Search Results - "Crison, John R."

Biowaiver approach for biopharmaceutics classification system class 3 compound metformin hydrochloride using in silico modeling by Crison, John R, Timmins, Peter, Keung, Anther, Upreti, Vijay V, Boulton, David W, Scheer, Barry J

“…The dependency of metformin in vivo disposition on the rate and extent of dissolution was studied. The analysis includes the use of fundamental principles of…”
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Investigation of some factors contributing to negative food effects by Marasanapalle, Venugopal P., Crison, John R., Ma, Jingwen, Li, Xiaoling, Jasti, Bhaskara R.

“…A drug is defined as exhibiting negative food effects, if the co‐administration of food statistically decreases its area under the curve, AUC, when compared…”
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The biopharmaceutics risk assessment roadmap for optimizing clinical drug product performance by Selen, Arzu, Dickinson, Paul A, Müllertz, Anette, Crison, John R, Mistry, Hitesh B, Cruañes, Maria T, Martinez, Marilyn N, Lennernäs, Hans, Wigal, Tim L, Swinney, David C, Polli, James E, Serajuddin, Abu T M, Cook, Jack A, Dressman, Jennifer B

“…The biopharmaceutics risk assessment roadmap (BioRAM) optimizes drug product development and performance by using therapy-driven target drug delivery profiles…”
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Optimizing Clinical Drug Product Performance: Applying Biopharmaceutics Risk Assessment Roadmap (BioRAM) and the BioRAM Scoring Grid by Dickinson, Paul A, Kesisoglou, Filippos, Flanagan, Talia, Martinez, Marilyn N, Mistry, Hitesh B, Crison, John R, Polli, James E, Cruañes, Maria T, Serajuddin, Abu T M, Müllertz, Anette, Cook, Jack A, Selen, Arzu

“…The aim of Biopharmaceutics Risk Assessment Roadmap (BioRAM) and the BioRAM Scoring Grid is to facilitate optimization of clinical performance of drug…”
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Mechanistic insights into the scale-up of the roller compaction process: a practical and dimensionless approach by Rowe, Jasmine M, Crison, John R, Carragher, Thomas J, Vatsaraj, Nipa, McCann, Ryan J, Nikfar, Faranak

“…Although the roller compaction process appears simple, efforts to quantitatively model the process have proven challenging because of complex material behavior…”
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A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability by Amidon, G L, Lennernäs, H, Shah, V P, Crison, J R

“…A biopharmaceutics drug classification scheme for correlating in vitro drug product dissolution and in vivo bioavailability is proposed based on recognizing…”
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Predictive models for drugs exhibiting negative food effects based on their biopharmaceutical characteristics by Marasanapalle, Venugopal P., Crison, John R., Devarakonda, Krishna R., Li, Xiaoling, Jasti, Bhaskara R.

“…Context: A drug is defined to exhibit food effects if its pharmacokinetic parameter, area under the curve (AUC0-∞) is different when co-administered with food…”
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Transport approaches to the biopharmaceutical design of oral drug delivery systems: prediction of intestinal absorption by Yu, Lawrence X., Lipka, Elke, Crison, John R., Amidon, Gordon L.

“…For almost a half century scientists have striven to develop a theoretical model capable of predicting oral drug absorption in humans. From the pH-partition…”
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Dissolution of ionizable water-insoluble drugs: the combined effect of pH and surfactant by Jinno, J, Oh, D m, Crison, J R, Amidon, G L

“…This study reports the results of the combined effect of pH and surfactant on the dissolution of piroxicam (PX), an ionizable water-insoluble drug in…”
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Compartmental transit and dispersion model analysis of small intestinal transit flow in humans by Yu, Lawrence X., Crison, John R., Amidon, Gordon L.

“…The purpose of this investigation was to characterize the small intestinal transit flow in humans using quantitative and mechanistic approaches. We presented a…”
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Preface by Crison, John R, Fleisher, David

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Drug Delivery Systems for Bone Disorders by CRISON, John R, FLEISHER, David

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Developing Dissolution Tests for Modified Release Dosage Forms: General Considerations by Crison, John R.

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Novel approach to the analysis of in vitro-in vivo relationships by Polli, J E, Crison, J R, Amidon, G L

“…The objective of this study was to quantify the dependence of degree of in vitro-in vivo correlation on the relative rates of dissolution and intestinal…”
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Dissolution media for in vitro testing of water-insoluble drugs: effect of surfactant purity and electrolyte on in vitro dissolution of carbamazepine in aqueous solutions of sodium lauryl sulfate by Crison, J R, Weiner, N D, Amidon, G L

“…The intrinsic dissolution rate and solubility of carbamazepine was measured in aqueous solutions of sodium lauryl sulfate (SLS) prepared with two different…”
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Drug dissolution into micellar solutions: development of a convective diffusion model and comparison to the film equilibrium model with application to surfactant-facilitated dissolution of carbamazepine by Crison, J R, Shah, V P, Skelly, J P, Amidon, G L

“…The intrinsic dissolution rate of carbamazepine in solutions of sodium lauryl sulfate was measured to study the convective diffusion transport of drug-loaded…”
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Permeability and clearance views of drug absorption: a commentary by Lennernäs, H, Crison, J R, Amidon, G L

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