Search Results - "Cristina Machón"

Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism by Cuervo, Ana, Fàbrega-Ferrer, Montserrat, Machón, Cristina, Conesa, José Javier, Fernández, Francisco J., Pérez-Luque, Rosa, Pérez-Ruiz, Mar, Pous, Joan, Vega, M. Cristina, Carrascosa, José L., Coll, Miquel

“…Double-stranded DNA bacteriophages package their genome at high pressure inside a procapsid through the portal, an oligomeric ring protein located at a unique…”
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Site-specific integration of foreign DNA into minimal bacterial and human target sequences mediated by a conjugative relaxase by Agúndez, Leticia, González-Prieto, Coral, Machón, Cristina, Llosa, Matxalen

“…Bacterial conjugation is a mechanism for horizontal DNA transfer between bacteria which requires cell to cell contact, usually mediated by self-transmissible…”
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Untwisting of the DNA helix stimulates the endonuclease activity of Bacillus subtilis Nth at AP sites by Collier, Christopher, Machón, Cristina, Briggs, Geoff S., Smits, Wiep Klaas, Soultanas, Panos

“…Bacterial nucleoid associated proteins play a variety of roles in genome maintenance and dynamics. Their involvement in genome packaging, DNA replication and…”
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A new domain of conjugative relaxase TrwC responsible for efficient oriT‐specific recombination on minimal target sequences by César, Carolina Elvira, Machón, Cristina, De La Cruz, Fernando, Llosa, Matxalen

“…Summary We show that relaxase TrwC promotes recombination between two directly repeated oriTs while related relaxases TraI of F and pKM101 do not. Efficient…”
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Co-directional replication–transcription conflicts lead to replication restart by Merrikh, Houra, Machón, Cristina, Grainger, William H., Grossman, Alan D., Soultanas, Panos

“…Transcription and replication in conflict As the rates of DNA replication and transcription are different, the machineries that carry out these processes are…”
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Atomic structure of the Epstein-Barr virus portal by Machón, Cristina, Fàbrega-Ferrer, Montserrat, Zhou, Daming, Cuervo, Ana, Carrascosa, José L., Stuart, David I., Coll, Miquel

“…Herpesviridae is a vast family of enveloped DNA viruses that includes eight distinct human pathogens, responsible for diseases that range from almost…”
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Structures of pMV158 replication initiator RepB with and without DNA reveal a flexible dual-function protein by Machón, Cristina, Ruiz-Masó, José A, Amodio, Juliana, Boer, D Roeland, Bordanaba-Ruiseco, Lorena, Bury, Katarzyna, Konieczny, Igor, Del Solar, Gloria, Coll, Miquel

“…DNA replication is essential to all living organisms as it ensures the fidelity of genetic material for the next generation of dividing cells. One of the…”
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Type IV traffic ATPase TrwD as molecular target to inhibit bacterial conjugation by Ripoll‐Rozada, Jorge, García‐Cazorla, Yolanda, Getino, María, Machón, Cristina, Sanabria‐Ríos, David, de la Cruz, Fernando, Cabezón, Elena, Arechaga, Ignacio

“…Summary Bacterial conjugation is the main mechanism responsible for the dissemination of antibiotic resistance genes. Hence, the search for specific…”
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Using a partial atomic model from medium‐resolution cryo‐EM to solve a large crystal structure by Fàbrega-Ferrer, Montserrat, Cuervo, Ana, Fernández, Francisco J., Machón, Cristina, Pérez-Luque, Rosa, Pous, Joan, Vega, M. Cristina, Carrascosa, José L., Coll, Miquel

“…Medium‐resolution cryo‐electron microscopy maps, in particular when they include a significant number of α‐helices, may allow the building of partial models…”
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Structure-Driven Discovery of α,γ-Diketoacid Inhibitors Against UL89 Herpesvirus Terminase by Bongarzone, Salvatore, Nadal, Marta, Kaczmarska, Zuzanna, Machón, Cristina, Álvarez, Mercedes, Albericio, Fernando, Coll, Miquel

“…Human cytomegalovirus (HCMV) is an opportunistic pathogen causing a variety of severe viral infections, including irreversible congenital disabilities…”
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Role of toxin ζ and starvation responses in the sensitivity to antimicrobials by Tabone, Mariangela, Lioy, Virginia S, Ayora, Silvia, Machón, Cristina, Alonso, Juan C

“…A fraction of otherwise antimicrobial-sensitive Bacillus subtilis cells, called persisters, are phenotypically tolerant of antimicrobial treatment. We report…”
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Conformational plasticity of RepB, the replication initiator protein of promiscuous streptococcal plasmid pMV158 by Boer, D. Roeland, Ruiz-Masó, José Angel, Rueda, Manuel, Petoukhov, Maxim V., Machón, Cristina, Svergun, Dmitri I., Orozco, Modesto, del Solar, Gloria, Coll, Miquel

“…DNA replication initiation is a vital and tightly regulated step in all replicons and requires an initiator factor that specifically recognizes the DNA…”
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Site-Specific Recombinase and Integrase Activities of a Conjugative Relaxase in Recipient Cells by Draper, Olga, Carolina Elvira César, Cristina Machón, de la Cruz, Fernando, Llosa, Matxalen

“…Conjugative relaxases are the proteins that initiate bacterial conjugation by a site-specific cleavage of the transferred DNA strand. In vitro, they show…”
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Nuclear Targeting of a Bacterial Integrase That Mediates Site-Specific Recombination between Bacterial and Human Target Sequences by Agúndez, Leticia, Machón, Cristina, César, Carolina Elvira, Rosa-Garrido, Manuel, Delgado, M. Dolores, Llosa, Matxalen

“…TrwC is a bacterial protein involved in conjugative transfer of plasmid R388. It is transferred together with the DNA strand into the recipient bacterial cell,…”
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Structural characterization of the OBD-nic covalent complex by Machón, Cristina, Ruiz-Masó, José Ángel, del Solar, Gloria, Coll, Miquel

“…Abstract only…”
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The ζ toxin induces a set of protective responses and dormancy by Lioy, Virginia S, Machon, Cristina, Tabone, Mariangela, Gonzalez-Pastor, José E, Daugelavicius, Rimantas, Ayora, Silvia, Alonso, Juan C

“…The ζε module consists of a labile antitoxin protein, ε, which in dimer form (ε(2)) interferes with the action of the long-living monomeric ζ…”
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DnaB proteolysis in vivo regulates oligomerization and its localization at oriC in Bacillus subtilis by Grainger, William H, Machón, Cristina, Scott, David J, Soultanas, Panos

“…Initiation of bacterial DNA replication at oriC is mediated by primosomal proteins that act cooperatively to melt an AT-rich region where the replicative…”
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Activation of Vibrio cholerae virulence: the structure of the one-component signal transduction regulator ToxR bound to virulence gene promoters toxT and ompU by Canals, Albert, Alcaide i Jiménez, Adrià, Pieretti, Simone, Machón, Cristina, Fàbrega-Ferrer, Montserrat, Muriel, Mireia, Pérez-Luque, Rosa, Krukonis, Eric S., Coll, Miquel

“…Abstract only…”
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Unsaturated fatty acids are inhibitors of bacterial conjugation by Fernandez-Lopez, Raul, Machon, Cristina, Longshaw, Christopher M, Martin, Steve, Molin, Soren, Zechner, Ellen L, Espinosa, Manuel, Lanka, Erich, de la Cruz, Fernando

“…1 Departamento de Biología Molecular (Unidad asociada al CIB, CSIC), Universidad de Cantabria, C. Herrera Oria s/n, E-39011 Santander, Spain 2 Cubist…”
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Single-Molecule Atomic Force Spectroscopy Reveals that DnaD Forms Scaffolds and Enhances Duplex Melting by Zhang, Wenke, Machón, Cristina, Orta, Alberto, Phillips, Nicola, Roberts, Clive J., Allen, Stephanie, Soultanas, Panos

“…The Bacillus subtilis DnaD is an essential DNA-binding protein implicated in replication and DNA remodeling. Using single-molecule atomic force spectroscopy,…”
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