Search Results - "Cresteil, T"

Annonaceae fruits and parkinsonism risk: Metabolisation study of annonacin, a model neurotoxin; evaluation of human exposure by Le Ven, J., Schmitz-Afonso, I., Touboul, D., Buisson, D., Akagah, B., Cresteil, T., Lewin, G., Champy, P.

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Oxidative Metabolism of Amprenavir in the Human Liver. Effect of the CYP3A Maturation by TRELUYER, J. M, BOWERS, G, CAZALI, N, SONNIER, M, REY, E, PONS, G, CRESTEIL, T

“…Amprenavir is a human immunodeficiency virus-1 (HIV-1) protease inhibitor intended to be used to treat HIV-infected children. Although a pediatric dosage is…”
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In vitro oxidative metabolism study of (−)-rhazinilam by Décor, Anne, Bellocq, Delphine, Thoison, Odile, Lekieffre, Nicolas, Chiaroni, Angèle, Ouazzani, Jamal, Cresteil, Thierry, Guéritte, Françoise, Baudoin, Olivier

“…Metabolism studies were conducted in order to investigate the reasons for the in vivo lack of activity of (−)-rhazinilam 1, an original poison of the mitotic…”
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Evidence of impaired cisapride metabolism in neonates by Tréluyer, Jean‐Marc, Rey, E, Sonnier, M., Pons, G, Cresteil, T

“…Aims  Cisapride has been shown to cause QTc prolongation in neonates in the absence of any of the known risk factors ascribed to children or adults (excessive…”
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A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities by Lawton, M P, Cashman, J R, Cresteil, T, Dolphin, C T, Elfarra, A A, Hines, R N, Hodgson, E, Kimura, T, Ozols, J, Phillips, I R

“…A nomenclature based on comparisons of amino acid sequences is proposed for the members of the mammalian flavin-containing monooxygenase (FMO) gene family…”
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Molecular Regulation of Genes Encoding Xenobiotic-Metabolizing Enzymes: Mechanisms Involving Endogenous Factors by HINES, R. N, LUO, Z, ELFERINK, C. J, CRESTEIL, T, DING, X, PROUGH, R. A, FITZPATRICK, J. L, RIPP, S. L, FALKNER, K. C, GE, N.-L, LEVINE, A

“…It is widely recognized that xenobiotic-metabolizing enzymes play a fundamental role in the basic processes of carcinogenesis and toxicity on one hand, and…”
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Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults by Cazeneuve, C., Pons, G., Rey, E., Treluyer, JM, Cresteil, T., Thiroux, G., D'Athis, P., Olive, G.

“…1. Caffeine metabolism was studied in human liver microsomes from foetuses (n = 10), neonates (n = 10), infants (n = 9) and adults (n = 5). Caffeine and its…”
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Anticancer copper(II) phosphorus dendrimers are potent proapoptotic Bax activators by Mignani, Serge, El Brahmi, Nabil, Eloy, Laure, Poupon, Joel, Nicolas, Valérie, Steinmetz, Anke, El Kazzouli, Said, Bousmina, Mosto M., Blanchard-Desce, Mireille, Caminade, Anne-Marie, Majoral, Jean-Pierre, Cresteil, Thierry

“…A multivalent phosphorus dendrimer 1G3 and its corresponding Cu-complex, 1G3-Cu have been recently identified as agents retaining high antiproliferative…”
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Contrôle génétique de la maturation du métabolisme des médicaments by Cresteil, T.

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Original Multivalent Gold(III) and Dual Gold(III)–Copper(II) Conjugated Phosphorus Dendrimers as Potent Antitumoral and Antimicrobial Agents by Mignani, Serge M, El Brahmi, Nabil, El Kazzouli, Saïd, Laurent, Regis, Ladeira, Sonia, Caminade, Anne-Marie, Pedziwiatr-Werbicka, Elzbieta, Szewczyk, Eligia M, Bryszewska, Maria, Bousmina, Mosto M, Cresteil, Thierry, Majoral, Jean-Pierre

“…Original metallophosphorus dendrimers (generation 3, 48 terminal groups) have been prepared via the complexation of phosphorus dendrimers bearing…”
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A novel class of ethacrynic acid derivatives as promising drug-like potent generation of anticancer agents with established mechanism of action by Mignani, Serge, El Brahmi, Nabil, El Kazzouli, Saïd, Eloy, Laure, Courilleau, Delphine, Caron, Joachim, Bousmina, Mosto M., Caminade, Anne-Marie, Cresteil, Thierry, Majoral, Jean-Pierre

“…The well-known diuretic Ethacrynic acid (EA, Edecrin), showing low anti-proliferative activities, was chemically modified at different positions. The new EA…”
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Semisynthesis of (+)- and (−)-goniomitine from (−)- and (+)-vincadifformine by Lewin, Guy, Bernadat, Guillaume, Aubert, Geneviève, Cresteil, Thierry

“…The first biomimetic semisynthesis of goniomitine has been accomplished in nine steps with 11% overall yield starting from vincadifformine. Natural (−)- and…”
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IN VITRO METABOLISM STUDY OF BUPRENORPHINE: EVIDENCE FOR NEW METABOLIC PATHWAYS by PICARD, Nicolas, CRESTEIL, Thierry, DJEBLI, Nassim, MARQUET, Pierre

“…Buprenorphine (BUP) is a synthetic derivative of the morphine alkaloid thebaine. BUP is metabolized by N -dealkylation to form the active metabolite…”
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Specific and enantioselective sulfoxidation of an aryl-trifluoromethyl sulfide by rat liver cytochromes P-450 by Benoit, E, Cresteil, T, Riviere, J L, Delatour, P

“…Evidence based on thermal stability and enzyme inhibition data suggests that the sulfoxidation of the drug toltrazuril by rat liver microsomes is catalyzed by…”
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Cytochrome P-450 isoenzyme content and monooxygenase activities in rat liver: effect of ontogenesis and pretreatment by phenobarbital and 3-methylcholanthrene by Cresteil, T, Beaune, P, Celier, C, Leroux, J P, Guengerich, F P

“…The overall cytochrome P-450 content and the immunochemically determined concentrations of constitutive isoenzymes UT-A and UT-I and isoenzymes induced by…”
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Metabolism of sanguinarine in human and in rat: Characterization of oxidative metabolites produced by human CYP1A1 and CYP1A2 and rat liver microsomes using liquid chromatography–tandem mass spectrometry by Deroussent, Alain, Ré, Micheline, Hoellinger, Henri, Cresteil, Thierry

“…The quaternary benzo[ c]phenanthridine alkaloid, sanguinarine (SA), has been detected in the mustard oil contaminated with Argemone mexicana, which produced…”
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Hormonal regulation of microsomal flavin-containing monooxygenase: tissue-dependent expression and substrate specificity by Lemoine, A, Williams, D E, Cresteil, T, Leroux, J P

“…The substrate- and tissue-dependent hormonal regulation of flavin-containing monooxygenase (EC 1.14.13.8) was studied in male and female rats. Hypophysectomy…”
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Antiangiogenic activity of neutral lipids, glycolipids, and phospholipids fractions of Pinus halepensis Mill. seeds by Kadri, Nabil, Khettal, Bachra, Adjebli, Ahmed, Cresteil, Thierry, Yahiaoui-Zaidi, Rachida, Barragan-Montero, Veronique, Montero, Jean-Louis

“…•Lipid fractions (neutral lipids, glycolipids and phospholipids) of Pinus halepensis Mill. seeds were complexed by β-Cyclodextrin.•No cytotoxicity effect was…”
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Bioactive indole derivatives from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp by Longeon, Arlette, Copp, Brent R, Quévrain, Elodie, Roué, Mélanie, Kientz, Betty, Cresteil, Thierry, Petek, Sylvain, Debitus, Cécile, Bourguet-Kondracki, Marie-Lise

“…Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were…”
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CYP3A5 mRNA degradation by nonsense-mediated mRNA decay by Busi, Florent, Cresteil, Thierry

“…The total CYP3A5 mRNA level is significantly greater in carriers of the CYP3A5*1 allele than in CYP3A5*3 homozygotes. Most of the CYP3A5*3 mRNA includes an…”
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