Search Results - "Crist, Keith A."

Characterization of rat ovarian adenocarcinomas developed in response to direct instillation of 7,12-dimethylbenz[a]anthracene (DMBA) coated suture by Crist, Keith A., Zhang, Zhongqiu, You, Ming, Gunning, William T., Conran, Phillip B., Steele, Vernon E., Lubet, Ronald A.

“…Human ovarian cancer is predominantly of epithelial cell origin (>90% of malignant tumors) and most often presents at an advanced stage with poor prognosis…”
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Aromatase inhibitors increase the sensitivity of human tumor cells to monocyte-mediated, antibody-dependent cellular cytotoxicity by Braun, Donald P., Crist, Keith A., Shaheen, Fehr, Staren, Edgar D., Andrews, Stephen, Parker, Joanne

“…A randomized, placebo-controlled phase III trial of the breast cancer vaccine Theratope (Biomira Corporation, Edmonton, Alberta, Canada), which expresses the…”
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Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Lantry, Laura E., Zhang, Zhongqiu, Yao, Rusheng, Crist, Keith A., Wang, Yian, Ohkanda, Junko, Hamilton, Andrew D., Sebti, Said M., lubet, Ronald A., You, Ming

“…The Ras protein undergoes a series of post-translational modifications at the C-terminal CAAX motif, which culminates with the anchoring of p21 Ras to the…”
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CHEMOPREVENTIVE EFFICACY OF PROMISING FARNESYLTRANSFERASE INHIBITORS by Lantry, Laura E., Zhang, Zhongqiu, Crist, Keith A., Wang, Yian, Hara, Mitsunobu, Zeeck, Axel, Lubet, Ronald A., You, Ming

“…The studies presented were designed to test the efficacy of farnesyltransferase inhibitors (FTIs) as potential chemopreventive compounds in the mouse lung…”
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Altered gene expression profile in chemically induced rat mammary adenocarcinomas and its modulation by an aromatase inhibitor by YIAN WANG, LAN HU, RUISHENG YAO, MIN WANG, CRIST, Keith A, GRUBBS, Clinton J, JOHANNING, Gary L, LUBET, Ronald A, MING YOU

“…In the present study, competitive cDNA library screening (CCLS) and cDNA microarray analyses were employed to identify differentially expressed genes in…”
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Detection of genomic alterations in human endometrial cancer by two-dimensional gel electrophoresis by Pohlod-Miller, Susan, Fanning, James, Gu, Ping, Crist, Keith A., You, Ming

“…Objective: The purpose of this study was to detect genomic alterations in human endometrial cancer by two-dimensional gel electrophoresis. Study Design: With…”
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Effect of green tea on p53 mutation distribution in ultraviolet B radiation-induced mouse skin tumors by QING LIU, YUE WANG, A.CRIST, K, WANG, Z.-Y, LOU, Y.-R, HUANG, M.-T, CONNEY, A. H, MING YOU

“…In the present study, administration of green tea to SKH-1 mice, via the drinking fluid, was found to significantly reduce the incidence and volume of…”
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Brief communication, P53 accumulation in N-methyl-N-nitrosourea-induced rat mammary tumors by Crist, K A, Fuller, R D, Chaudhuri, B, Chaudhuri, P, You, M

“…P53 aberrant protein expression and mutation is a component of many human tumors but less information is available regarding involvement in relevant animal…”
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5-Aza-2'-deoxycytidine is chemopreventive in a 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone-induced primary mouse lung tumor model by LANTRY, L. E, ZHANG, Z, CRIST, K. A, WANG, Y, KELLOFF, G. J, LUBET, R. A, YOU, M

“…Carcinogenesis is a multistep process in which many alterations in both genetic and epigenetic controls lead to a growth advantage for neoplastic cells…”
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Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung by Lantry, Laura E., Zhang, Zhongqiu, Gao, Feng, Crist, Keith A., Wang, Yian, Kelloff, Gary J., Lubet, Ronald A., You, Ming

“…This study was designed to test the chemopreventive potential of perillyl alcohol, an inhibitor of farnesyltransferase, in a mouse lung tumor bioassay…”
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5-Aza-2'-deoxycyctidine is chemopreventive in a 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor model by Lantry, Laura E, Zhang, Zhongqiu, Crist, Keith A, Wang, Yian

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Additional Evidence That the K-ras Protooncogene is a Candidate for the Major Mouse Pulmonary Adenoma Susceptibility (Pas-1) Gene by Lin, Lin, Festing, Michael F. W., Devereux, Theodora R., Crist, Keith A., Christiansen, Steven C., Wang, Yian, Yang, Alice, Svenson, Karen, Paigen, Beverly, Malkinson, Alvin M., You, Ming

“…A locus for mouse pulmonary adenoma susceptibility, Pas-1, has been mapped on distal chromosome 6, where the K-ras gene is located. Allele-specific activation…”
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Chromosome 3p tumor-suppressor gene alterations in cervical carcinomas by Herzog, Christopher R., Crist, Keith A., Sabourin, Carol L. K., Kelloff, Gary J., Boone, Charles W., Stoner, Gary D., You, Ming

“…Loss of heterozygosity (LOH) on chromosome 3p is a common event in cervical cancer and typically occurs in a dispersed pattern involving several loci. This…”
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Tissue-specific expression of the K-ras allele from the A/J parent in (A/J x TSG-p53) F1 mice by Matzinger, S A, Chen, B, Wang, Y, Crist, K A, Stoner, G D, Kelloff, G J, Lubet, R A, You, M

“…Tissue-specific expression of parental K-ras allele(s) was investigated by single-strand conformation polymorphism analysis of the 3' untranslated region of…”
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Tissue-specific expression of the K- ras allele from the A/J parent in (A/J×TSG- p53) F 1 mice by Matzinger, Steven A., Chen, Bin, Wang, Yian, Crist, Keith A., Stoner, Gary D., Kelloff, Gary J., Lubet, Ronald A., You, Ming

“…Tissue-specific expression of parental K- ras allele(s) was investigated by single-strand conformation polymorphism analysis of the 3′ untranslated region of…”
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Effects of culture duration on hydrogen peroxide-induced hepatocyte toxicity by Ruch, R J, Crist, K A, Klaunig, J E

“…The effects of culture duration on primary cultured mouse hepatocyte antioxidant levels (superoxide dismutase, catalase, glutathione peroxidase, vitamin E, and…”
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Detection of differentially expressed genes in Methylnitrosourea-induced rat mammary adenocarcinomas by Hu, Lan, Lin, Lin, Crist, Keith A., Kelloff, Gary J., Steele, Vernon E., Lubet, Ronald A., You, Ming, Wang, Yian

“…In this study, altered gene expression in five methylnitrosourea (MNU)‐induced rat mammary adenocarcinomas was investigated using a newly developed competitive…”
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Ductal carcinoma in situ in rat mammary gland by Crist, K A, Chaudhuri, B, Shivaram, S, Chaudhuri, P K

“…Antiestrogen therapy has been proposed as a treatment option for ductal carcinoma in situ (DCIS). However, its effectiveness has not been evaluated in the…”
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Effect of early vs. late administration of 4-Hydroxyphenylretinamide (4-HPR) on N-Methyl-N-Nitrosourea (MNU)-induced mammary tumorigenesis by Crist, Keith A., Wang, Yian, Lubet, Ronald A., Steele, Vernon E., Kelloff, Gary J., You, Ming

“…Mammary tumors were induced in 48–52‐day‐old female Sprague‐Dawley rats in metestrus or diestrus with a single jugular injection of MNU (50 mg/kg). Control…”
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DNA quantification in cervical intraepithelial neoplasia thick tissue sections by confocal laser scanning microscopy by Crist, Keith A., Kim, Kitai, Goldblatt, Peter J., Boone, Charles W., Kelloff, Gary, J., You, Ming

“…Image analysis of tissue biopsies for determination of DNA content as an early marker of neoplasia is hampered by the complexity of corrections necessary to…”
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