β-Cyclodextrins alter the energy metabolism-related enzyme activities in rats

β-Cyclodextrins alter the energy metabolism-related enzyme activities in rats

Although widely used in medicine, separation technology, and other fields, the effects of cyclodextrins on the activities of phosphoryl transfer enzymes have not been previously evaluated. In vivo studies evaluated the function of cyclodextrins as active compounds. Despite the use of cyclodextrins a...

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Published in:Anais da Academia Brasileira de Ciências Vol. 95; no. 2; p. e20201783
Main Authors: Ianiski, Francine R, Oliveira, Amanda L DE, Mezzomo, Nathana Jamille, Franceschi, Itiane D DE, Carmo, Guilherme M DO, Cremonese, Camila R, Baldissera, Matheus D, Zanon, Jenifer P, Kolling, Jenifer, Friederich, Jordana Daniela, Silva, Ivana Z, Giongo, Janice L, Feksa, Luciane R, Vaucher, Rodrigo A, Wannmacher, Clovis Milton D, Rech, Virginia C
Format: Journal Article
Language:English
Published: Brazil Academia Brasileira de Ciências 01-01-2023
Subjects:
2-Hydroxypropyl-beta-cyclodextrin - pharmacology
adenylate kinase
Animals
beta-Cyclodextrins - pharmacology
biochemical
blood serum
creatine kinase
Cyclodextrins - pharmacology
Energy Metabolism
MULTIDISCIPLINARY SCIENCES
oxidative stress
pyruvate kinase
Rats
adenylate kinase
creatine kinase
biochemical
oxidative stress
pyruvate kinase
blood serum
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Summary:Although widely used in medicine, separation technology, and other fields, the effects of cyclodextrins on the activities of phosphoryl transfer enzymes have not been previously evaluated. In vivo studies evaluated the function of cyclodextrins as active compounds. Despite the use of cyclodextrins as active compounds, the effects of cyclodextrins on hepatic and renal tissues remain to be fully elucidated. The primary objective of this study was to evaluate the effects of β- cyclodextrins, methyl-β-cyclodextrin (M-β- cyclodextrins), and (2-hydroxypropyl)-β-cyclodextrin (HP-β-cyclodextrins) on enzyme activities regulating the maintenance of energy homeostasis in the kidney and liver tissues in relation to toxicity. Serum levels of liver and kidney markers were measured, and oxidative stress parameters were assessed. After 60-day treatments, we observed that the administration of β-cyclodextrins and M-β-cyclodextrins inhibited the hepatic activity of pyruvate kinase, an irreversible enzyme within the glycolytic pathway. Additionally, administration of HP-β-cyclodextrins inhibited creatine kinase activity and increased the total sulfhydryl content in kidneys. Here, we demonstrated for the first time that β-cyclodextrins, M-β-cyclodextrins, and HP-β-cyclodextrins cause bioenergetic dysfunction in renal and hepatic tissues. These findings suggest that understanding the balance between cyclodextrins' efficacy and adverse effects is essential for better accepting their use in medicine.
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ISSN:0001-3765
1678-2690
1678-2690
DOI:10.1590/0001-3765202320201783