Search Results - "Crennell, Susan J"

Staphylococcal Complement Evasion Protein Sbi Stabilises C3d Dimers by Inducing an N-Terminal Helix Swap by Dunphy, Rhys W, Wahid, Ayla A, Back, Catherine R, Martin, Rebecca L, Watts, Andrew G, Dodson, Charlotte A, Crennell, Susan J, van den Elsen, Jean M H

“…is an opportunistic pathogen that is able to thwart an effective host immune response by producing a range of immune evasion molecules, including binder of IgG…”
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Insights Into the Structure-Function Relationships of Dimeric C3d Fragments by Wahid, Ayla A, Dunphy, Rhys W, Macpherson, Alex, Gibson, Beth G, Kulik, Liudmila, Whale, Kevin, Back, Catherine, Hallam, Thomas M, Alkhawaja, Bayan, Martin, Rebecca L, Meschede, Ingrid, Laabei, Maisem, Lawson, Alastair D G, Holers, V Michael, Watts, Andrew G, Crennell, Susan J, Harris, Claire L, Marchbank, Kevin J, van den Elsen, Jean M H

“…Cleavage of C3 to C3a and C3b plays a central role in the generation of complement-mediated defences. Although the thioester-mediated surface deposition of C3b…”
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Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex by Marrott, Nia L, Marshall, Jacqueline J T, Svergun, Dmitri I, Crennell, Susan J, Hough, David W, van den Elsen, Jean M H, Danson, Michael J

“…The four-component polypeptides of the 2-oxoacid dehydrogenase complex from the thermophilic archaeon Thermoplasma acidophilum assemble to give an active…”
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Structurally Informed Site-Directed Mutagenesis of a Stereochemically Promiscuous Aldolase To Afford Stereochemically Complementary Biocatalysts by Royer, Sylvain F., Haslett, Luke, Crennell, Susan J., Hough, David W., Danson, Michael J., Bull, Steven D.

“…2-Keto-3-deoxygluconate aldolase from the hyperthermophile Sulfolobus solfataricus is a highly thermostable type I aldolase that can catalyze carbon−carbon…”
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Post-translational modification in the archaea: structural characterization of multi-enzyme complex lipoylation by Posner, Mareike G, Upadhyay, Abhishek, Crennell, Susan J, Watson, Andrew J A, Dorus, Steve, Danson, Michael J, Bagby, Stefan

“…Lipoylation, the covalent attachment of lipoic acid to 2-oxoacid dehydrogenase multi-enzyme complexes, is essential for metabolism in aerobic bacteria and…”
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Role of the Hemagglutinin-Neuraminidase Protein in the Mechanism of Paramyxovirus-Cell Membrane Fusion by Takimoto, Toru, Taylor, Garry L, Connaris, Helen C, Crennell, Susan J, Portner, Allen

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Structures of mesophilic and extremophilic citrate synthases reveal rigidity and flexibility for function by Wells, Stephen A., Crennell, Susan J., Danson, Michael J.

“…ABSTRACT Citrate synthase (CS) catalyses the entry of carbon into the citric acid cycle and is highly‐conserved structurally across the tree of life. Crystal…”
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Structure of an acetylating aldehyde dehydrogenase from the thermophilic ethanologen Geobacillus thermoglucosidasius by Extance, Jonathan, Danson, Michael J., Crennell, Susan J.

“…Acetylating aldehyde dehydrogenases (AcAldDH) catalyse the acetylation of Coenzyme‐A (CoA), or in reverse generate acetaldehyde from Acetyl‐CoA using NADH as a…”
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Structurally Informed Mutagenesis of a Stereochemically Promiscuous Aldolase Produces Mutants That Catalyze the Diastereoselective Syntheses of All Four Stereoisomers of 3‑Deoxy-hexulosonic Acid by Royer, Sylvain F., Gao, Xuan, Groleau, Robin R., van der Kamp, Marc W., Bull, Steven D., Danson, Michael J., Crennell, Susan J.

“…A 2-keto-3-deoxygluconate aldolase from the hyperthermophile Sulfolobus solfataricus catalyzes the nonstereoselective aldol reaction of pyruvate and…”
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Dimerisation and an Increase in Active Site Aromatic Groups as Adaptations to High Temperatures: X-ray Solution Scattering and Substrate-bound Crystal Structures of Rhodothermus marinus Endoglucanase Cel12A by Crennell, Susan J., Cook, Danielle, Minns, Abby, Svergun, Dmitri, Andersen, Rasmus L., Nordberg Karlsson, Eva

“…Cellulose, a polysaccharide consisting of β-1,4-linked glucose, is the major component of plant cell walls and consequently one of the most abundant…”
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Distinctive phosphoinositide- and Ca2+-binding properties of normal and cognitive performance–linked variant forms of KIBRA C2 domain by Posner, Mareike G., Upadhyay, Abhishek, Ishima, Rieko, Kalli, Antreas C., Harris, Gemma, Kremerskothen, Joachim, Sansom, Mark S.P., Crennell, Susan J., Bagby, Stefan

“…Kidney- and brain-expressed protein (KIBRA), a multifunctional scaffold protein with around 20 known binding partners, is involved in memory and cognition,…”
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Insights into the Substrate Specificity of Archaeal Entner–Doudoroff Aldolases: The Structures of Picrophilus torridus 2‑Keto-3-deoxygluconate Aldolase and Sulfolobus solfataricus 2‑Keto-3-deoxy-6-phosphogluconate Aldolase in Complex with 2‑Keto-3-deoxy-6-phosphogluconate by Zaitsev, Viatcheslav, Johnsen, Ulrike, Reher, Matthias, Ortjohann, Marius, Taylor, Garry L, Danson, Michael J, Schönheit, Peter, Crennell, Susan J

“…The thermoacidophilic archaea Picrophilus torridus and Sulfolobus solfataricus catabolize glucose via a nonphosphorylative Entner–Doudoroff pathway and a…”
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Structure of a bifunctional alcohol dehydrogenase involved in bioethanol generation in Geobacillus thermoglucosidasius by Extance, Jonathan, Crennell, Susan J., Eley, Kirstin, Cripps, Roger, Hough, David W., Danson, Michael J.

“…Bifunctional alcohol/aldehyde dehydrogenase (ADHE) enzymes are found within many fermentative microorganisms. They catalyse the conversion of an acyl‐coenzyme…”
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The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase by Chen, Zexin, Marcé, Patricia, Resende, Ricardo, Alzari, Pedro M., Frasch, A. Carlos, van den Elsen, Jean M.H., Crennell, Susan J., Watts, Andrew G.

“…The trans-sialidase protein expressed by Trypanosoma cruzi is an important enzyme in the life cycle of this human pathogenic parasite and is considered a…”
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Structural insights of RmXyn10A – A prebiotic-producing GH10 xylanase with a non-conserved aglycone binding region by Aronsson, Anna, Güler, Fatma, Petoukhov, Maxim V., Crennell, Susan J., Svergun, Dmitri I., Linares-Pastén, Javier A., Nordberg Karlsson, Eva

“…Hydrolysis of arabinoxylan (AX) by glycoside hydrolase family 10 (GH10) xylanases produces xylo- and arabinoxylo-oligosaccharides ((A)XOS) which have shown…”
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A novel β-xylosidase structure from Geobacillus thermoglucosidasius: the first crystal structure of a glycoside hydrolase family GH52 enzyme reveals unpredicted similarity to other glycoside hydrolase folds by Espina, Giannina, Eley, Kirstin, Pompidor, Guillaume, Schneider, Thomas R., Crennell, Susan J., Danson, Michael J.

“…Geobacillus thermoglucosidasius is a thermophilic bacterium that is able to ferment both C6 and C5 sugars to produce ethanol. During growth on hemicellulose…”
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Germline Humanization of a Non-human Primate Antibody that Neutralizes the Anthrax Toxin, by in Vitro and in Silico Engineering by Pelat, Thibaut, Bedouelle, Hugues, Rees, Anthony R., Crennell, Susan J., Lefranc, Marie-Paule, Thullier, Philippe

“…Fab 35PA83 is an antibody fragment of non-human primate origin that neutralizes the anthrax lethal toxin. Human antibodies are usually preferred when clinical…”
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Crystal structure of an inferred ancestral bacterial pyruvate decarboxylase by Buddrus, Lisa, Andrews, Emma S. V., Leak, David J., Danson, Michael J., Arcus, Vickery L., Crennell, Susan J.

“…Pyruvate decarboxylase (PDC; EC 4.1.1.1) is a key enzyme in homofermentative metabolism where ethanol is the major product. PDCs are thiamine pyrophosphate‐…”
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The catalytic core of an archaeal 2‐oxoacid dehydrogenase multienzyme complex is a 42‐mer protein assembly by Marrott, Nia L., Marshall, Jacqueline J. T., Svergun, Dmitri I., Crennell, Susan J., Hough, David W., Danson, Michael J., van den Elsen, Jean M. H.

“…The dihydrolipoyl acyl‐transferase (E2) enzyme forms the structural and catalytic core of the tripartite 2‐oxoacid dehydrogenase multienzyme complexes of the…”
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Crystal structure of pyruvate decarboxylase from Zymobacter palmae by Buddrus, Lisa, Andrews, Emma S. V., Leak, David J., Danson, Michael J., Arcus, Vickery L., Crennell, Susan J.

“…Pyruvate decarboxylase (PDC; EC 4.1.1.1) is a thiamine pyrophosphate‐ and Mg2+ ion‐dependent enzyme that catalyses the non‐oxidative decarboxylation of…”
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