Search Results - "Crichton, H."
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Short-term mortality and morbidity of very low-birthweight infants over 9 years at Groote Schuur Hospital, Cape Town, South Africa
Published in SAJCH : the South African journal of child health (01-06-2024)“…\r\nBackground\r\nWith the advancement of neonatal care there has been a decrease in mortality rates of very low-birthweight (VLBW) (≤1 500 g) infants…”
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Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline
Published in Cellular and molecular life sciences : CMLS (01-05-2014)“…The viability of any species requires that the genome is kept stable as it is transmitted from generation to generation by the germ cells. One of the…”
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Defects in meiotic recombination delay progression through pachytene in Tex19.1−/− mouse spermatocytes
Published in Chromosoma (01-12-2018)“…Recombination, synapsis, chromosome segregation and gene expression are co-ordinately regulated during meiosis to ensure successful execution of this…”
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Tex19.1 promotes Spo11-dependent meiotic recombination in mouse spermatocytes
Published in PLoS genetics (14-07-2017)“…Meiosis relies on the SPO11 endonuclease to generate the recombinogenic DNA double strand breaks (DSBs) required for homologous chromosome synapsis and…”
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Neonatal and paediatric bloodstream infections : pathogens, antimicrobial resistance patterns and prescribing practice at Khayelitsha District Hospital, Cape Town, South Africa
Published in South African medical journal (01-02-2018)“…Background. The epidemiology of neonatal and paediatric community-acquired and healthcare-associated bloodstream infections (BSI) at South African (SA)…”
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Microarray analysis of LTR retrotransposon silencing identifies Hdac1 as a regulator of retrotransposon expression in mouse embryonic stem cells
Published in PLoS computational biology (01-04-2012)“…Retrotransposons are highly prevalent in mammalian genomes due to their ability to amplify in pluripotent cells or developing germ cells. Host mechanisms that…”
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Seneca on anger, mercy and sadistic homicide – in 100 words
Published in British journal of psychiatry (01-09-2016)Get full text
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Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes
Published in The Journal of cell biology (04-05-2020)“…Age-dependent oocyte aneuploidy, a major cause of Down syndrome, is associated with declining sister chromatid cohesion in postnatal oocytes. Here we show that…”
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The Role of Chromatin Modifications in Progression through Mouse Meiotic Prophase
Published in Journal of genetics and genomics (20-03-2014)“…Meiosis is a key event in gametogenesis that generates new combinations of genetic information and is required to reduce the chro- mosome content of the…”
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An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning
Published in eLife (24-01-2019)“…Male germ cells of all placental mammals express an ancient nuclear RNA binding protein of unknown function called RBMXL2. Here we find that deletion of the…”
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Oocyte development, meiosis and aneuploidy
Published in Seminars in cell & developmental biology (01-09-2015)“…Meiosis is one of the defining events in gametogenesis. Male and female germ cells both undergo one round of meiotic cell division during their development in…”
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A review of published independent inquiries in England into psychiatric patient homicide, 1995-2010
Published in The journal of forensic psychiatry & psychology (01-12-2011)“…From 1994, individuals in England who are or who have recently been patients of mental health services and who have committed homicide should have their cases…”
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Practical system approaches to realise the human rights to water and sanitation: results and lessons from Uganda and Cambodia
Published in H2Open journal (01-01-2022)“…Abstract The United Nations General Assembly's 2010 legal recognition of the human rights to water and sanitation shaped approaches of many actors working to…”
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Defining high, medium, and low security in forensic mental healthcare: the development of the Matrix of Security in Scotland
Published in The journal of forensic psychiatry & psychology (01-06-2009)“…As differing levels of security in forensic mental healthcare have evolved, there has been no clear or concise agreed definition of high, medium, or low secure…”
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Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3
Published in Nature structural & molecular biology (01-02-2023)“…In meiosis, a supramolecular protein structure, the synaptonemal complex (SC), assembles between homologous chromosomes to facilitate their recombination…”
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Adaptation, Successful and Unsuccessful
Published in Postgraduate medical journal (01-03-2016)Get full text
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Cicero's description of mental disorder – 100 words
Published in British journal of psychiatry (01-07-2016)Get full text
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The challenge of preventing spree killings
Published in BMJ (Online) (19-12-2012)“…We know something about who perpetrates them and why, but not how to prevent them…”
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From Greek tragedy to a psychiatry lexicon
Published in British journal of psychiatry (01-03-2016)Get full text
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Computational Tools for the Analysis of Meiotic Prophase I Images
Published in Methods in molecular biology (Clifton, N.J.) (2024)“…Prophase I is a remarkable stage of meiotic division during which homologous chromosomes pair together and exchange DNA by meiotic recombination. Fluorescence…”
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