Search Results - "Criddle, DN"

Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models by Wen, Li, Voronina, Svetlana, Javed, Muhammad A, Awais, Muhammad, Szatmary, Peter, Latawiec, Diane, Chvanov, Michael, Collier, David, Huang, Wei, Barrett, John, Begg, Malcolm, Stauderman, Ken, Roos, Jack, Grigoryev, Sergey, Ramos, Stephanie, Rogers, Evan, Whitten, Jeff, Velicelebi, Gonul, Dunn, Michael, Tepikin, Alexei V, Criddle, David N, Sutton, Robert

“…Background & Aims Sustained activation of the cytosolic calcium concentration induces injury to pancreatic acinar cells and necrosis. The calcium…”
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A microRNA checkpoint for Ca2+ signaling and overload in acute pancreatitis by Du, Wenya, Liu, Geng, Shi, Na, Tang, Dongmei, Ferdek, Pawel E., Jakubowska, Monika A., Liu, Shiyu, Zhu, Xinyue, Zhang, Jiayu, Yao, Linbo, Sang, Xiongbo, Zou, Sailan, Liu, Tingting, Mukherjee, Rajarshi, Criddle, David N., Zheng, Xiaofeng, Xia, Qing, Berggren, Per-Olof, Huang, Wendong, Sutton, Robert, Tian, Yan, Huang, Wei, Fu, Xianghui

“…Acute pancreatitis (AP) is a common digestive disease without specific treatment, and its pathogenesis features multiple deleterious amplification loops…”
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Intracellular rupture, exocytosis and actin interaction of endocytic vacuoles in pancreatic acinar cells: initiating events in acute pancreatitis by Chvanov, Michael, Faveri, Francesca, Moore, Danielle, Sherwood, Mark W., Awais, Muhammad, Voronina, Svetlana, Sutton, Robert, Criddle, David N., Haynes, Lee, Tepikin, Alexei V.

“…Key points Giant trypsin‐containing endocytic vacuoles are formed in pancreatic acinar cells stimulated with inducers of acute pancreatitis. F‐actin envelops…”
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Fatty Acid Ethyl Esters Cause Pancreatic Calcium Toxicity via Inositol Trisphosphate Receptors and Loss of ATP Synthesis by Criddle, David N., Murphy, John, Fistetto, Gregorio, Barrow, Stephanie, Tepikin, Alexei V., Neoptolemos, John P., Sutton, Robert, Petersen, Ole H.

“…Fatty acid ethyl esters are ethanol metabolites inducing sustained, toxic elevations of the acinar cytosolic free calcium ion concentration ([Ca2+]C)…”
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Ethanol Toxicity in Pancreatic Acinar Cells: Mediation by Nonoxidative Fatty Acid Metabolites by Criddle, David N., Michael G. T. Raraty, Neoptolemos, John P., Tepikin, Alexei V., Petersen, Ole H., Sutton, Robert, Burgen, Arnold S.

“…Ethanol causes pancreatic damage by an unknown mechanism. Previously, we demonstrated that a sustained rise of the cytosolic Ca2+concentration ([ Ca2+]i)…”
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Menadione-induced oxidative stress modulates mitochondrial bioenergetics in pancreatic acinar cells by Armstrong, J, Sutton, R, Criddle, D.N

“…Methods: Mitochondrial respiration (oxygen consumption rate: OCR) and glycolysis (extracellular acidification rate: ECAR) were measured in isolated murine…”
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Therapeutic potential of pyruvate in acute pancreatitis: In Vitro findings and a systematic review by Huang, W, Xiong, J.J, Cheng, C.R, Szatmary, P, Chvanov, M, Criddle, D.N, Xia, Q, Sutton, R

“…Background: In acute pancreatitis (AP) there is an increase in glycolysis in pancreatic acinar cells (PACs), providing ATP during mitochondrial impairment…”
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The role of receptor interacting protein kinase 1 (RIPK1) in bile acid-induced pancreatic acinar cell death by Ouyang, Yulin, Voronina, S, Chvanov, M, Wen, L, Latawiec, D, Awais, M, Armstrong, J.A, Bertin, J, Gough, P.J, Tepikin, A, Mukherjee, R, Sutton, R, Criddle, D.N

“…The effects of RIPK1 inhibitors on bile acid (500 [micro]M TLCS)-induced necrotic (Propidium iodide; PI) and apoptotic (caspase3/7 Green) cell death pathway…”
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Bridging the gap between bench and bedside: Systematic review of treatment in experimental acute pancreatitis by Javed, M.A, Altaf, K, Huang, W, Criddle, D.N, Sutton, R

“…Modes of action included microcirculatory modification [Trials (T) 38, Compounds (C) 19; RCTs 4, Multiple compounds in individual RCTs (CRCT) 2],…”
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Bridging the gap between bench and bedside: Systematic review of treatment in experimental acute pancreatitis by Javed, M.A, Altaf, K, Wei, H, Criddle, D.N, Sutton, R

“…Category: Benign and Inflammatory Introduction: Experimental animal models of acute pancreatitis (AP) are well characterised, have been used to investigate…”
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Bridging the gap between bench and bedside: Systematic review of treatment in experimental acute pancreatitis by Javed, M.A, Altaf, K, Huang, W, Criddle, D.N, Sutton, R

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Caffeine does not protect against L-arginine-induced acute pancreatitis in mice by Jin, T, Wen, L, Javed, M.A, Huang, W, Tepikin, A, Criddle, D.N, Xia, Q, Sutton, R

“…Background: We have previously shown that caffeine (25 mg/kg hourly ip x 7) protects against both caerulein- and bile acid-induced acute pancreatitis in mice…”
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Involvement of MPTP in minocycline – induced mitochondrial dysfunction in murine pancreatic acinar cells by Javed, M.A, Li, W, Collier, D, Jin, T, Wei, H, Tepikin, A, Criddle, D.N, Sutton, R

“…Category: Benign and Inflammatory Introduction: Mitochondrial dysfunction is considered a key feature of pancreatic injury induced by diverse precipitants of…”
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Inhibitory effects of minocycline on mitochondrial function in murine pancreatic acinar cells: involvement of the MPTP by Javed, M.A, Collier, D, Evans, A, Ehsan, A, Tepikin, A, Sutton, R, Criddle, D.N

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Antinociceptive activity of Calotropis procera latex in mice by Soares, Paula Matias, Lima, Silvane R., Matos, Samara G., Andrade, Marcelo M., Patrocínio, Manoel C.A., de Freitas, Cleverson D.T., Ramos, Márcio V., Criddle, David N., Cardi, Bruno A., Carvalho, Krishnamurti M., Assreuy, Ana Maria S., Vasconcelos, Silvânia M.M.

“…This work evaluated the antinociceptive effect of proteins from the Calotropis procera (Asclepiadaceae) latex using three different experimental models of…”
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Native crystal structure of a nitric oxide-releasing lectin from the seeds of Canavalia maritima by Gadelha, Carlos Alberto de Almeida, Moreno, Frederico Bruno Mendes Batista, Santi-Gadelha, Tatiane, Cajazeiras, João Batista, Rocha, Bruno Anderson Matias da, Assreuy, Ana Maria Sampaio, Lima Mota, Mário Rogério, Pinto, Nilson Vieira, Passos Meireles, Ana Vaneska, Borges, Júlio César, Freitas, Beatriz Tupinamba, Canduri, Fernanda, Souza, Emmanuel Prata, Delatorre, Plínio, Criddle, David Neil, de Azevedo, Walter Filgueira, Cavada, Benildo Sousa

“…Here, we report the crystallographic study of a lectin from Canavalia maritima seeds (ConM) and its relaxant activity on vascular smooth muscle, to provide new…”
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Comparative effects of caffeine metabolites on ca2+ signalling, cellular necrosis and acute pancreatitis by Cane, M.C, Huang, W, Tepikin, A.V, Sutton, R, Criddle, D.N

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Da-Cheng-Qi Decoction (DCQD) protects against pancreatic damage in murine experimental acute pancreatitis (AP) by Huang, W, Jin, T, Javed, M.A, Wen, L, Nunes, Q.M, Chvanov, M, Tepikin, A, Criddle, D.N, Xia, Q, Sutton, R

“…In the ARG-AP, mice received DCQD at 24 and 48 h after the 1st injection of L-Arginine, and were sacrificed at 72 h. In the TLCS-AP, DCQD was administered 2 h…”
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Involvement of the MPTP in minocycline-induced mitochondrial dysfunction in murine pancreatic acinar cells by Javed, M.A, Li, W, Collier, D, Jin, T, Huang, W, Awais, M, Tepikin, A, Criddle, D.N, Sutton, R

“…Introduction: Mitochondrial dysfunction is a key feature of pancreatic injury leading to acute pancreatitis (AP), which may be mediated via formation of the…”
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Da-Cheng-Qi decoction protects against pancreatic damage in murine experimental acute pancreatitis by Huang, W, Jin, T, Javed, M.A, Wen, L, Nunes, Q.M, Chvanov, M, Tepikin, A, Criddle, D.N, Xia, Q, Sutton, R

“…In the ARG-AP, mice received DCQD at 24 and 48 h after the 1st injection of L-Arginine, and were sacrificed at 72 h. In the TLCS-AP, DCQD was administered 2 h…”
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