Search Results - "Critz, Stuart"

Protein Kinase G Transmits the Cardioprotective Signal From Cytosol to Mitochondria by Costa, Alexandre D.T, Garlid, Keith D, West, Ian C, Lincoln, Thomas M, Downey, James M, Cohen, Michael V, Critz, Stuart D

“…Ischemic and pharmacological preconditioning can be triggered by an intracellular signaling pathway in which Gi-coupled surface receptors activate a cascade…”
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Protein kinase C protects preconditioned rabbit hearts by increasing sensitivity of adenosine A2b -dependent signaling during early reperfusion by Kuno, Atsushi, Critz, Stuart D, Cui, Lin, Solodushko, Victoriya, Yang, Xi-Ming, Krahn, Thomas, Albrecht, Barbara, Philipp, Sebastian, Cohen, Michael V, Downey, James M

“…Abstract Although protein kinase C (PKC) plays a key role in ischemic preconditioning (IPC), the actual mechanism of that protection is unknown. We recently…”
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Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection by Oldenburg, Olaf, Qin, Qining, Krieg, Thomas, Yang, Xi-Ming, Philipp, Sebastian, Critz, Stuart D, Cohen, Michael V, Downey, James M

“…Bradykinin (BK) mimics ischemic preconditioning by generating reactive oxygen species (ROS). To identify intermediate steps that lead to ROS generation, rabbit…”
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Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals by Pain, T, Yang, X M, Critz, S D, Yue, Y, Nakano, A, Liu, G S, Heusch, G, Cohen, M V, Downey, J M

“…The critical time for opening mitochondrial (mito) K(ATP) channels, putative end effectors of ischemic preconditioning (PC), was examined. In isolated rabbit…”
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The relative order of mKATP channels, free radicals and p38 MAPK in preconditioning's protective pathway in rat heart by YUANKUN YUE, QINING QIN, COHEN, Michael V, DOWNEY, James M, CRITZ, Stuart D

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p38 MAP kinase activation mediates γ-globin gene induction in erythroid progenitors by Pace, Betty S, Qian, Xin-hua, Sangerman, Jose, Ofori-Acquah, Solomon F, Baliga, B.Surendra, Han, Jiahuai, Critz, Stuart D

“…Our goal was to determine the role of p38 mitogen-activated protein kinase (MAPK) signaling in fetal hemoglobin (HbF) induction. Two histone deacetylase…”
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Ischemic Preconditioning Activates MAPKAPK2 in the Isolated Rabbit Heart: Evidence for Involvement of p38 MAPK by Nakano, Atsushi, Baines, Christopher P, Kim, Sung O, Pelech, Steven L, Downey, James M, Cohen, Michael V, Critz, Stuart D

“…ABSTRACTRecent studies suggest that p38 mitogen-activated protein kinase (MAPK) may be involved in ischemic preconditioning (PC). To further test this…”
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Mechanisms of acetylcholine- and bradykinin-induced preconditioning by Critz, Stuart D., Cohen, Michael V., Downey, James M.

“…Acetylcholine (ACh) and bradykinin (BK) are potent pharmacological agents which mimic ischemic preconditioning (IPC) enabling hearts to resist infarction…”
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Localizing extracellular signal-regulated kinase (ERK) in pharmacological preconditioning's trigger pathway by Philipp, Sebastian, Critz, Stuart D, Cui, Lin, Solodushko, Viktoriya, Cohen, Michael V, Downey, James M

“…Acetylcholine (ACh) and opioid receptor agonists trigger the preconditioned phenotype through sequential activation of the epidermal growth factor (EGF)…”
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Menadione mimics the infarct-limiting effect of preconditioning in isolated rat hearts by Yue, Y, Krenz, M, Cohen, M V, Downey, J M, Critz, S D

“…The role of mitochondrial free radicals in the cardioprotective effect of ischemic preconditioning was examined in isolated buffer-perfused rat hearts. Infarct…”
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S-T segment voltage during sequential coronary occlusions is an unreliable marker of preconditioning by Birincioglu, M, Yang, X M, Critz, S D, Cohen, M V, Downey, J M

“…During coronary angioplasty, a stair-step decrease in peak S-T segment elevation from the first to the second coronary occlusion has been assumed to indicate a…”
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Ischemia induced activation of heat shock protein 27 kinases and casein kinase 2 in the preconditioned rabbit heart by Kim, S O, Baines, C P, Critz, S D, Pelech, S L, Katz, S, Downey, J M, Cohen, M V

“…Protein kinase C (PKC), p38 MAP kinase, and mitogen-activated protein kinase-activated kinases 2 and 3 (MAPKAPK2 and MAPKAPK3) have been implicated in ischemic…”
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The p38 MAPK inhibitor, SB203580, abrogates ischaemic preconditioning in rat heart but timing of administration is critical by Mocanu, M M, Baxter, G F, Yue, Y, Critz, S D, Yellon, D M

“…There is debate concerning the involvement of p38 mitogen activated protein kinase (MAPK) in the mediation of ischaemic preconditioning. Pharmacological…”
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The domain of brain β-spectrin responsible for synaptic vesicle association is essential for synaptic transmission by Zimmer, Warren E., Zhao, Ying, Sikorski, Aleksander F., Critz, Stuart D., Sangerman, José, Elferink, Lisa A., Xu, X.Susan, Goodman, Steven R.

“…We have examined the interaction between synapsin I, the major phosphoprotein on the membrane of small synaptic vesicles, and brain spectrin. Using recombinant…”
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Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells by Krenz, Maike, Oldenburg, Olaf, Wimpee, Holly, Cohen, Michael V., Garlid, Keith D., Critz, Stuart D., Downey, James M., Benoit, Joseph N.

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Opening of Mitochondrial K ATP Channels Triggers the Preconditioned State by Generating Free Radicals by Pain, Tilley, Yang, Xi-Ming, Critz, Stuart D., Yue, Yankun, Nakano, Atsushi, Liu, Guang S., Heusch, Gerd, Cohen, Michael V., Downey, James M.

“…Abstract —The critical time for opening mitochondrial (mito) K ATP channels, putative end effectors of ischemic preconditioning (PC), was examined. In isolated…”
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Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on phosphatidylinositol 3- and Src-kinase activation and mitochondrial KATP channel opening by Oldenburg, O

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The relative order of mK(ATP) channels, free radicals and p38 MAPK in preconditioning's protective pathway in rat heart by Yue, Yuankun, Qin, Qining, Cohen, Michael V, Downey, James M, Critz, Stuart D

“…Ischemic preconditioning (PC) reduces myocardial infarction by a mechanism that involves opening of mitochondrial ATP-dependent potassium channels (mK(ATP)),…”
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Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on phosphatidylinositol 3- and Src-kinase activation and mitochondrial K ATP channel opening by Oldenburg, Olaf, Critz, Stuart D., Cohen, Michael V., Downey, James M.

“…Acetylcholine (ACh), like ischemic preconditioning (PC), protects against infarction and is dependent on generation of reactive oxygen species (ROS). To…”
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Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells by Krenz, Maike, Oldenburg, Olaf, Wimpee, Holly, Cohen, Michael V, Garlid, Keith D, Critz, Stuart D, Downey, James M, Benoit, Joseph N

“…Recent evidence suggests that opening of mitochondrial K(ATP) channels in cardiac muscle triggers the preconditioning phenomenon through free radical…”
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