Search Results - "Creutzenberg, Otto"

The carcinogenic effect of various multi-walled carbon nanotubes (MWCNTs) after intraperitoneal injection in rats by Rittinghausen, Susanne, Hackbarth, Anja, Creutzenberg, Otto, Ernst, Heinrich, Heinrich, Uwe, Leonhardt, Albrecht, Schaudien, Dirk

“…Biological effects of tailor-made multi-walled carbon nanotubes (MWCNTs) without functionalization were investigated in vivo in a two-year carcinogenicity…”
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Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study by Ebmeyer, Johanna, Rasinger, Josef Daniel, Hengstler, Jan G., Schaudien, Dirk, Creutzenberg, Otto, Lampen, Alfonso, Braeuning, Albert, Hessel-Pras, Stefanie

“…Pyrrolizidine alkaloids (PA) are secondary plant metabolites that occur as food and feed contaminants. Acute and subacute PA poisoning can lead to severe liver…”
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Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats by Schwotzer, Daniela, Ernst, Heinrich, Schaudien, Dirk, Kock, Heiko, Pohlmann, Gerhard, Dasenbrock, Clemens, Creutzenberg, Otto

“…Nanomaterials like cerium oxide and barium sulfate are frequently processed in industrial and consumer products and exposure of humans and other organisms is…”
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Relative oral bioavailability of 3-MCPD from 3-MCPD fatty acid esters in rats by Abraham, Klaus, Appel, Klaus E., Berger-Preiss, Edith, Apel, Elisabeth, Gerling, Susanne, Mielke, Hans, Creutzenberg, Otto, Lampen, Alfonso

“…In order to quantify the relative oral bioavailability of 3-chloropropane-1,2-diol (3-MCPD) from 3-MCPD fatty acid diesters in vivo,…”
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Nanomaterials: certain aspects of application, risk assessment and risk communication by Laux, Peter, Tentschert, Jutta, Riebeling, Christian, Braeuning, Albert, Creutzenberg, Otto, Epp, Astrid, Fessard, Valérie, Haas, Karl-Heinz, Haase, Andrea, Hund-Rinke, Kerstin, Jakubowski, Norbert, Kearns, Peter, Lampen, Alfonso, Rauscher, Hubert, Schoonjans, Reinhilde, Störmer, Angela, Thielmann, Axel, Mühle, Uwe, Luch, Andreas

“…Development and market introduction of new nanomaterials trigger the need for an adequate risk assessment of such products alongside suitable risk…”
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Toxicokinetics of Nanoparticles Deposited in Lungs Using Occupational Exposure Scenarios by Creutzenberg, Otto, Pohlmann, Gerhard, Schaudien, Dirk, Kock, Heiko

“…Various synthetic powders with primary particle sizes at the nanoscale and a high commercial impact have been studied using Wistar rats. The test materials…”
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Toxicokinetic study following intratracheal instillation or oral gavage of two [7Be]-tagged carbon black samples by Creutzenberg, Otto, Hammann, Volker, Wolf, Stefanie, Daul, Jürgen, Ngiewih, Yufanyi, Chaudhuri, Ishrat, Levy, Len

“…Abstract Background The toxicokinetic behaviour of nanostructured particles following pulmonary or oral deposition is of great scientific interest. In this…”
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Pyrrolizidine alkaloid-induced transcriptomic changes in rat lungs in a 28-day subacute feeding study by Buchmueller, Julia, Sprenger, Heike, Ebmeyer, Johanna, Rasinger, Josef Daniel, Creutzenberg, Otto, Schaudien, Dirk, Hengstler, Jan G., Guenther, Georgia, Braeuning, Albert, Hessel-Pras, Stefanie

“…Pyrrolizidine alkaloids (PAs) are secondary plant metabolites synthesized by a wide range of plants as protection against herbivores. These toxins are found…”
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Experimental Study on the Transport and Alteration Behavior of Aerosols From Low Density Powders for Acute Inhalation Toxicology Studies by Wessely, Benno, Stintz, Michael, Nolde, Juergen, Creutzenberg, Otto

“…Low density powders have a bulk density of less than 100 kg/m3 and are produced technically by flame pyrolysis of silicon tetrachloride (pyrogenic powders such…”
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Cerium oxide and barium sulfate nanoparticle inhalation affects gene expression in alveolar epithelial cells type II by Schwotzer, Daniela, Niehof, Monika, Schaudien, Dirk, Kock, Heiko, Hansen, Tanja, Dasenbrock, Clemens, Creutzenberg, Otto

“…Understanding the molecular mechanisms of nanomaterial interacting with cellular systems is important for appropriate risk assessment. The identification of…”
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Relative oral bioavailability of glycidol from glycidyl fatty acid esters in rats by Appel, Klaus E., Abraham, Klaus, Berger-Preiss, Edith, Hansen, Tanja, Apel, Elisabeth, Schuchardt, Sven, Vogt, Carla, Bakhiya, Nadiya, Creutzenberg, Otto, Lampen, Alfonso

“…In order to quantify the relative bioavailability of glycidol from glycidyl fatty acid esters in vivo, glycidyl palmitoyl ester and glycidol were orally…”
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The pulmonary toxicity of carboxylated or aminated multi-walled carbon nanotubes in mice is determined by the prior purification method by Taylor-Just, Alexia J, Ihrie, Mark D, Duke, Katherine S, Lee, Ho Young, You, Dorothy J, Hussain, Salik, Kodali, Vamsi K, Ziemann, Christina, Creutzenberg, Otto, Vulpoi, Adriana, Turcu, Flaviu, Potara, Monica, Todea, Milica, van den Brule, Sybille, Lison, Dominique, Bonner, James C

“…Inhalation of multi-walled carbon nanotubes (MWCNTs) poses a potential risk to human health. In order to safeguard workers and consumers, the toxic properties…”
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Femtosecond pulsed laser microscopy: a new tool to assess the in vitro delivered dose of carbon nanotubes in cell culture experiments by Lison, Dominique, Ibouraadaten, Saloua, van den Brule, Sybille, Todea, Milica, Vulpoi, Adriana, Turcu, Flaviu, Ziemann, Christina, Creutzenberg, Otto, Bonner, James C, Ameloot, Marcel, Bové, Hannelore

“…In vitro models are widely used in nanotoxicology. In these assays, a careful documentation of the fraction of nanomaterials that reaches the cells, i.e. the…”
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PLATOX: Integrated In Vitro/In Vivo Approach for Screening of Adverse Lung Effects of Graphene-Related 2D Nanomaterials by Creutzenberg, Otto, Oliveira, Helena, Farcal, Lucian, Schaudien, Dirk, Mendes, Ana, Menezes, Ana Catarina, Tischler, Tatjana, Burla, Sabina, Ziemann, Christina

“…Graphene-related two-dimensional nanomaterials possess very technically promising characteristics, but gaps exist regarding their potential adverse health…”
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Evaluation of immunohistochemical markers to detect the genotoxic mode of action of fine and ultrafine dusts in rat lungs by Rittinghausen, Susanne, Bellmann, Bernd, Creutzenberg, Otto, Ernst, Heinrich, Kolling, Angelika, Mangelsdorf, Inge, Kellner, Rupert, Beneke, Sascha, Ziemann, Christina

“…Abstract Data on local genotoxicity after particle exposure are crucial to resolve mechanistic aspects such as the impact of chronic inflammation, types of DNA…”
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Biokinetics of Nanomaterials: the Role of Biopersistence by Laux, Peter, Riebeling, Christian, Booth, Andy M, Brain, Joseph D, Brunner, Josephine, Cerrillo, Cristina, Creutzenberg, Otto, Estrela-Lopis, Irina, Gebel, Thomas, Johanson, Gunnar, Jungnickel, Harald, Kock, Heiko, Tentschert, Jutta, Tlili, Ahmed, Schäffer, Andreas, Sips, Adriënne J A M, Yokel, Robert A, Luch, Andreas

“…Nanotechnology risk management strategies and environmental regulations continue to rely on hazard and exposure assessment protocols developed for bulk…”
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Physical Obstruction of Nasal Cavities With Subsequent Asphyxia, Causes Lethality of Rats in an Acute Inhalation Study With Hydrophobic HMDZ Surface-Treated Synthetic Amorphous Silica (SAS) by Krueger, Nils, Weber, Klaus, Warfving, Nils, Vitali, Alex, Nolde, Jürgen, Schuster, Tobias B, Bruer, Gustav Gerd, Creutzenberg, Otto, Wessely, Benno, Stintz, Michael, Moise, Valerie, Kellert, Marco

“…The aim of the present study was to understand the mechanism of lethality associated with high dose inhalation of a low-density hydrophobic surface-treated SAS…”
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Pulmonary toxicity of printer toner following inhalation and intratracheal instillation by Morimoto, Yasuo, Oyabu, Takako, Horie, Masanori, Kambara, Tatsunori, Izumi, Hiroto, Kuroda, Etsushi, Creutzenberg, Otto, Bellmann, Bernd, Pohlmann, Gerhard, Schuchardt, Sven, Hansen, Tanja, Ernst, Heinrich

“…Abstract The pulmonary effects of a finished toner were evaluated in intratracheal instillation and inhalation studies, using toners with external additives…”
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Reply to the "Letter to the Editor" by Morfeld et al by Creutzenberg, Otto H., Bellmann, Bernd, Korolewitz, Regina, Koch, Wolfgang, Mangelsdorf, Inge, Tillmann, Thomas, Schaudien, Dirk

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Additives for reducing the toxicity of respirable crystalline silica. SILIFE project by Monfort, Eliseo, López-Lilao, Ana, Escrig, Alberto, Jesus Ibáñez, Maria, Bonvicini, Guliana, Creutzenberg, Otto, Ziemann, Christina

“…Prolonged inhalation of crystalline silica particles has long been known to cause lung inflammation and development of the granulomatous and a fibrogenic lung…”
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