Search Results - "Crilly, E"
-
1
Conformational specificity of opioid receptors is determined by subcellular location irrespective of agonist
Published in eLife (20-05-2021)“…The prevailing model for the variety in drug responses is that they stabilize distinct active states of their G protein-coupled receptor (GPCR) targets,…”
Get full text
Journal Article -
2
A multicentre review of the direct-access mammography programme in Ireland for women with breast pain
Published in Clinical radiology (01-02-2024)“…To assess the current use of the direct access mammography pathway for breast pain and the rate of breast cancer detection in this patient cohort. A…”
Get full text
Journal Article -
3
Compartmentalized GPCR Signaling from Intracellular Membranes
Published in The Journal of membrane biology (01-06-2021)“…G protein-coupled receptors (GPCRs) are integral membrane proteins that transduce a wide array of inputs including light, ions, hormones, and neurotransmitters…”
Get full text
Journal Article -
4
Prevalence and predictors of loss to follow‐up in young adults with mild haemophilia
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01-01-2017)Get full text
Journal Article -
5
Combinatorial expression of GPCR isoforms affects signalling and drug responses
Published in Nature (London) (26-11-2020)“…G-protein-coupled receptors (GPCRs) are membrane proteins that modulate physiology across human tissues in response to extracellular signals. GPCR-mediated…”
Get full text
Journal Article -
6
Dual RXR motifs regulate nerve growth factor-mediated intracellular retention of the delta opioid receptor
Published in Molecular biology of the cell (01-03-2019)“…The delta opioid receptor (DOR), a physiologically relevant prototype for G protein-coupled receptors, is retained in intracellular compartments in neuronal…”
Get full text
Journal Article -
7
Spatial encoding of GPCR signaling in the nervous system
Published in Current opinion in cell biology (01-04-2019)“…Several GPCRs, including receptors previously thought to signal primarily from the cell surface, have been recently shown to signal from many intracellular…”
Get full text
Journal Article -
8
Location-biased activation of the proton-sensor GPR65 is uncoupled from receptor trafficking
Published in Proceedings of the National Academy of Sciences - PNAS (26-09-2023)“…The canonical view of G protein-coupled receptor (GPCR) function is that receptor trafficking is tightly coupled to signaling. GPCRs remain on the plasma…”
Get full text
Journal Article -
9
Author Correction: Combinatorial expression of GPCR isoforms affects signalling and drug responses
Published in Nature (London) (17-12-2020)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text
Journal Article -
10
Spectrin Tetramer Formation Is Not Required for Viable Development in Drosophila
Published in The Journal of biological chemistry (09-01-2015)“…The dominant paradigm for spectrin function is that (αβ)2-spectrin tetramers or higher order oligomers form membrane-associated two-dimensional networks in…”
Get full text
Journal Article -
11
Subcellular Location‐Dependent Activation and Signaling of the Delta‐Opioid Receptor
Published in The FASEB journal (01-04-2020)“…Abstract only…”
Get full text
Journal Article -
12
Model for water transport into powdered xanthan combining gel swelling and vapor diffusion
Published in Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics (01-10-2000)“…Water ingress into xanthan powder compressed to various packing densities has been studied using nuclear magnetic resonance stray field imaging (STRAFI). A…”
Get full text
Journal Article -
13
Combinatorial expression of functionally distinct GPCR isoforms can diversify receptor signalling response
Published in Nature (London) (01-11-2020)“…G protein-coupled receptors (GPCRs) are transmembrane proteins that modulate physiology across diverse tissues in response to extracellular signals. GPCR…”
Get full text
Journal Article -
14
The Use of Transgenic Animals in the European Union: The Report and Recommendations of ECVAM Workshop 28
Published in Alternatives to laboratory animals (01-01-1998)Get more information
Journal Article -
15
Bioethical Issues in the Generation and Use of Transgenic Farm Animals
Published in Alternatives to laboratory animals (01-11-1999)“…The use of transgenic farm animals presents many challenges to the bioethicist, not least how to analyse the ethical issues within a framework that does not…”
Get full text
Journal Article -
16
An ethical analysis of the use of xenografts in human transplant surgery
Published in Bulletin of medical ethics (01-03-1996)Get more information
Journal Article -
17
The Use of Transgenic Animals in the European Union: The Report and Recommendations of ECVAM Workshop 28
Published in Alternatives to laboratory animals (01-11-1999)Get full text
Journal Article -
18
Supporting relatives of adults with chronic mental illness in the community: A comparative evaluation of two groups
Published in Practice (Birmingham, England) (1998)“…Relatives of adults with chronic mental illness are recognised as an important provider of care for this vulnerable population. Carers, alongside service…”
Get full text
Journal Article -
19
Securities Regulation: Insider Status in Legal Fiction and Financial Fact. A Proposed Revision to Section 16(b)
Published in California law review (01-08-1962)Get full text
Journal Article -
20