Search Results - "Crimeen, Blessing"

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone by Vrahnas, Christina, Blank, Martha, Dite, Toby A., Tatarczuch, Liliana, Ansari, Niloufar, Crimeen-Irwin, Blessing, Nguyen, Huynh, Forwood, Mark R., Hu, Yifang, Ikegame, Mika, Bambery, Keith R., Petibois, Cyril, Mackie, Eleanor J., Tobin, Mark J., Smyth, Gordon K., Oakhill, Jonathan S., Martin, T. John, Sims, Natalie A.

“…Mineralized bone forms when collagen-containing osteoid accrues mineral crystals. This is initiated rapidly (primary mineralization), and continues slowly…”
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Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte‐Derived Parathyroid Hormone‐Related Protein by Ansari, Niloufar, Ho, Patricia WM, Crimeen‐Irwin, Blessing, Poulton, Ingrid J, Brunt, Athena R, Forwood, Mark R, Divieti Pajevic, Paola, Gooi, Jonathan H, Martin, T John, Sims, Natalie A

“…ABSTRACT Parathyroid hormone–related protein (PTHrP) and parathyroid hormone (PTH) have N‐terminal domains that bind a common receptor, PTHR1. N‐terminal PTH…”
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Retinoic Acid Receptor γ Activity in Mesenchymal Stem Cells Regulates Endochondral Bone, Angiogenesis, and B Lymphopoiesis by Green, Alanna C, Rudolph‐Stringer, Victoria, Straszkowski, Lenny, Tjin, Gavin, Crimeen‐Irwin, Blessing, Walia, Mannu, Martin, T John, Sims, Natalie A, Purton, Louise E

“…ABSTRACT Retinoic acid receptor (RAR) signaling regulates bone structure and hematopoiesis through intrinsic and extrinsic mechanisms. This study aimed to…”
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Dmp1Cre‐directed knockdown of parathyroid hormone–related protein (PTHrP) in murine decidua is associated with a life‐long increase in bone mass, width, and strength in male progeny by Ansari, Niloufar, Isojima, Tsuyoshi, Crimeen‐Irwin, Blessing, Poulton, Ingrid J., McGregor, Narelle E., Ho, Patricia W. M., Forwood, Mark R., Kovacs, Christopher S., Dimitriadis, Evdokia, Gooi, Jonathan H., Martin, T. John, Sims, Natalie A.

“…ABSTRACT Parathyroid hormone–related protein (PTHrP, gene name Pthlh) is a pleiotropic regulator of tissue homeostasis. In bone, Dmp1Cre‐targeted PTHrP…”
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The effect of carbamazepine on bone structure and strength in control and osteogenesis imperfecta (Col1a2 +/p.G610C) mice by Blank, Martha, McGregor, Narelle E., Rowley, Lynn, Kung, Louise H. W., Crimeen‐Irwin, Blessing, Poulton, Ingrid J., Walker, Emma C., Gooi, Jonathan H., Lamandé, Shireen R., Sims, Natalie A., Bateman, John F.

“…The inherited brittle bone disease osteogenesis imperfecta (OI) is commonly caused by COL1A1 and COL1A2 mutations that disrupt the collagen I triple helix…”
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EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis by Tonna, Stephen, Takyar, Farzin M., Vrahnas, Christina, Crimeen‐Irwin, Blessing, Ho, Patricia W. M., Poulton, Ingrid J., Brennan, Holly J., McGregor, Narelle E., Allan, Elizabeth H., Nguyen, Huynh, Forwood, Mark R., Tatarczuch, Liliana, Mackie, Eleanor J., Martin, T. John, Sims, Natalie A.

“…Cells that form bone (osteoblasts) express both ephrinB2 and EphB4, and previous work has shown that pharmacological inhibition of the eph‐rinB2/EphB4…”
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EphrinB2/EphB4 inhibition in the osteoblast lineage modifies the anabolic response to parathyroid hormone by Takyar, Farzin M, Tonna, Stephen, Ho, Patricia WM, Crimeen‐Irwin, Blessing, Baker, Emma K, Martin, T John, Sims, Natalie A

“…Previous reports indicate that ephrinB2 expression by osteoblasts is stimulated by parathyroid hormone (PTH) and its related protein (PTHrP) and that…”
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EphrinB2 Regulation by PTH and PTHrP Revealed by Molecular Profiling in Differentiating Osteoblasts by Allan, Elizabeth H, Häusler, Karl D, Wei, Tao, Gooi, Jonathan H, Quinn, Julian MW, Crimeen‐Irwin, Blessing, Pompolo, Sueli, Sims, Natalie A, Gillespie, Matthew T, Onyia, Jude E, Martin, T John

“…With the aim of identifying new pathways and genes regulated by PTH(1–34) and PTH‐related protein 1–141 [PTHrP(1–141)] in osteoblasts, this study was carried…”
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IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis by McGregor, Narelle E., Murat, Melissa, Elango, Jeevithan, Poulton, Ingrid J., Walker, Emma C., Crimeen-Irwin, Blessing, Ho, Patricia W.M., Gooi, Jonathan H., Martin, T. John, Sims, Natalie A.

“…Interleukin 6 (IL-6) supports development of bone-resorbing osteoclasts by acting early in the osteoblast lineage via membrane-bound (cis) or soluble (trans)…”
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Size-Dependent Immunogenicity: Therapeutic and Protective Properties of Nano-Vaccines against Tumors by Fifis, Theodora, Gamvrellis, Anita, Crimeen-Irwin, Blessing, Pietersz, Geoffrey A, Li, Jie, Mottram, Patricia L, McKenzie, Ian F. C, Plebanski, Magdalena

“…Infection can protect against subsequent disease by induction of both humoral and cellular immunity, but inert protein-based vaccines are not as effective. In…”
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Type 1 and 2 Immunity Following Vaccination Is Influenced by Nanoparticle Size:  Formulation of a Model Vaccine for Respiratory Syncytial Virus by Mottram, Patricia L, Leong, David, Crimeen-Irwin, Blessing, Gloster, Simone, Xiang, Sue D, Meanger, Jayesh, Ghildyal, Reena, Vardaxis, Nicholas, Plebanski, Magdalena

“…Previous studies compared uptake by dendritic cells (DC) of 20, 40, 100, 200, 500, 1000, and 2000 nm beads in vivo. When beads were used as antigen carriers,…”
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Author Correction: Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone by Vrahnas, Christina, Blank, Martha, Dite, Toby A., Tatarczuch, Liliana, Ansari, Niloufar, Crimeen-Irwin, Blessing, Nguyen, Huynh, Forwood, Mark R., Hu, Yifang, Ikegame, Mika, Bambery, Keith R., Petibois, Cyril, Mackie, Eleanor J., Tobin, Mark J., Smyth, Gordon K., Oakhill, Jonathan S., Martin, T. John, Sims, Natalie A.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Ligand Binding Determines Whether CD46 Is Internalized by Clathrin-coated Pits or Macropinocytosis by Crimeen-Irwin, Blessing, Ellis, Sarah, Christiansen, Dale, Ludford-Menting, Mandy J., Milland, Julie, Lanteri, Marc, Loveland, Bruce E., Gerlier, Denis, Russell, Sarah M.

“…CD46 is a ubiquitous human cell surface receptor for the complement components C3b and C4b and for various pathogens, including the measles virus and human…”
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Correction: Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification by Tonna, Stephen, Poulton, Ingrid J, Taykar, Farzin, Ho, Patricia W M, Tonkin, Brett, Crimeen-Irwin, Blessing, Tatarczuch, Liliana, McGregor, Narelle E, Mackie, Eleanor J, Martin, T John, Sims, Natalie A

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The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts by Ludford-Menting, Mandy J., Crimeen-Irwin, Blessing, Oliaro, Jane, Pasam, Anupama, Williamson, David, Pedersen, Natalie, Guillaumot, Patricia, Christansen, Dale, Manie, Serge, Gaus, Katharina, Russell, Sarah M.

“…Many infectious agents utilize CD46 for infection of human cells, and therapeutic applications of CD46-binding viruses are now being explored. Besides…”
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A Functional Interaction between CD46 and DLG4 by Ludford-Menting, Mandy J., Thomas, Suzanne J., Crimeen, Blessing, Harris, Lisa J., Loveland, Bruce E., Bills, Margaret, Ellis, Sarah, Russell, Sarah M.

“…Using a yeast two-hybrid screen, we identified a physical interaction between CD46 and DLG4. CD46 is a ubiquitous human cell-surface receptor for the…”
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Glycoprotein130 (Gp130)/interleukin-6 (IL-6) signalling in osteoclasts promotes bone formation in periosteal and trabecular bone by Johnson, Rachelle W, McGregor, Narelle E, Brennan, Holly J, Crimeen-Irwin, Blessing, Poulton, Ingrid J, Martin, T. John, Sims, Natalie A

“…Abstract Interleukin-6 (IL-6) and interleukin-11 (IL-11) receptors (IL-6R and IL-11R, respectively) are both expressed in osteoclasts and transduce signal via…”
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A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization by Ludford-Menting, Mandy J, Thomas, Suzanne J, Crimeen, Blessing, Harris, Lisa J, Loveland, Bruce E, Bills, Margaret, Ellis, Sarah, Russell, Sarah M

“…Using a yeast two-hybrid screen, we identified a physical interaction between CD46 and DLG4. CD46 is a ubiquitous human cell-surface receptor for the…”
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Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification by Tonna, Stephen, Poulton, Ingrid J, Taykar, Farzin, Ho, Patricia W M, Tonkin, Brett, Crimeen-Irwin, Blessing, Tatarczuch, Liliana, McGregor, Narelle E, Mackie, Eleanor J, Martin, T John, Sims, Natalie A

“…The majority of the skeleton arises by endochondral ossification, whereby cartilaginous templates expand and are resorbed by osteoclasts then replaced by…”
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EphrinB2 in osteocytes is essential for lysosome formation and collagen arrangement by Blank, Martha, Crimeen-Irwin, Blessing, Dutt, Mriga, Parker, Benjamin L., Nowell, Cameron J., Martin, T. John, Sims, Natalie A.

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