wit, Nienke, den Hoedt, Sandra, Losen, Mario, Mulder, Monique T., Walter, Jochen, de Vries, Helga E., Bieberich, Erhard, Martinez-Martinez, Pilar

“…Altered levels of sphingolipids and their metabolites in the brain, and the related downstream effects on neuronal homeostasis and the immune system, provide a…”
Get full text

Immunofluorescence Labeling of Lipid-Binding Proteins CERTs to Monitor Lipid Raft Dynamics by Giovagnoni, Caterina, Crivelli, Simone M, Losen, Mario, Martinez-Martinez, Pilar

“…Fluorescence microscopy is a powerful and widely used tool in molecular biology. Over the years, the discovery and development of lipid-binding fluorescent…”
Get more information

Extracellular Vesicles Containing Ceramide-Rich Platforms: "Mobile Raft" Isolation and Analysis by Elsherbini, Ahmed, Qin, Haiyan, Zhu, Zhihui, Tripathi, Priyanka, Wang, Guanghu, Crivelli, Simone M, Spassieva, Stefka D, Bieberich, Erhard

“…Extracellular vesicles (EVs) are secreted by eukaryotic cells and serve as carriers for a variety of cell signaling factors, including RNAs, proteins, and…”
Get more information

Cross-Link/Proximity Ligation Assay for Visualization of Lipid and Protein Complexes in Lipid Rafts by Tripathi, Priyanka, Zhu, Zhihui, Qin, Haiyan, Elsherbini, Ahmed, Roush, Emily A, Crivelli, Simone M, Spassieva, Stefka D, Bieberich, Erhard

“…The detection of protein complexes by coimmunoprecipitation or two-hybrid analysis is often limited to cytosolic and soluble proteins, while interaction…”
Get more information

The effects of APOE4 and familial Alzheimer's disease mutations on free fatty acid profiles in mouse brain are age‐ and sex‐dependent by Hoedt, Sandra, Crivelli, Simone M., Dorst‐Lagerwerf, Kristien Y., Leijten, Frank P. J., Losen, Mario, Vries, Helga E., Sijbrands, Eric J. G., Verhoeven, Adrie J. M., Martinez‐Martinez, Pilar, Mulder, Monique T.

“…APOE4 encoding apolipoprotein (Apo)E4 is the strongest genetic risk factor for Alzheimer's disease (AD). ApoE is key in intercellular lipid trafficking. Fatty…”
Get full text