Search Results - "Crescenzo, Ramona"

THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors by Cayrol, Florencia, Praditsuktavorn, Pannee, Fernando, Tharu M., Kwiatkowski, Nicholas, Marullo, Rosella, Calvo-Vidal, M. Nieves, Phillip, Jude, Pera, Benet, Yang, Shao Ning, Takpradit, Kaipol, Roman, Lidia, Gaudiano, Marcello, Crescenzo, Ramona, Ruan, Jia, Inghirami, Giorgio, Zhang, Tinghu, Cremaschi, Graciela, Gray, Nathanael S., Cerchietti, Leandro

“…Peripheral T-cell lymphomas (PTCL) are aggressive diseases with poor response to chemotherapy and dismal survival. Identification of effective strategies to…”
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The methyltransferase domain of DNMT1 is an essential domain in acute myeloid leukemia independent of DNMT3A mutation by Bhogal, Balpreet, Weir, Barbara A., Crescenzo, Ramona, Marien, Ann, Kwon, Min Chul, Philippar, Ulrike, Cowley, Glenn S.

“…Aberrant DNA methylation patterns are a prominent feature of cancer. Methylation of DNA is mediated by the DNA methyltransferase (DNMT) protein family, which…”
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Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes by Boi, Michela, Todaro, Maria, Vurchio, Valentina, Yang, Shao Ning, Moon, John, Kwee, Ivo, Rinaldi, Andrea, Pan, Heng, Crescenzo, Ramona, Cheng, Mangeng, Cerchietti, Leandro, Elemento, Olivier, Riveiro, Maria E, Cvitkovic, Esteban, Bertoni, Francesco, Inghirami, Giorgio

“…Anaplastic large cell lymphomas (ALCL) represent a peripheral T-cell lymphoma subgroup, stratified based on the presence or absence of anaplastic lymphoma…”
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Correction: Corrigendum: THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors by Cayrol, Florencia, Praditsuktavorn, Pannee, Fernando, Tharu M., Kwiatkowski, Nicholas, Marullo, Rossella, Calvo-Vidal, M. Nieves, Phillip, Jude, Pera, Benet, Yang, Shao Ning, Takpradit, Kaipol, Roman, Lidia, Gaudiano, Marcello, Crescenzo, Ramona, Ruan, Jia, Inghirami, Giorgio, Zhang, Tinghu, Cremaschi, Graciela, Gray, Nathanael S, Cerchietti, Leandro

“…Nature Communications 8: Article number: 14290 (2017); Published: 30 January 2017; Updated: 20 February 2017 The original version of this Article contained an…”
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Anaplastic lymphoma kinase inhibitors by Crescenzo, Ramona, Inghirami, Giorgio

“…Graphical abstract ALK signaling: Wild type (WT) ALK receptor (ALKr) requires ligand dimerization to trigger cellular signaling, conversely mutated ALKr and…”
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Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma by Crescenzo, Ramona, Abate, Francesco, Lasorsa, Elena, Tabbo’, Fabrizio, Gaudiano, Marcello, Chiesa, Nicoletta, Di Giacomo, Filomena, Spaccarotella, Elisa, Barbarossa, Luigi, Ercole, Elisabetta, Todaro, Maria, Boi, Michela, Acquaviva, Andrea, Ficarra, Elisa, Novero, Domenico, Rinaldi, Andrea, Tousseyn, Thomas, Rosenwald, Andreas, Kenner, Lukas, Cerroni, Lorenzo, Tzankov, Alexander, Ponzoni, Maurilio, Paulli, Marco, Weisenburger, Dennis, Chan, Wing C., Iqbal, Javeed, Piris, Miguel A., Zamo’, Alberto, Ciardullo, Carmela, Rossi, Davide, Gaidano, Gianluca, Pileri, Stefano, Tiacci, Enrico, Falini, Brunangelo, Shultz, Leonard D., Mevellec, Laurence, Vialard, Jorge E., Piva, Roberto, Bertoni, Francesco, Rabadan, Raul, Inghirami, Giorgio

“…A systematic characterization of the genetic alterations driving ALCLs has not been performed. By integrating massive sequencing strategies, we provide a…”
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SETDB1 Suppresses Interferon Responses and NK Cell-Mediated Immunosurveillance Specifically in Monocytic AML by Chang, Yu-Hsuan, Yamamoto, Keita, Fujino, Takeshi, Wang, Teh-Wei, Sugimoto, Emi, Zhang, Wenyu, Yabushita, Tomohiro, Pietsch, E. Christine, Weir, Barbara A., Crescenzo, Ramona, Cowley, Glenn S., Attar, Ricardo M., Philippar, Ulrike, Enomoto, Yutaka, Imai, Yoichi, Kitamura, Toshio, Goyama, Susumu

“…Acute myeloid leukemia (AML) with monocytic differentiation (monocytic AML) responds poorly to current treatments, including venetoclax-based therapy. To…”
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Abstract 2885: Somatic mutation of STAT3 leads to the preferential Th17 differentiation in human naïve CD4-positive cells and favor TCR-mediated proliferation by Crescenzo, Ramona, Fragliasso, Valentina, Gaudiano, Marcello, Pizzi, Marco, Inghirami, Giorgio

“…Abstract Intro: Mature Th17 lymphocytes play a key role in the host defenses against bacteria and fungi although unchecked Th17 activation can lead to…”
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Abstract 2885: Somatic mutation of STAT3 leads to the preferential Th17 differentiation in human nave CD4-positive cells and favor TCR-mediated proliferation by Crescenzo, Ramona, Fragliasso, Valentina, Gaudiano, Marcello, Pizzi, Marco, Inghirami, Giorgio

“…Intro: Mature Th17 lymphocytes play a key role in the host defenses against bacteria and fungi although unchecked Th17 activation can lead to autoimmune…”
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SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation by Chang, Yu-Hsuan, Yamamoto, Keita, Fujino, Takeshi, Wang, Teh-Wei, Sugimoto, Emi, Zhang, Wenyu, Yabushita, Tomohiro, Suzaki, Ken, Pietsch, E. Christine, Weir, Barbara A., Crescenzo, Ramona, Cowley, Glenn S., Attar, Ricardo, Philippar, Ulrike, Wunderlich, Mark, Mizukawa, Benjamin, Zheng, Yi, Enomoto, Yutaka, Imai, Yoichi, Kitamura, Toshio, Goyama, Susumu

“…Monocytic acute myeloid leukemia (AML) responds poorly to current treatments, including venetoclax-based therapy. We conducted in vivo and in vitro CRISPR-Cas9…”
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Abstract 1383: A CRISPR-Cas9 tiling screen to identify functional domains within DNMT1 and/or DNMT3B that can be targeted for therapeutic intervention in AML by Bhogal, Balpreet, Weir, Barbara, Crescenzo, Ramona, Kwon, Min Chul, Philippar, Ulrike, Attar, Ricardo, Cowley, Glenn, Pocalyko, David

“…Abstract DNA methylation is an epigenetic mechanism that regulates gene expression during many stages of development, including genomic imprinting, stem cell…”
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Corrigendum: THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors by Cayrol, Florencia, Praditsuktavorn, Pannee, Fernando, Tharu M, Kwiatkowski, Nicholas, Marullo, Rossella, Calvo-Vidal, M Nieves, Phillip, Jude, Pera, Benet, Yang, Shao Ning, Takpradit, Kaipol, Roman, Lidia, Gaudiano, Marcello, Crescenzo, Ramona, Ruan, Jia, Inghirami, Giorgio, Zhang, Tinghu, Cremaschi, Graciela, Gray, Nathanael S, Cerchietti, Leandro

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The Pro-Tumorigenic Vascular Niche Sustains the T-Cell Acute Lymphoblastic Leukemia Phenotype and Fosters Resistance to Therapy by Di Giacomo, Filomena, Wang, Xujun, Fiore, Danilo, Consolino, Lorena, Phillip, Jude, Gaudiano, Marcello, Roman-Gonzalez, Lydia, Crescenzo, Ramona, Chiaretti, Sabina, Gianfelici, Valentina, Michael, Ginsberg, Duran, Jose Gabriel Barcia, Salinero, Jesus Maria Gomez, Bareja, Rohan, Elemento, Olivier, Guarini, Anna, Foà, Robin, Cerchietti, Leandro, Rafii, Shahin, Inghirami, Giorgio

“…Introduction. T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous malignancy associated with a high risk of treatment failure. Efforts…”
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Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma by Crescenzo, Ramona, Abate, Francesco, Lasorsa, Elena, Tabbo’, Fabrizio, Gaudiano, Marcello, Chiesa, Nicoletta, Di Giacomo, Filomena, Spaccarotella, Elisa, Barbarossa, Luigi, Ercole, Elisabetta, Todaro, Maria, Boi, Michela, Acquaviva, Andrea, Ficarra, Elisa, Novero, Domenico, Rinaldi, Andrea, Tousseyn, Thomas, Rosenwald, Andreas, Kenner, Lukas, Cerroni, Lorenzo, Tzankov, Alexander, Ponzoni, Maurilio, Paulli, Marco, Weisenburger, Dennis, Chan, Wing C., Iqbal, Javeed, Piris, Miguel A., Zamo’, Alberto, Ciardullo, Carmela, Rossi, Davide, Gaidano, Gianluca, Pileri, Stefano, Tiacci, Enrico, Falini, Brunangelo, Shultz, Leonard D., Mevellec, Laurence, Vialard, Jorge E., Piva, Roberto, Bertoni, Francesco, Rabadan, Raul, Inghirami, Giorgio

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Convergent Mutations and New Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma by Crescenzo, Ramona, Abate, Francesco, Lasorsa, Elena, Tabbo’, Fabrizio, Gaudiano, Marcello, Chiesa, Nicoletta, Di Giacomo, Filomena, Spaccarotella, Elisa, Barbarossa, Luigi, Todaro, Maria, Boi, Michela, Tousseyn, Thomas, Rosenwald, Andreas, Kenner, Lukas, Rossi, Davide, Mevellec, Laurence, Vialard, Jorge, Bertoni, Francesco, Rabadan, Raul, Inghirami, Giorgio

“…Introduction. If the role of ALK chimeras is well known in the pathogenesis of ALK+ Anaplastic Large Cell Lymphoma (ALCL), the mechanisms leading to the…”
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ALK Signaling and Target Therapy in Anaplastic Large Cell Lymphoma by Tabbó, Fabrizio, Barreca, Antonella, Piva, Roberto, Inghirami, Giorgio

“…The discovery by Morris et al. (1994) of the genes contributing to the t(2;5)(p23;q35) translocation has laid the foundation for a molecular based recognition…”
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