Search Results - "Crews, David"
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Minireview: Endocrine Disruptors: Past Lessons and Future Directions
Published in Molecular endocrinology (Baltimore, Md.) (01-08-2016)“…Within the past few decades, the concept of endocrine-disrupting chemicals (EDCs) has risen from a position of total obscurity to become a focus of dialogue,…”
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Temperature Shift Alters DNA Methylation and Histone Modification Patterns in Gonadal Aromatase (cyp19a1) Gene in Species with Temperature-Dependent Sex Determination
Published in PloS one (30-11-2016)“…The environment surrounding the embryos has a profound impact on the developmental process and phenotypic outcomes of the organism. In species with…”
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Epigenetic control of gonadal aromatase (cyp19a1) in temperature-dependent sex determination of red-eared slider turtles
Published in PloS one (07-06-2013)“…In the red-eared slider turtle (Trachemys scripta), a species with temperature-dependent sex determination (TSD), the expression of the aromatase gene during…”
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Epigenetic transgenerational inheritance of altered stress responses
Published in Proceedings of the National Academy of Sciences - PNAS (05-06-2012)“…Ancestral environmental exposures have previously been shown to promote epigenetic transgenerational inheritance and influence all aspects of an individual's…”
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Epigenetics, Evolution, Endocrine Disruption, Health, and Disease
Published in Endocrinology (Philadelphia) (01-06-2006)“…Endocrine-disrupting chemicals (EDCs) in the environment have been linked to human health and disease. This is particularly evident in compounds that mimic the…”
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Embryonic PCB Exposure Alters Phenotypic, Genetic, and Epigenetic Profiles in Turtle Sex Determination, a Biomarker of Environmental Contamination
Published in Endocrinology (Philadelphia) (01-11-2014)“…In species with temperature-dependent sex determination, embryonic gonadal differentiation can be modified by exposure to exogenous chemicals such as…”
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Passing experiences on to future generations: endocrine disruptors and transgenerational inheritance of epimutations in brain and sperm
Published in Epigenetics (02-11-2018)“…All animals have body burdens of polychlorinated biphenyls (PCBs) despite their ban decades ago. These and modern endocrine-disrupting chemicals (EDCs) such as…”
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The relation between liver damage and reproduction in female Japanese quail (Coturnix japonica) exposed to high ambient temperature
Published in Poultry science (01-09-2020)“…Reproductive failure associated with heat stress is a well-known phenomenon in poultry. High temperatures also induce various metabolic disturbances in many…”
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Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling
Published in Science (American Association for the Advancement of Science) (19-09-2003)“…Receptors for sex and adrenal steroid hormones are absent from fully sequenced invertebrate genomes and have not been recovered from other invertebrates. Here…”
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double-blind, placebo-controlled, randomized trial of the effects of dark chocolate and cocoa on variables associated with neuropsychological functioning and cardiovascular health: clinical findings from a sample of healthy, cognitively intact older adults
Published in The American journal of clinical nutrition (01-04-2008)“…BACKGROUND: In recent years, there has been increased interest in the potential health-related benefits of antioxidant- and phytochemical-rich dark chocolate…”
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Transgenerational epigenetic programming of the brain transcriptome and anxiety behavior
Published in PloS one (18-11-2008)“…Embryonic exposure to the endocrine disruptor vinclozolin during gonadal sex determination promotes an epigenetic reprogramming of the male germ-line that is…”
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Transgenerational epigenetic imprints on mate preference
Published in Proceedings of the National Academy of Sciences - PNAS (03-04-2007)“…Environmental contamination by endocrine-disrupting chemicals (EDC) can have epigenetic effects (by DNA methylation) on the germ line and promote disease…”
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Sexually Dimorphic Effects of Ancestral Exposure to Vinclozolin on Stress Reactivity in Rats
Published in Endocrinology (Philadelphia) (01-10-2014)“…How an individual responds to the environment depends upon both personal life history as well as inherited genetic and epigenetic factors from ancestors. Using…”
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The effects of prenatal PCBs on adult social behavior in rats
Published in Hormones and behavior (01-07-2015)“…Endocrine disrupting chemical (EDC) exposures during critical periods of development may influence neuronal development and the manifestation of sexually…”
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A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract EGb 761® in a sample of cognitively intact older adults: neuropsychological findings
Published in Human psychopharmacology (01-08-2002)“…There appears to be an absence of large‐scaled clinical trials that have examined the efficacy of Ginkgo biloba extract on the neuropsychological functioning…”
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Regulation of Pseudosexual Behavior in the Parthenogenetic Whiptail Lizard, Cnemidophorus uniparens
Published in Endocrinology (Philadelphia) (01-09-2008)“…Neuroendocrine mechanisms underlying complementary behaviors like male-typical mounting and female-typical receptivity are most often studied independently in…”
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Genetic network underlying temperature‐dependent sex determination is endogenously regulated by temperature in isolated cultured Trachemys scripta gonads
Published in Developmental dynamics (01-04-2010)“…In reptiles with temperature‐dependent sex determination, gonadogenesis is initially directed by the incubation temperature of the egg during the middle third…”
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Sex determination: where environment and genetics meet
Published in Evolution & development (01-01-2003)“…SUMMARY In mammals and birds the genetic constitution established at the time of fertilization determines the type of gonad that develops, whereas in all…”
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Identification of a Third Distinct Estrogen Receptor and Reclassification of Estrogen Receptors in Teleosts
Published in Proceedings of the National Academy of Sciences - PNAS (26-09-2000)“…This paper describes three distinct estrogen receptor (ER) subtypes: ERα , ERβ , and a unique type, ERγ , cloned from a teleost fish, the Atlantic croaker…”
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Two Hits of EDCs Three Generations Apart: Effects on Social Behaviors in Rats, and Analysis by Machine Learning
Published in Toxics (Basel) (11-01-2022)“…All individuals are directly exposed to extant environmental endocrine-disrupting chemicals (EDCs), and indirectly exposed through transgenerational…”
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