Search Results - "Cremers, Eline M.P."

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia by Zambetti, Noemi A., Ping, Zhen, Chen, Si, Kenswil, Keane J.G., Mylona, Maria A., Sanders, Mathijs A., Hoogenboezem, Remco M., Bindels, Eric M.J., Adisty, Maria N., Van Strien, Paulina M.H., van der Leije, Cindy S., Westers, Theresia M., Cremers, Eline M.P., Milanese, Chiara, Mastroberardino, Pier G., van Leeuwen, Johannes P.T.M., van der Eerden, Bram C.J., Touw, Ivo P., Kuijpers, Taco W., Kanaar, Roland, van de Loosdrecht, Arjan A., Vogl, Thomas, Raaijmakers, Marc H.G.P.

“…Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system, but the underlying molecular mechanisms and…”
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Expression levels of genes implicated in the working mechanism of lenalidomide predict treatment response in lower risk myelodysplastic syndrome patients by In 't Hout, Florentien E M, Scheele, Thessa N, Westers, Theresia M, Alhan, Canan, Duetz, Carolien, Cremers, Eline M P, Visser-Wisselaar, Heleen A, Verbrugge, Annelies, Chitu, Dana A, Van der Reijden, Bert A, De Graaf, Aniek O, Van de Loosdrecht, Arjan A, Jansen, Joop H

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Multiparameter flow cytometry is instrumental to distinguish myelodysplastic syndromes from non-neoplastic cytopenias by Cremers, Eline M.P, Westers, Theresia M, Alhan, Canan, Cali, Claudia, Wondergem, Mariëlle J, Poddighe, Pino J, Ossenkoppele, Gert J, van de Loosdrecht, Arjan A

“…Abstract Mandatory for the diagnosis of myelodysplastic syndromes (MDS) is the presence of dysplasia in >10% of cells within one or more cell lineages or…”
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Implementation of erythroid lineage analysis by flow cytometry in diagnostic models for myelodysplastic syndromes by Cremers, Eline M P, Westers, Theresia M, Alhan, Canan, Cali, Claudia, Visser-Wisselaar, Heleen A, Chitu, Dana A, van der Velden, Vincent H J, Te Marvelde, Jeroen G, Klein, Saskia K, Muus, Petra, Vellenga, Edo, de Greef, Georgina E, Legdeur, Marie-Cecile C J C, Wijermans, Pierre W, Stevens-Kroef, Marian J P L, Silva-Coelho, Pedro da, Jansen, Joop H, Ossenkoppele, Gert J, van de Loosdrecht, Arjan A

“…Flow cytometric analysis is a recommended tool in the diagnosis of myelodysplastic syndromes. Current flow cytometric approaches evaluate the (im)mature…”
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A prospective non-interventional study on the impact of transfusion burden and related iron toxicity on outcome in myelodysplastic syndromes undergoing allogeneic hematopoietic cell transplantation by Cremers, Eline M.P., de Witte, Theo, de Wreede, Liesbeth, Eikema, Diderik-Jan, Koster, Linda, van Biezen, Anja, Finke, Jürgen, Socié, Gerard, Beelen, Dietrich, Maertens, Johan, Nagler, Arnon, Kobbe, Guido, Ziagkos, Dimitris, Itälä-Remes, Maija, Gedde-Dahl, Tobias, Sierra, Jorge, Niederwieser, Dietger, Ljungman, Per, Beguin, Yves, Ozkurt, Zubeyde Nur, Anagnostopoulos, Achilles, Jindra, Pavel, Robin, Marie, Kröger, Nicolaus

“…Most myelodysplastic syndromes (MDS)-patients receive multiple red blood cell transfusions (RBCT). Transfusions may cause iron-related toxicity and mortality,…”
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Optimized gating strategy and supporting flow cytometry data for the determination of the Ki-67 proliferation index in the diagnosis of myelodysplastic syndrome by Mestrum, Stefan G.C., Cremers, Eline M.P., de Wit, Norbert C.J., Drent, Roosmarie J.M., Ramaekers, Frans C.S., Hopman, Anton H.N., Leers, Math P.G.

“…This Data in Brief article presents a novel flow cytometric assay used to acquire and process the data presented and discussed in the research paper by Mestrum…”
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Immunophenotyping for diagnosis and prognosis in MDS: Ready for general application? by Cremers, Eline M.P., MD, Alhan, Canan, MD, Westers, Theresia M., PhD, Ossenkoppele, Gert J., MD, PhD, van de Loosdrecht, Arjan A., MD, PhD

“…Myelodysplastic syndromes is a heterogeneous group of bone marrow diseases ranging from low risk to high risk subtypes that may rapidly evolve to acute myeloid…”
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Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes by Ping, Zhen, Chen, Si, Hermans, Sjoerd J. F., Kenswil, Keane J. G., Feyen, Jacqueline, van Dijk, Claire, Bindels, Eric M. J., Mylona, Athina M., Adisty, Niken M., Hoogenboezem, Remco M., Sanders, Mathijs A., Cremers, Eline M. P., Lindenbergh-Kortleve, Dicky J., Samsom, Janneke N., van de Loosdrecht, Arjan A., Raaijmakers, Marc H. G. P.

“…Highlights Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS. Activation of NF-κB in mesenchymal cells leads to transcriptional…”
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Distinct bone marrow immunophenotypic features define the splicing factor 3B subunit 1 (SF3B1)‐mutant myelodysplastic syndromes subtype by Duetz, Carolien, Westers, Theresia M., in ’t Hout, Florentien E. M., Cremers, Eline M. P., Alhan, Canan, Venniker‐Punt, Bianca, Visser‐Wisselaar, Heleen A., Chitu, Dana A., Graaf, Aniek O., Smit, Linda, Jansen, Joop H., Loosdrecht, Arjan A.

“…Summary Splicing factor 3B subunit 1 (SF3B1) mutations define a distinct myelodysplastic syndromes (MDS) patient group with a relatively favourable disease…”
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Integration of the Ki-67 proliferation index into the Ogata score improves its diagnostic sensitivity for low-grade myelodysplastic syndromes by Mestrum, Stefan G.C., Cremers, Eline M.P., de Wit, Norbert C.J., Drent, Roosmarie J.M., Ramaekers, Frans C.S., Hopman, Anton H.N., Leers, Math P.G.

“…[Display omitted] •The Ki-67 proliferation index can be of help to diagnose (low-grade) MDS.•Integrating Ki-67 into the Ogata score increased its sensitivity…”
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Fatigue in children: reliability and validity of the Dutch PedsQL™ Multidimensional Fatigue Scale by Gordijn, M. Suzanne, Cremers, Eline M. P., Kaspers, Gertjan J. L., Gemke, Reinoud J. B. J.

“…Purpose The aim of the study is to report on the feasibility, reliability, validity, and the norm-references of the Dutch version of the PedsQL ™…”
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High flow cytometric scores identify adverse prognostic subgroups within the revised international prognostic scoring system for myelodysplastic syndromes by Alhan, Canan, Westers, Theresia M., Cremers, Eline M. P., Cali, Claudia, Witte, Birgit I., Ossenkoppele, Gert J., Loosdrecht, Arjan A.

“…Summary The estimation of survival of myelodysplastic syndromes (MDS) and risk of progression into acute myeloid leukaemia is challenging due to the…”
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Genomic array as compared to karyotyping in myelodysplastic syndromes in a prospective clinical trial by Stevens‐Kroef, Marian J., Olde Weghuis, Daniel, ElIdrissi‐Zaynoun, Najat, van der Reijden, Bert, Cremers, Eline M. P., Alhan, Canan, Westers, Theresia M., Visser‐Wisselaar, Heleen A., Chitu, Dana A., Cunha, Sonia M., Vellenga, Edo, Klein, Saskia K., Wijermans, Pierre, de Greef, Georgine E., Schaafsma, M. Ron, Muus, Petra, Ossenkoppele, Gert J., van de Loosdrecht, Arjan A., Jansen, Joop H.

“…Karyotyping is considered as the gold standard in the genetic subclassification of myelodysplastic syndrome (MDS). Oligo/SNP‐based genomic array profiling is a…”
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Application of flow cytometry for myelodysplastic syndromes: Pitfalls and technical considerations by Alhan, Canan, Westers, Theresia M., Cremers, Eline M. P., Cali, Claudia, Ossenkoppele, Gert J., van de Loosdrecht, Arjan A.

“…The application of flow cytometry (FC) is recommended as part of the diagnostic approach for MDS. The complexity of flow cytometric analysis of bone marrow…”
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A Five Parameter Based Flow Cytometric Scoring System Refines the Revised International Prognostic Scoring System for Myelodysplastic Syndromes by Alhan, Canan, Westers, Theresia M., Cremers, Eline M.P., Cali, Claudia, Ossenkoppele, Gert J, van de Loosdrecht, Arjan A.

“…Abstract 3849 The International Prognostic Scoring System (IPSS) has found widespread application in the clinical practice of myelodysplastic syndromes (MDS)…”
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Flow Cytometry Is Highly Predictive In Excluding Myelodysplastic Syndromes In Patients With Indeterminable Cytopenia: A Prospective Analysis Of 316 Patients by Cremers, Eline M.P., Westers, Theresia M, Alhan, Canan, Wondergem, Marielle J., Poddighe, Pino J., Cali, Claudia, Schouten, C.W.M., Ossenkoppele, Gert J., Van de Loosdrecht, Arjan A.

“…Myelodysplastic syndromes (MDS) constitute a heterogeneous group of hematopoietic stem cell disorders, characterized by ineffective hematopoiesis resulting in…”
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The Proliferation Index of Erythroid Cells Predicts the Development of Transfusion‐dependence in Myelodysplastic Syndrome Patients With Mildly Reduced Hemoglobin Levels at Initial Diagnosis by Mestrum, Stefan G. C., Wit, Norbert C. J., Cremers, Eline M. P., Drent, Roosmarie J. M., Ramaekers, Frans C. S., Hopman, Anton H. N., Leers, Math P. G.

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Identification Of Chromosomal Abnormalities By Microarray-Based Genomic Profiling As Compared To Karyotyping In Patients With Low and Intermediate-1 Risk Myelodysplastic Syndromes Within a Prospective Clinical Trial: A Study On Behalf Of The HOVON89 Study Group by Stevens-Kroef, Marian J.P.L., Simons, Annet, El Idrissi-Zaynoun, Najat, van der Reijden, Bert A., Cremers, Eline M.P., Alhan, Canan, Westers, Theresia M., Visser-Wisselaar, Heleen A., Chitu, Dana, Vellenga, Edo, Klein, S.K., Wijermans, Pierre W., De Greef, Georgine E., Schaafsma, Martyn R., van Marwijk Kooy, M., Muus, Petra, Ossenkoppele, Gert J., van de Loosdrecht, Arjan A., Jansen, Joop H.

“…Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematopoietic disorders, characterized by ineffective hematopoiesis resulting in…”
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Validation Of a Multi-Diagnostic Approach Including Flow Cytometry To Identify Specific Risk Categories Within Low and Intermediate-1 Risk Myelodysplastic Syndromes Within a Prospective Clinical Trial: A Study On Behalf Of The HOVON89 Study Group by Cremers, Eline M.P., Westers, Theresia M., Alhan, Canan, Cali, Claudia, Visser-Wisselaar, Heleen A., Chitu, Dana A, Stevens-Kroef, Marian J.P.L., Coelho, Pedro Silva, Vellenga, Edo, Klein, Saskia K., Wijermans, Pierre W., de Greef, Georgine E., Schaafsma, Martijn R., Kooy, M Marwijk, Muus, Petra, Ossenkoppele, Gert J., Jansen, Joop H., van de Loosdrecht, Arjan A.

“…Myelodysplastic syndromes (MDS) constitute a heterogeneous group of hematopoietic stem cell disorders, characterized by ineffective hematopoiesis resulting in…”
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