4CPS-354 Efficacy and safety with erenumab and galcanezumab: our experience

Background and importanceCalcitonin gene related peptide (CGRP) receptor inhibitors are a new group of drugs that have been included for migraine pharmacotherapy and migraine prevention. Erenumab and galcanezumab have notable individual variance and we wanted to explore this effect and also their sa...

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Published in:	European journal of hospital pharmacy. Science and practice Vol. 28; no. Suppl 1; p. A91
Main Authors:	Morego Soler, A, Maestre Fullana, MA, Cano Collado, V, Galan Ramos, N, Trujullano Ruiz, A, Perello Rossello, F, Crespi Magro, MM, Barrientos Ruiz, G, Amer Alomar, F, Morey Riera, MA, Llodra Ortola, V
Format:	Journal Article
Language:	English
Published:	London BMJ Publishing Group LTD 01-03-2021
Subjects:	Conflicts of interest Erythema Monoclonal antibodies
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Summary:	Background and importanceCalcitonin gene related peptide (CGRP) receptor inhibitors are a new group of drugs that have been included for migraine pharmacotherapy and migraine prevention. Erenumab and galcanezumab have notable individual variance and we wanted to explore this effect and also their safety.Aim and objectivesTo assess the efficacy and safety of the CGRP receptor inhibitors erenumab and galcanezumab.Material and methodsIn this 6 month observational retrospective study (January to June 2020), based on patient interviews, we obtained demographic parameters, reduced monthly migraine days (RDMM), a response rate of 50% (TR50) and adverse effects during treatment. RDMM are calculated by subtracting the migraine days 4 weeks before starting the treatment from the monthly migraine days between weeks 9 and 12 of treatment. TR50 are patients who achieved at least a 50% reduction in monthly migraine days in comparison with their initial condition.Results31 patients were registered with a mean age of 43.9 years (±12.1), 77.4% were women and 22.6% were men. 66.7% (n=22) of patients were treated with erenumab and 33.3% (n=9) with galcanezumab. The RDMM for erenumab was −10.5 days (−17.1; −3.9) and a TR50 of 81.8% (n=18). For galcanezumab, the RDMM was −5.5 days (−8.6; −0.8) and a TR50 of 33.3% (n=3). The most frequent adverse reactions to erenumab were constipation (31.8% (7)) and erythema at the injection site (9.1% (2)); for galcanezumab, it was erythema at the injection site (22.2% (2)).Conclusion and relevanceDespite the disparity between the sample sizes of both drugs, in our study erenumab showed greater reduction in migraine days in comparison with patients treated with galcanezumab. Both drugs were safe in all patients, showing mild adverse reactions that did not require intervention.References and/or acknowledgementsConflict of interestNo conflict of interest
ISSN:	2047-9956 2047-9964
DOI:	10.1136/ejhpharm-2021-eahpconf.186