Search Results - "Crespo‐Garcia, Sergio"

Myeloid‐resident neuropilin‐1 promotes choroidal neovascularization while mitigating inflammation by Andriessen, Elisabeth M M A, Binet, François, Fournier, Frédérik, Hata, Masayuki, Dejda, Agnieszka, Mawambo, Gaëlle, Crespo‐Garcia, Sergio, Pilon, Frédérique, Buscarlet, Manuel, Beauchemin, Karine, Bougie, Véronique, Cumberlidge, Garth, Wilson, Ariel M, Bourgault, Steve, Rezende, Flavio A, Beaulieu, Normand, Delisle, Jean‐Sébastien, Sapieha, Przemyslaw

“…Age‐related macular degeneration (AMD) in its various forms is a leading cause of blindness in industrialized countries. Here, we provide evidence that ligands…”
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Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy by Binet, François, Cagnone, Gael, Crespo-Garcia, Sergio, Hata, Masayuki, Neault, Mathieu, Dejda, Agnieszka, Wilson, Ariel M., Buscarlet, Manuel, Mawambo, Gaelle Tagne, Howard, Joel P., Diaz-Marin, Roberto, Parinot, Celia, Guber, Vera, Pilon, Frédérique, Juneau, Rachel, Laflamme, Rémi, Sawchyn, Christina, Boulay, Karine, Leclerc, Severine, Abu-Thuraia, Afnan, Côté, Jean-François, Andelfinger, Gregor, Rezende, Flavio A., Sennlaub, Florian, Joyal, Jean-Sébastien, Mallette, Frédérick A., Sapieha, Przemyslaw

“…Remodeling senescent blood vessels The retina is a thin layer of nervous tissue at the back of the eye that transforms light into neuronal signals. The retina…”
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Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition by Crespo-Garcia, Sergio, Tsuruda, Pamela R., Dejda, Agnieszka, Ryan, Rathi D., Fournier, Frederik, Chaney, Shawnta Y., Pilon, Frederique, Dogan, Taner, Cagnone, Gael, Patel, Priyanka, Buscarlet, Manuel, Dasgupta, Sonali, Girouard, Gabrielle, Rao, Surabhi R., Wilson, Ariel M., O’Brien, Robert, Juneau, Rachel, Guber, Vera, Dubrac, Alexandre, Beausejour, Christian, Armstrong, Scott, Mallette, Frederick A., Yohn, Christopher B., Joyal, Jean-Sebastien, Marquess, Dan, Beltran, Pedro J., Sapieha, Przemyslaw

“…Attenuating pathological angiogenesis in diseases characterized by neovascularization such as diabetic retinopathy has transformed standards of care. Yet…”
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NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy by Miloudi, Khalil, Oubaha, Malika, Ménard, Catherine, Dejda, Agnieszka, Guber, Vera, Cagnone, Gael, Wilson, Ariel M., Tétreault, Nicolas, Mawambo, Gaëlle, Binet, Francois, Chidiac, Rony, Delisle, Chantal, Buscarlet, Manuel, Cerani, Agustin, Crespo-Garcia, Sergio, Bentley, Katie, Rezende, Flavio, Joyal, Jean-Sebastien, Mallette, Frédérick A., Gratton, Jean-Philippe, Larrivée, Bruno, Sapieha, Przemyslaw

“…Diabetic macular edema is a major complication of diabetes resulting in loss of central vision. Although heightened vessel leakiness has been linked to glial…”
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Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy by Crespo-Garcia, Sergio, Reichhart, Nadine, Kociok, Norbert, Skosyrski, Sergej, Joussen, Antonia M

“…Diabetic retinopathy is characterized by dysfunction of the retinal vascular network, combined with a persistent low-grade inflammation that leads to…”
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Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life by Hata, Masayuki, Hata, Maki, Andriessen, Elisabeth Mma, Juneau, Rachel, Pilon, Frédérique, Crespo-Garcia, Sergio, Diaz-Marin, Roberto, Guber, Vera, Binet, Francois, Fournier, Frédérik, Buscarlet, Manuel, Grou, Caroline, Calderon, Virginie, Heckel, Emilie, Melichar, Heather J, Joyal, Jean-Sebastien, Wilson, Ariel M, Sapieha, Przemyslaw

“…Pathological neovascularization in age-related macular degeneration (nvAMD) drives the principal cause of blindness in the elderly. While there is a robust…”
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An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models by Foddis, Marco, Winek, Katarzyna, Bentele, Kajetan, Mueller, Susanne, Blumenau, Sonja, Reichhart N, Nadine, Crespo-Garcia, Sergio, Harnett, Dermot, Ivanov, Andranik, Meisel, Andreas, Joussen, Antonia, Strauss, Olaf, Beule, Dieter, Dirnagl, Ulrich, Sassi, Celeste

“…Brain collateral circulation is an essential compensatory mechanism in response to acute brain ischemia. To study the temporal evolution of brain macro and…”
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Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity by Diaz-Marin, Roberto, Crespo-Garcia, Sergio, Wilson, Ariel M., Buscarlet, Manuel, Dejda, Agnieszka, Fournier, Frédérik, Juneau, Rachel, Alquier, Thierry, Sapieha, Przemyslaw

“…The beneficial effects of brown adipose tissue (BAT) on obesity and associated metabolic diseases are mediated through its capacity to dissipate energy as…”
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Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO) by Crespo-Garcia, Sergio, Reichhart, Nadine, Skosyrski, Sergej, Foddis, Marco, Wu, Jim, Figura, Aleksandar, Herrspiegel, Christina, Füchtemeier, Martina, Sassi, Celeste, Dirnagl, Ulrich, Joussen, Antonia M, Strauss, Olaf

“…Animal models of disease are an indispensable element in our quest to understand pathophysiology and develop novel therapies. Ex vivo studies have severe…”
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Anoctamin-4 is a bona fide Ca2+-dependent non-selective cation channel by Reichhart, Nadine, Schöberl, Simon, Keckeis, Susanne, Alfaar, Ahmad S., Roubeix, Christophe, Cordes, Magdalena, Crespo-Garcia, Sergio, Haeckel, Akvile, Kociok, Norbert, Föckler, Renate, Fels, Gabriele, Mataruga, Anja, Rauh, Robert, Milenkovic, Vladimir M., Zühlke, Kerstin, Klussmann, Enno, Schellenberger, Eyk, Strauß, Olaf

“…Changes in cell function occur by specific patterns of intracellular Ca 2+ , activating Ca 2+ -sensitive proteins. The anoctamin (TMEM16) protein family has Ca…”
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HIF1α-dependent hypoxia response in myeloid cells requires IRE1α by Mawambo, Gaëlle, Oubaha, Malika, Ichiyama, Yusuke, Blot, Guillaume, Crespo-Garcia, Sergio, Dejda, Agnieszka, Binet, François, Diaz-Marin, Roberto, Sawchyn, Christina, Sergeev, Mikhail, Juneau, Rachel, Kaufman, Randal J, Affar, El Bachir, Mallette, Frédérick A, Wilson, Ariel M, Sapieha, Przemyslaw

“…Cellular adaptation to low oxygen tension triggers primitive pathways that ensure proper cell function. Conditions of hypoxia and low glucose are…”
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Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration by Roubeix, Christophe, Nous, Caroline, Augustin, Sébastien, Ronning, Kaitryn E, Mathis, Thibaud, Blond, Frédéric, Lagouge-Roussey, Pauline, Crespo-Garcia, Sergio, Sullivan, Patrick M, Gautier, Emmanuel L, Reichhart, Nadine, Sahel, José-Alain, Burns, Marie E, Paques, Michel, Sørensen, Torben Lykke, Strauss, Olaf, Guillonneau, Xavier, Delarasse, Cécile, Sennlaub, Florian

“…Age-related macular degeneration (AMD) is invariably associated with the chronic accumulation of activated mononuclear phagocytes in the subretinal space. The…”
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Inhibition of Placenta Growth Factor Reduces Subretinal Mononuclear Phagocyte Accumulation in Choroidal Neovascularization by Crespo-Garcia, Sergio, Corkhill, Caitlin, Roubeix, Christophe, Davids, Anja-Maria, Kociok, Norbert, Strauss, Olaf, Joussen, Antonia M, Reichhart, Nadine

“…The cellular immune response driven by mononuclear phagocytes (MPs) is crucial for choroidal neovascularization (CNV) progression. Case reports show that a…”
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Myeloid cells contribute indirectly to VEGF expression upon hypoxia via activation of Müller cells by Nürnberg, Christina, Kociok, Norbert, Brockmann, Claudia, Lischke, Timo, Crespo-Garcia, Sergio, Reichhart, Nadine, Wolf, Susanne, Baumgrass, Ria, Eming, Sabine A., Beer-Hammer, Sandra, Joussen, Antonia M.

“…Anti-VEGF-directed therapies have been a milestone for treating retinal vascular diseases. Depletion of monocyte lineage cells suppresses pathological…”
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Correction: Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO) by Crespo-Garcia, Sergio, Reichhart, Nadine, Skosyrski, Sergej, Foddis, Marco, Wu, Jim, Figura, Aleksandar, Herrspiegel, Christina, Füchtemeier, Martina, Sassi, Celeste, Dirnagl, Ulrich, Joussen, Antonia M, Strauss, Olaf

“…[This corrects the article DOI: 10.1371/journal.pone.0193961.]…”
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Dataset on the activation of Müller cells through macrophages upon hypoxia in the retina by Nürnberg, Christina, Kociok, Norbert, Brockmann, Claudia, Lischke, Timo, Crespo-Garcia, Sergio, Reichhart, Nadine, Wolf, Susanne, Baumgrass, Ria, Eming, Sabine A., Beer-Hammer, Sandra, Joussen, Antonia M.

“…The dataset presented in this article complements the article entitled “Myeloid cells contribute indirectly to VEGF expression upon hypoxia via activation of…”
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Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation by Hata, Masayuki, Andriessen, Elisabeth M M A, Hata, Maki, Diaz-Marin, Roberto, Fournier, Frédérik, Crespo-Garcia, Sergio, Blot, Guillaume, Juneau, Rachel, Pilon, Frédérique, Dejda, Agnieszka, Guber, Vera, Heckel, Emilie, Daneault, Caroline, Calderon, Virginie, Des Rosiers, Christine, Melichar, Heather J, Langmann, Thomas, Joyal, Jean-Sebastien, Wilson, Ariel M, Sapieha, Przemyslaw

“…Age-related macular degeneration is a prevalent neuroinflammatory condition and a major cause of blindness driven by genetic and environmental factors such as…”
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Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis by Fournier, Frédérik, Diaz-Marin, Roberto, Pilon, Frédérique, Neault, Mathieu, Juneau, Rachel, Girouard, Gabrielle, Wilson, Ariel M, Larrivée, Bruno, Mallette, Frédérick A, Crespo-Garcia, Sergio, Sapieha, Przemyslaw

“…Obesity is a major risk factor for cancer. Conventional thought suggests that elevated adiposity predisposes to heightened inflammatory stress and potentiates…”
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Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results by Crespo-Garcia, Sergio, Fournier, Frédérik, Diaz-Marin, Roberto, Klier, Sharon, Ragusa, Derek, Masaki, Lauren, Cagnone, Gael, Blot, Guillaume, Hafiane, Ikhlas, Dejda, Agnieszka, Rizk, Rana, Juneau, Rachel, Buscarlet, Manuel, Chorfi, Sarah, Patel, Priyanka, Beltran, Pedro J., Joyal, Jean-Sebastien, Rezende, Flavio A., Hata, Masayuki, Nguyen, Alex, Sullivan, Lynne, Damiano, Jason, Wilson, Ariel M., Mallette, Frédérick A., David, Nathaniel E., Ghosh, Anirvan, Tsuruda, Pamela R., Dananberg, Jamie, Sapieha, Przemyslaw

“…Compromised vascular endothelial barrier function is a salient feature of diabetic complications such as sight-threatening diabetic macular edema (DME)…”
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HIF1[alpha]-dependent hypoxia response in myeloid cells requires IRE1[alpha] by Mawambo, Gaëlle, Oubaha, Malika, Ichiyama, Yusuke, Blot, Guillaume, Crespo-Garcia, Sergio, Dejda, Agnieszka, Binet, François, Diaz-Marin, Roberto, Sawchyn, Christina, Sergeev, Mikhail, Juneau, Rachel, Kaufman, Randal J, Affar, El Bachir, Mallette, Frédérick A, Wilson, Ariel M, Sapieha, Przemyslaw

“…Cellular adaptation to low oxygen tension triggers primitive pathways that ensure proper cell function. Conditions of hypoxia and low glucose are…”
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