$Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae)$
QR Code

Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae)

Magnolia ovata (A.St.-Hil.) Spreng (formerly Talauma ovata), known as “pinha-do-brejo” or “baguaçu”, is a large tree widely distributed in Brazil. Its trunk bark has been used in folk medicine against fever. However, no data have been published to support the antipyretic ethnopharmacological use. Th...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of ethnopharmacology Vol. 124; no. 3; pp. 369 - 376
Main Authors:	Kassuya, Cândida Aparecida Leite, Cremoneze, Aline, Barros, Letícia Ferrari Lemos, Simas, Alex Sandro, da Rocha Lapa, Fernanda, Mello-Silva, Renato, Stefanello, Maria Élida Alves, Zampronio, Aleksander Roberto
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 30-07-2009 Amsterdam; New York: Elsevier Elsevier
Subjects:	Acetylglucosaminidase - metabolism Analgesics, Non-Narcotic - pharmacology animal models Animals Anti-inflammatory anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antipyretic antipyretics bark Biological and medical sciences Carrageenan Cell Movement - drug effects costunolide dosage Edema - chemically induced Edema - prevention & control Ethanol Exudates and Transudates - metabolism Fever Fever - chemically induced Fever - prevention & control fractionation General pharmacology Indicators and Reagents inhibitory concentration 50 Leukocytes - drug effects Lipopolysaccharides Magnolia Magnolia - chemistry Magnolia ovata Magnoliaceae Male Medical sciences medicinal plants medicinal properties Methylene Chloride Mice oral administration Peroxidase - metabolism Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Pleural Cavity - cytology pleurisy model Sesquiterpenes - chemistry Sesquiterpenes - pharmacology Solvents Brazil Antipyretic Magnolia ovata Mice Anti-inflammatory Magnoliaceae Fever Germacranolid Extract Medicinal plant Dicotyledones Sesquiterpenes Angiospermae Terpenoid Pharmacognosy Rodentia Antiinflammatory agent Lactone Woody plant Magnolia Vertebrata Mammalia Mouse Animal Plant origin Spermatophyta
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Magnolia ovata (A.St.-Hil.) Spreng (formerly Talauma ovata), known as “pinha-do-brejo” or “baguaçu”, is a large tree widely distributed in Brazil. Its trunk bark has been used in folk medicine against fever. However, no data have been published to support the antipyretic ethnopharmacological use. This study investigated the antipyretic and anti-inflammatory effects of the ethanolic extract (EEMO), dichloromethane fraction (DCM), and the isolated compound costunolide. The antipyretic and anti-inflammatory activities were evaluated in experimental models of fever and inflammation in mice. The oral administration of EEMO, DCM and costunolide inhibited carrageenan (Cg)-induced paw oedema (ID 50 72.35 (38.64–135.46) mg/kg, 5.8 (2.41–14.04) mg/kg and 0.18 (0.12–0.27) mg/kg, respectively) and was effective in abolishing lipopolysaccharide (LPS)-induced fever (30 mg/kg, 4.5 mg/kg and 0.15 mg/kg, respectively). EEMO was also effective in reducing cell migration in the pleurisy model. Intraplantar injection of costunolide also reduced the paw oedema, myeloperoxidase and N-acetyl-glucosaminidase activity induced by Cg in mice. Collectively, these results show, for the first time, that extracts obtained from Magnolia ovata possess antipyretic and anti-inflammatory properties, and costunolide appears to be the compound responsible for these effects.
Bibliography:	http://dx.doi.org/10.1016/j.jep.2009.06.003 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0378-8741 1872-7573
DOI:	10.1016/j.jep.2009.06.003