Search Results - "Crişan, Tania O."

Asymptomatic hyperuricaemia: a silent activator of the innate immune system by Joosten, Leo A. B., Crişan, Tania O., Bjornstad, Petter, Johnson, Richard J.

“…Asymptomatic hyperuricaemia affects ~20% of the general population in the USA, with variable rates in other countries. Historically, asymptomatic…”
Get full text

Urate‐induced immune programming: Consequences for gouty arthritis and hyperuricemia by Cabău, Georgiana, Crișan, Tania O., Klück, Viola, Popp, Radu A., Joosten, Leo A. B.

“…Trained immunity is a process in which innate immune cells undergo functional reprogramming in response to pathogens or damage‐associated molecules leading to…”
Get full text

Uric acid priming in human monocytes is driven by the AKT–PRAS40 autophagy pathway by Crişan, Tania O., Cleophas, Maartje C. P., Novakovic, Boris, Erler, Kathrin, van de Veerdonk, Frank L., Stunnenberg, Hendrik G., Netea, Mihai G., Dinarello, Charles A., Joosten, Leo A. B.

“…Metabolic triggers are important inducers of the inflammatory processes in gout. Whereas the high serum urate levels observed in patients with gout predispose…”
Get full text

GWAS-identified hyperuricemia-associated IGF1R variant rs6598541 has a limited role in urate mediated inflammation in human mononuclear cells by Gaal, Orsolya I., Liu, Ruiqi, Marginean, Dragoș, Badii, Medeea, Cabău, Georgiana, Hotea, Ioana, Nica, Valentin, Colcear, Doina, Pamfil, Cristina, Merriman, Tony R., Rednic, Simona, Popp, Radu A., Crișan, Tania O., Joosten, Leo A. B.

“…Gout is a common autoinflammatory joint diseases characterized by deposition of monosodium urate (MSU) crystals which trigger an innate immune response…”
Get full text

Innate immune memory: Implications for host responses to damage‐associated molecular patterns by Crișan, Tania O., Netea, Mihai G., Joosten, Leo A. B.

“…Cells of the innate immune system build immunological memory via epigenetic reprogramming after stimulations with microbial ligands. This functional…”
Get full text

Inflammasome-independent modulation of cytokine response by autophagy in human cells by Crişan, Tania O, Plantinga, Theo S, van de Veerdonk, Frank L, Farcaş, Marius F, Stoffels, Monique, Kullberg, Bart-Jan, van der Meer, Jos W M, Joosten, Leo A B, Netea, Mihai G

“…Autophagy is a cell housekeeping mechanism that has recently received attention in relation to its effects on the immune response. Genetic studies have…”
Get full text

Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases by Cleophas, Maartje C P, Crişan, Tania O, Lemmers, Heidi, Toenhake-Dijkstra, Helga, Fossati, Gianluca, Jansen, Tim L, Dinarello, Charles A, Netea, Mihai G, Joosten, Leo A B

“…Acute gouty arthritis is caused by endogenously formed monosodium urate (MSU) crystals, which are potent activators of the NLRP3 inflammasome. However, to…”
Get more information

Trained immunity and inflammation in rheumatic diseases by Badii, Medeea, Gaal, Orsolya, Popp, Radu A., Crișan, Tania O., Joosten, Leo A.B.

“…•Innate immune cells can mount an immunological memory called trained immunity.•Long-term innate immune adaptations occur via epigenetic and metabolic…”
Get full text

Immune Profiling of Patients with Systemic Sclerosis through Targeted Proteomic Analysis by Szabo, Iulia, Badii, Medeea, Gaál, Ildikó O, Szabo, Robert, Sîrbe, Claudia, Humiță, Oana, Joosten, Leo A B, Crișan, Tania O, Rednic, Simona

“…High-throughput proteomic analysis could offer new insights into the pathogenesis of systemic sclerosis (SSc) and reveal non-invasive biomarkers for diagnosis…”
Get full text

Enhanced Innate and Acquired Immune Responses in Systemic Sclerosis Primary Peripheral Blood Mononuclear Cells (PBMCs) by Szabo, Iulia, Badii, Medeea, Gaál, Ildikó O., Szabo, Robert, Popp, Radu A., Joosten, Leo A. B., Crişan, Tania O., Rednic, Simona

“…Chronic immune activation in systemic sclerosis is supported by the production of a plethora of cytokines with proven regulatory activities of the immune…”
Get full text

The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies by Leask, Megan P., Crișan, Tania O., Ji, Aichang, Matsuo, Hirotaka, Köttgen, Anna, Merriman, Tony R.

“…The pathogenesis of gout involves a series of steps beginning with hyperuricaemia, followed by the deposition of monosodium urate crystal in articular…”
Get full text

Soluble urate-induced effects on cytokine production in vitro - Assessment of methodologies and cell types by Liu, Ruiqi, Klück, Viola, Kischkel, Brenda, Tercan, Helin, Netea, Mihai G, Crişan, Tania O, Joosten, Leo A B

“…Hyperuricemia has been shown to be an inducer of pro-inflammatory mediators by human primary monocytes. To study the deleterious effects of hyperuricemia, a…”
Get full text

Detection of Novel Biomarkers in Pediatric Autoimmune Hepatitis by Proteomic Profiling by Sîrbe, Claudia, Badii, Medeea, Crişan, Tania O, Bența, Gabriel, Grama, Alina, Joosten, Leo A B, Rednic, Simona, Pop, Tudor Lucian

“…Autoimmune hepatitis (AIH) is characterized by immune-mediated hepatocyte injury resulting in the destruction of liver cells, causing inflammation, liver…”
Get full text

TGF-β is elevated in hyperuricemic individuals and mediates urate-induced hyperinflammatory phenotype in human mononuclear cells by Klück, Viola, Cabău, Georgiana, Mies, Linda, Bukkems, Femke, van Emst, Liesbeth, Bakker, René, van Caam, Arjan, Crişan, Tania O, Joosten, Leo A B

“…Soluble urate leads to a pro-inflammatory phenotype in human monocytes characterized by increased production of IL-1β and downregulation of IL-1 receptor…”
Get full text

Factors modulating the inflammatory response in acute gouty arthritis by Cleophas, Maartje C, Crişan, Tania O, Joosten, Leo A.B

“…PURPOSE OF REVIEWGout is a common debilitating form of arthritis and despite our extensive knowledge on the pathogenesis its prevalence is still rising…”
Get full text

Downregulation of type I interferon signalling pathway by urate in primary human PBMCs by Badii, Medeea, Nica, Valentin, Straton, Ancuța R, Kischkel, Brenda, Gaal, Orsolya, Cabău, Georgiana, Klück, Viola, Hotea, Ioana, Novakovic, Boris, Pamfil, Cristina, Rednic, Simona, Netea, Mihai G, Popp, Radu A, Joosten, Leo A B, Crișan, Tania O

“…Type I interferons (IFN1s) mediate innate responses to microbial stimuli and regulate interleukin (IL)-1 and IL-1 receptor antagonist (Ra) production in human…”
Get full text

Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout by Klück, Viola, van Deuren, Rosanne C, Cavalli, Giulio, Shaukat, Amara, Arts, Peer, Cleophas, Maartje C, Crișan, Tania O, Tausche, Anne-Kathrin, Riches, Philip, Dalbeth, Nicola, Stamp, Lisa K, Hindmarsh, Jennie Harré, Jansen, Tim L Th A, Janssen, Matthijs, Steehouwer, Marloes, Lelieveld, Stefan, van de Vorst, Maartje, Gilissen, Christian, Dagna, Lorenzo, Van de Veerdonk, Frank L, Eisenmesser, Elan Z, Kim, SooHyun, Merriman, Tony R, Hoischen, Alexander, Netea, Mihai G, Dinarello, Charles A, Joosten, Leo Ab

“…Gout is characterised by severe interleukin (IL)-1-mediated joint inflammation induced by monosodium urate crystals. Since IL-37 is a pivotal anti-inflammatory…”
Get more information

A functional genomics approach reveals suggestive quantitative trait loci associated with combined TLR4 and BCP crystal-induced inflammation and osteoarthritis by Klück, Viola, Boahen, Collins K., Kischkel, Brenda, Dos Santos, Jéssica C., Matzaraki, Vasiliki, Boer, Cindy G., van Meurs, Joyce B.J., Schraa, Kiki, Lemmers, Heidi, Dijkstra, Helga, Leask, Megan P., Merriman, Tony R., Crişan, Tania O., McCarthy, Geraldine M., Kumar, Vinod, Joosten, Leo A.B.

“…Basic calcium phosphate (BCP) crystals can activate the NLRP3 inflammasome and are potentially involved in the pathogenesis of osteoarthritis (OA). In order to…”
Get full text

Regulation of SOCS3-STAT3 in urate-induced cytokine production in human myeloid cells by Badii, Medeea, Klück, Viola, Gaal, Orsolya, Cabău, Georgiana, Hotea, Ioana, Nica, Valentin, Mirea, Andreea M., Bojan, Anca, Zdrenghea, Mihnea, Novakovic, Boris, Merriman, Tony R., Liu, Zhaoli, Li, Yang, Xu, Cheng-Jian, Pamfil, Cristina, Rednic, Simona, Popp, Radu A., Crişan, Tania O., Joosten, Leo A.B.

“…•Urate-primed PBMCs of hyperuricemic and gout patients show dysregulated cytokine production.•SOCS3 is enhanced in urate-primed myeloid cells, and this is…”
Get full text

Hyperuricemia remodels the serum proteome toward a higher inflammatory state by Cabău, Georgiana, Gaal, Orsolya, Badii, Medeea, Nica, Valentin, Mirea, Andreea-Manuela, Hotea, Ioana, Pamfil, Cristina, Popp, Radu A., Netea, Mihai G., Rednic, Simona, Crișan, Tania O., Joosten, Leo A.B.

“…Gout is an autoinflammatory disease triggered by a complex innate immune response to MSU crystals and inflammatory triggers. While hyperuricemia is an…”
Get full text