Search Results - "Cress, W. Douglas"

cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth by Chen, Zirong, Li, Jian-Liang, Lin, Shuibin, Cao, Chunxia, Gimbrone, Nicholas T, Yang, Rongqiang, Fu, Dongtao A, Carper, Miranda B, Haura, Eric B, Schabath, Matthew B, Lu, Jianrong, Amelio, Antonio L, Cress, W Douglas, Kaye, Frederic J, Wu, Lizi

“…The LKB1 tumor suppressor gene is frequently mutated and inactivated in non-small cell lung cancer (NSCLC). Loss of LKB1 promotes cancer progression and…”
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Trim28 contributes to EMT via regulation of E-cadherin and N-cadherin in lung cancer cell lines by Chen, Lu, Muñoz-Antonia, Teresita, Cress, W Douglas

“…In previous work, we demonstrated that transcription factor Trim28 (Tripartite motif containing 28) plays a tumor-suppressor role in early-staged…”
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TGF-β—inducible microRNA-183 silences tumor-associated natural killer cells by Donatelli, Sarah S., Zhou, Jun-Min, Gilvary, Danielle L., Eksioglu, Erika A., Chen, Xianghong, Cress, W. Douglas, Haura, Eric B., Schabath, Matthew B., Coppola, Domenico, Wei, Sheng, Djeu, Julie Y.

“…Transforming growth factor β1 (TGF-β), enriched in the tumor microenvironment and broadly immunosuppressive, inhibits natural killer (NK) cell function by…”
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E2F inhibition synergizes with paclitaxel in lung cancer cell lines by Kurtyka, Courtney A, Chen, Lu, Cress, W Douglas

“…The CDK/Rb/E2F pathway is commonly disrupted in lung cancer, and thus, it is predicted that blocking the E2F pathway would have therapeutic potential. To test…”
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Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage by Chen, Jiandong, Wang, Chuangui, Chen, Lihong, Hou, Xinghua, Li, Zhenyu, Kabra, Neha, Ma, Yihong, Nemoto, Shino, Finkel, Toren, Gu, Wei, Cress, W. Douglas

“…The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase Sir2 (silent information regulator 2) regulates gene silencing in yeast and promotes lifespan…”
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Prognostic and Predictive Value of a Malignancy-Risk Gene Signature in Early-Stage Non-Small Cell Lung Cancer by Chen, Dung-Tsa, Hsu, Ying-Lin, Fulp, William J., Coppola, Domenico, Haura, Eric B., Yeatman, Timothy J., Cress, W. Douglas

“…Background The malignancy-risk gene signature is composed of numerous proliferative genes and has been applied to predict breast cancer risk. We hypothesized…”
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CDK4/6 inhibition synergizes with inhibition of P21-Activated Kinases (PAKs) in lung cancer cell lines by Wright, Gabriela M, Gimbrone, Nick T, Sarcar, Bhaswati, Percy, Trent R, Gordián, Edna R, Kinose, Fumi, Sumi, Natália J, Rix, Uwe, Cress, W. Douglas

“…Theoretically, small molecule CDK4/6 inhibitors (CDK4/6is) represent a logical therapeutic option in non-small cell lung cancers since most of these…”
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MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer by Xie, Mengyu, Zheng, Hong, Madan-Lala, Ranjna, Dai, Wenjie, Gimbrone, Nicholas T, Chen, Zhihua, Kinose, Fumi, Blackstone, Sarah A, Smalley, Keiran S M, Cress, W Douglas, Haura, Eric B, Rix, Uwe, Beg, Amer A

“…Activating mutations in BRAF, a key mediator of RAS signaling, are present in approximately 50% of melanoma patients. Pharmacologic inhibition of BRAF or the…”
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Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells by Brazelle, William, Kreahling, Jenny M, Gemmer, Jennifer, Ma, Yihong, Cress, W Douglas, Haura, Eric, Altiok, Soner

“…Histone deacetylase inhibitors (HDACis) are promising anticancer drugs; however, the molecular mechanisms leading to HDACi-induced cell death have not been…”
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Role of Stat3 in Regulating p53 Expression and Function by Niu, Guilian, Wright, Kenneth L., Ma, Yihong, Wright, Gabriela M., Huang, Mei, Irby, Rosalyn, Briggs, Jon, Karras, James, Cress, W. Douglas, Pardoll, Drew, Jove, Richard, Chen, Jiangdong, Yu, Hua

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Evaluating somatic tumor mutation detection without matched normal samples by Teer, Jamie K, Zhang, Yonghong, Chen, Lu, Welsh, Eric A, Cress, W Douglas, Eschrich, Steven A, Berglund, Anders E

“…Observations of recurrent somatic mutations in tumors have led to identification and definition of signaling and other pathways that are important for cancer…”
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Somatic Mutations and Ancestry Markers in Hispanic Lung Cancer Patients by Gimbrone, Nicholas T, Sarcar, Bhaswati, Gordian, Edna R, Rivera, Jason I, Lopez, Christian, Yoder, Sean J, Teer, Jamie K, Welsh, Eric A, Chiappori, Alberto A, Schabath, Matthew B, Reuther, Gary W, Dutil, Julie, Garcia, Miosotis, Ventosilla-Villanueva, Ronald, Vera-Valdivia, Luis, Yabar-Berrocal, Alejandro, Motta-Guerrero, Rodrigo, Santiago-Cardona, Pedro G, Muñoz-Antonia, Teresita, Cress, W Douglas

“…To address the lack of genomic data from Hispanic/Latino (H/L) patients with lung cancer, the Latino Lung Cancer Registry was established to collect patient…”
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A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma by Chen, Lu, Engel, Brienne E, Welsh, Eric A, Yoder, Sean J, Brantley, Stephen G, Chen, Dung-Tsa, Beg, Amer A, Cao, Chunxia, Kaye, Frederic J, Haura, Eric B, Schabath, Matthew B, Cress, W Douglas

“…Serine/threonine kinase 11 gene (STK11), better known as liver kinase β1, is a tumor suppressor that is commonly mutated in lung adenocarcinoma (LUAD)…”
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PAXIP1 Potentiates the Combination of WEE1 Inhibitor AZD1775 and Platinum Agents in Lung Cancer by Jhuraney, Ankita, Woods, Nicholas T, Wright, Gabriela, Rix, Lily, Kinose, Fumi, Kroeger, Jodi L, Remily-Wood, Elizabeth, Cress, W Douglas, Koomen, John M, Brantley, Stephen G, Gray, Jhanelle E, Haura, Eric B, Rix, Uwe, Monteiro, Alvaro N

“…The DNA damage response (DDR) involves a complex network of signaling events mediated by modular protein domains such as the BRCA1 C-terminal (BRCT) domain…”
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E2F1: A new role in the DNA damage response by Cress, W. Douglas

“…Comment on: Jie Chen, et al. Cell Cycle 2011; 10:1287-94…”
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A small-molecule E2F inhibitor blocks growth in a melanoma culture model by Ma, Yihong, Kurtyka, Courtney A, Boyapalle, Sandhya, Sung, Shen-Shu, Lawrence, Harshani, Guida, Wayne, Cress, W Douglas

“…HLM006474 was identified using a computer-based virtual screen and the known crystal structure of the DNA-bound E2F4/DP2 heterodimer. Treatment of multiple…”
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Impact of upfront cellular enrichment by laser capture microdissection on protein and phosphoprotein drug target signaling activation measurements in human lung cancer: Implications for personalized medicine by Baldelli, Elisa, Haura, Eric B., Crinò, Lucio, Cress, Douglas W., Ludovini, Vienna, Schabath, Matthew B., Liotta, Lance A., Petricoin, Emanuel F., Pierobon, Mariaelena

“…Purpose The aim of this study was to evaluate whether upfront cellular enrichment via laser capture microdissection (LCM) is necessary for accurately…”
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CX3CR1 deficiency-induced TIL tumor restriction as a novel addition for CAR-T design in solid malignancies by Trinh, ThuLe, Adams, William A., Calescibetta, Alexandra, Tu, Nhan, Dalton, Robert, So, Tina, Wei, Max, Ward, Grace, Kostenko, Elena, Christiansen, Sean, Cen, Ling, McLemore, Amy, Reed, Kayla, Whitting, Junmin, Gilvary, Danielle, Blanco, Neale Lopez, Segura, Carlos Moran, Nguyen, Jonathan, Kandell, Wendy, Chen, Xianghong, Cheng, Pingyan, Wright, Gabriela M., Cress, W. Douglas, Liu, Jinghong, Wright, Kenneth L., Wei, Sheng, Eksioglu, Erika A.

“…Advances in the understanding of the tumor microenvironment have led to development of immunotherapeutic strategies, such as chimeric antigen receptor T cells…”
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Regulation of E2F1 Function by the Nuclear Corepressor KAP1 by Wang, Chuangui, Rauscher, Frank J., Cress, W. Douglas, Chen, Jiandong

“…KAP1 is a nuclear corepressor with conserved domains for RING finger, B boxes, leucine zipper α helical coiled-coil region, plant homeo domain finger, and…”
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Grading of lung adenocarcinomas with simultaneous segmentation by artificial intelligence (GLASS-AI) by Lockhart, John H., Ackerman, Hayley D., Lee, Kyubum, Abdalah, Mahmoud, Davis, Andrew John, Hackel, Nicole, Boyle, Theresa A., Saller, James, Keske, Aysenur, Hänggi, Kay, Ruffell, Brian, Stringfield, Olya, Cress, W. Douglas, Tan, Aik Choon, Flores, Elsa R.

“…Preclinical genetically engineered mouse models (GEMMs) of lung adenocarcinoma are invaluable for investigating molecular drivers of tumor formation,…”
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