Search Results - "Crestey, François"

Design, Synthesis, and Biological Evaluation of Erythrina Alkaloid Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists by Crestey, François, Jensen, Anders A, Borch, Morten, Andreasen, Jesper Tobias, Andersen, Jacob, Balle, Thomas, Kristensen, Jesper Langgaard

“…The synthesis of a new series of Erythrina alkaloid analogues and their pharmacological characterization at various nicotine acetylcholine receptor (nAChR)…”
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Expedite Protocol for Construction of Chiral Regioselectively N-Protected Monosubstituted Piperazine, 1,4-Diazepane, and 1,4-Diazocane Building Blocks by Crestey, François, Witt, Matthias, Jaroszewski, Jerzy W, Franzyk, Henrik

“…This paper describes the first study of solution-phase synthesis of chiral monosubstituted piperazine building blocks from nosylamide-activated aziridines. The…”
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Total synthesis of ascididemin via anionic cascade ring closure by Petersen, Ida Nymann, Crestey, François, Kristensen, Jesper Langgaard

“…A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45%…”
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Chemo- and Regioselective Functionalization of Nortrilobolide: Application for Semisynthesis of the Natural Product 2‑Acetoxytrilobolide by Doan, Nhu Thi Quynh, Crestey, François, Olsen, Carl Erik, Christensen, Søren Brøgger

“…The difference in reactivity of the hexaoxygenated natural product thapsigargin (1) and the pentaoxygenated nortrilobolide (3) was compared in order to develop…”
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Concise synthesis of thapsigargin from nortrilobolide by Crestey, François, Toma, Maddalena, Christensen, Søren Brøgger

“…[Display omitted] Herein, we describe an expedient synthesis of the hexaoxygenated guaianolide thapsigargin (1), a potent inhibitor of the sarco/endoplasmic…”
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A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE by Jepsen, Tue Heesgaard, Glibstrup, Emil, Crestey, François, Jensen, Anders A, Kristensen, Jesper Langgaard

“…We report an effective synthetic protocol to access [6,6]-bicyclic lactone moieties through a regio- and stereoselective intramolecular Mizoroki-Heck…”
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Trifunctionalization of the Purine Scaffold Using Mg and Zn Organometallic Intermediates by Zimdars, Silvia, Jourdin, Xavier Mollat du, Crestey, François, Carell, Thomas, Knochel, Paul

“…Starting from an appropriate 6-chloro-2-TMS-purine derivative, a regioselective functionalization of the purine scaffold was achieved successively at positions…”
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Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts by Crestey, François, Jensen, Anders A, Soerensen, Christian, Magnus, Charlotte Busk, Andreasen, Jesper T, Peters, Günther H. J, Kristensen, Jesper L

“…We describe the synthesis of tetrahydroisoquinolines and tetrahydroisoquinolinium salts together with their pharmacological properties at various nicotinic…”
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Concise synthesis of new bridged-nicotine analogues by Crestey, François, Hooyberghs, Geert, Kristensen, Jesper L.

“…This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired…”
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Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines by Crestey, François, Witt, Matthias, Frydenvang, Karla, Stærk, Dan, Jaroszewski, Jerzy W, Franzyk, Henrik

“…This paper describes the first study of nucleophilic ring-opening of nosylamide-activated aziridines under microwave irradiation conditions in solid-phase…”
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Radiosynthesis and preclinical evaluation of [11C]Cimbi‐701 – Towards the imaging of cerebral 5‐HT7 receptors by L 'Estrade, Elina T., Shalgunov, Vladimir, Edgar, Fraser G., Strebl‐Bantillo, Martin G., Xiong, Mengfei, Crestey, François, Neelamegam, Ramesh, Dyssegaard, Agnete, Lehel, Szabolcs, Erlandsson, Maria, Ohlsson, Tomas, Hooker, Jacob M., Knudsen, Gitte M., Herth, Matthias M., Hansen, Hanne D.

“…The serotonin 7 (5‐HT7) receptor is suggested to be involved in a broad variety of CNS disorders, but very few in vivo tools exist to study this important…”
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Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors by Petersen, Ida Nymann, Crestey, François, Jensen, Anders A, Indurthi, Dinesh C, Pedersen, Henrik, Andreasen, Jesper T, Balle, Thomas, Kristensen, Jesper L

“…Conformational restriction of the pyrrolidine nitrogen in nicotine by the introduction of an ethylene bridge provided a potent and selective antagonist of the…”
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Efficient loading of primary alcohols onto a solid phase using a trityl bromide linker by Crestey, François, Ottesen, Lars K., Jaroszewski, Jerzy W., Franzyk, Henrik

“…The Letter describes an improved, rapid and mild strategy for the loading of primary alcohols onto a polystyrene trityl resin via a highly reactive trityl…”
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Identification and Electrophysiological Evaluation of 2‑Methylbenzamide Derivatives as Nav1.1 Modulators by Crestey, François, Frederiksen, Kristen, Jensen, Henrik S, Dekermendjian, Kim, Larsen, Peter H, Bastlund, Jesper F, Lu, Dunguo, Liu, Henry, Yang, Charles R, Grunnet, Morten, Svenstrup, Niels

“…Voltage-gated sodium channels (Nav) are crucial to the initiation and propagation of action potentials (APs) in electrically excitable cells, and during the…”
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A new and efficient synthesis of 2-azatryptophans by Crestey, François, Collot, Valérie, Stiebing, Silvia, Rault, Sylvain

“…This paper describes a new and simple synthesis of 2-azatryptophans in five steps from 2-ethylaniline. This methodology allows to obtain either the amino acid…”
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Design and synthesis of a new indazole library: direct conversion of  N-methoxy- N-methylamides (Weinreb amides) to 3-keto and 3-formylindazoles by Crestey, François, Stiebing, Silvia, Legay, Rémi, Collot, Valérie, Rault, Sylvain

“…Nucleophilic addition of Grignard or lithiated reagents on the new Weinreb amides 3 and 4 afforded efficiently the corresponding ketones and allowed the design…”
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New practical access to 2-azatryptophans and dehydro derivatives via the Wittig–Horner reaction by Crestey, François, Collot, Valérie, Stiebing, Silvia, Lohier, Jean-François, Santos, Jana Sopkova-de Oliveira, Rault, Sylvain

“…The Wittig–Horner reaction of protected 3-formylindazoles 1 with (±)- N-(benzyloxycarbonyl)-α-phosphonoglycine trimethyl ester 2 has been developed as a new…”
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A small molecule activator of Nav1.1 channels increases fast‐spiking interneuron excitability and GABAergic transmission in vitro and has anti‐convulsive effects in vivo by Frederiksen, Kristen, Lu, Dunguo, Yang, Jinhui, Jensen, Henrik Sindal, Bastlund, Jesper Frank, Larsen, Peter Hjørringgaard, Liu, Henry, Crestey, François, Dekermendjian, Kim, Badolo, Lassina, Laursen, Morten, Hougaard, Charlotte, Yang, Charles, Svenstrup, Niels, Grunnet, Morten

“…Nav1.1 (SCN1A) channels primarily located in gamma‐aminobutyric acid (GABA)ergic fast‐spiking interneurons are pivotal for action potential generation and…”
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Direct Cu-mediated aromatic 18 F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging by García-Vázquez, Rocío, Battisti, Umberto M, Jørgensen, Jesper T, Shalgunov, Vladimir, Hvass, Lars, Stares, Daniel L, Petersen, Ida N, Crestey, François, Löffler, Andreas, Svatunek, Dennis, Kristensen, Jesper L, Mikula, Hannes, Kjaer, Andreas, Herth, Matthias M

“…Pretargeted imaging can be used to visualize and quantify slow-accumulating targeting vectors with short-lived radionuclides such as fluorine-18 - the most…”
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Direct Cu-mediated aromatic 18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging by García-Vázquez, Rocío, Battisti, Umberto M, Jørgensen, Jesper T, Shalgunov, Vladimir, Hvass, Lars, Stares, Daniel L, Petersen, Ida N, Crestey, François, Löffler, Andreas, Svatunek, Dennis, Kristensen, Jesper L, Mikula, Hannes, Kjaer, Andreas, Herth, Matthias M

“…Pretargeted imaging can be used to visualize and quantify slow-accumulating targeting vectors with short-lived radionuclides such as fluorine-18 – the most…”
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