Search Results - "Cremer, Marion"

Nuclear compartmentalization, dynamics, and function of regulatory DNA sequences by Cremer, Marion, Cremer, Thomas

“…Transcription regulatory elements (TREs) have been extensively studied on the biochemical level with respect to their interactions with transcription factors…”
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The Interchromatin Compartment Participates in the Structural and Functional Organization of the Cell Nucleus by Cremer, Thomas, Cremer, Marion, Hübner, Barbara, Silahtaroglu, Asli, Hendzel, Michael, Lanctôt, Christian, Strickfaden, Hilmar, Cremer, Christoph

“…This article focuses on the role of the interchromatin compartment (IC) in shaping nuclear landscapes. The IC is connected with nuclear pore complexes (NPCs)…”
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The 4D nucleome: Evidence for a dynamic nuclear landscape based on co-aligned active and inactive nuclear compartments by Cremer, Thomas, Cremer, Marion, Hübner, Barbara, Strickfaden, Hilmar, Smeets, Daniel, Popken, Jens, Sterr, Michael, Markaki, Yolanda, Rippe, Karsten, Cremer, Christoph

“…Recent methodological advancements in microscopy and DNA sequencing-based methods provide unprecedented new insights into the spatio-temporal relationships…”
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Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions by Lanctôt, Christian, Cremer, Thomas, Cheutin, Thierry, Cremer, Marion, Cavalli, Giacomo

“…The regulation of gene expression is mediated by interactions between chromatin and protein complexes. The importance of where and when these interactions take…”
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The potential of 3D-FISH and super-resolution structured illumination microscopy for studies of 3D nuclear architecture by Markaki, Yolanda, Smeets, Daniel, Fiedler, Susanne, Schmid, Volker J., Schermelleh, Lothar, Cremer, Thomas, Cremer, Marion

“…Three‐dimensional structured illumination microscopy (3D‐SIM) has opened up new possibilities to study nuclear architecture at the ultrastructural level down…”
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Cohesin depleted cells rebuild functional nuclear compartments after endomitosis by Cremer, Marion, Brandstetter, Katharina, Maiser, Andreas, Rao, Suhas S. P., Schmid, Volker J., Guirao-Ortiz, Miguel, Mitra, Namita, Mamberti, Stefania, Klein, Kyle N., Gilbert, David M., Leonhardt, Heinrich, Cardoso, M. Cristina, Aiden, Erez Lieberman, Harz, Hartmann, Cremer, Thomas

“…Cohesin plays an essential role in chromatin loop extrusion, but its impact on a compartmentalized nuclear architecture, linked to nuclear functions, is less…”
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True-to-scale DNA-density maps correlate with major accessibility differences between active and inactive chromatin by Gelléri, Márton, Chen, Shih-Ya, Hübner, Barbara, Neumann, Jan, Kröger, Ole, Sadlo, Filip, Imhoff, Jorg, Hendzel, Michael J., Cremer, Marion, Cremer, Thomas, Strickfaden, Hilmar, Cremer, Christoph

“…Chromatin compaction differences may have a strong impact on accessibility of individual macromolecules and macromolecular assemblies to their DNA target…”
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Fluorescence in situ hybridization applications for super-resolution 3D structured illumination microscopy by Markaki, Yolanda, Smeets, Daniel, Cremer, Marion, Schermelleh, Lothar

“…Fluorescence in situ hybridization on three-dimensionally preserved cells (3D-FISH) is an efficient tool to analyze the subcellular localization and spatial…”
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Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci by Smeets, Daniel, Markaki, Yolanda, Schmid, Volker J, Kraus, Felix, Tattermusch, Anna, Cerase, Andrea, Sterr, Michael, Fiedler, Susanne, Demmerle, Justin, Popken, Jens, Leonhardt, Heinrich, Brockdorff, Neil, Cremer, Thomas, Schermelleh, Lothar, Cremer, Marion

“…A Xist RNA decorated Barr body is the structural hallmark of the compacted inactive X territory in female mammals. Using super-resolution three-dimensional…”
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Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters by Cremer, Marion, Schmid, Volker J, Kraus, Felix, Markaki, Yolanda, Hellmann, Ines, Maiser, Andreas, Leonhardt, Heinrich, John, Sam, Stamatoyannopoulos, John, Cremer, Thomas

“…The association of active transcription regulatory elements (TREs) with DNAse I hypersensitivity (DHS[+]) and an 'open' local chromatin configuration has long…”
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Chromosome Order in HeLa Cells Changes during Mitosis and Early G1, but Is Stably Maintained during Subsequent Interphase Stages by Walter, Joachim, Schermelleh, Lothar, Cremer, Marion, Tashiro, Satoshi, Cremer, Thomas

“…Whether chromosomes maintain their nuclear positions during interphase and from one cell cycle to the next has been controversially discussed. To address this…”
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Evolutionary Conservation of Chromosome Territory Arrangements in Cell Nuclei from Higher Primates by Tanabe, Hideyuki, Müller, Stefan, Neusser, Michaela, von Hase, Johann, Calcagno, Enzo, Cremer, Marion, Solovei, Irina, Cremer, Christoph, Cremer, Thomas

“…We demonstrate that the nuclear topological arrangement of chromosome territories (CTs) has been conserved during primate evolution over a period of about 30…”
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Chromatin domains and the interchromatin compartment form structurally defined and functionally interacting nuclear networks by Albiez, Heiner, Cremer, Marion, Tiberi, Cinzia, Vecchio, Lorella, Schermelleh, Lothar, Dittrich, Sandra, Küpper, Katrin, Joffe, Boris, Thormeyer, Tobias, Hase, Johann von, Yang, Siwei, Rohr, Karl, Leonhardt, Heinrich, Solovei, Irina, Cremer, Christoph, Fakan, Stanislav, Cremer, Thomas

“…In spite of strong evidence that the nucleus is a highly organized organelle, a consensus on basic principles of the global nuclear architecture has not so far…”
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Inheritance of Gene Density-Related Higher Order Chromatin Arrangements in Normal and Tumor Cell Nuclei by Cremer, Marion, Küpper, Katrin, Wagler, Babett, Wizelman, Leah, Hase, Johann v., Weiland, Yanina, Kreja, Ludwika, Diebold, Joachim, Speicher, Michael R., Cremer, Thomas

“…A gene density-related difference in the radial arrangement of chromosome territories (CTs) was previously described for human lymphocyte nuclei with gene-poor…”
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A top-down analysis of Xa- and Xi-territories reveals differences of higher order structure at ≥ 20 Mb genomic length scales by Teller, Kathrin, Illner, Doris, Thamm, Stefanie, Casas-Delucchi, Corella S., Versteeg, Rogier, Indemans, Mireille, Cremer, Thomas, Cremer, Marion

“…The active and inactive X (Xa;Xi) territory with its seemingly highly compacted Barr body in nuclei of female mammalian cells provide a key example for studies…”
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Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin by Illner, Doris, Zinner, Roman, Handtke, Violet, Rouquette, Jacques, Strickfaden, Hilmar, Lanctôt, Christian, Conrad, Marcus, Seiler, Alexander, Imhof, Axel, Cremer, Thomas, Cremer, Marion

“…Extensive changes of higher order chromatin arrangements can be observed during prometaphase, terminal cell differentiation and cellular senescence…”
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Non-random radial higher-order chromatin arrangements in nuclei of diploid human cells by Cremer, M, von Hase, J, Volm, T, Brero, A, Kreth, G, Walter, J, Fischer, C, Solovei, I, Cremer, C, Cremer, T

“…A quantitative comparison of higher-order chromatin arrangements was performed in human cell types with three-dimensionally (3D) preserved, differently shaped…”
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Spatial and temporal plasticity of chromatin during programmed DNA-reorganization in Stylonychia macronuclear development by Postberg, Jan, Heyse, Katharina, Cremer, Marion, Cremer, Thomas, Lipps, Hans J

“…In this study we exploit the unique genome organization of ciliates to characterize the biological function of histone modification patterns and chromatin…”
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Arrangements of macro- and microchromosomes in chicken cells by Habermann, F A, Cremer, M, Walter, J, Kreth, G, von Hase, J, Bauer, K, Wienberg, J, Cremer, C, Cremer, T, Solovei, I

“…Arrangements of chromosome territories in nuclei of chicken fibroblasts and neurons were analysed employing multicolour chromosome painting, laser confocal…”
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Chromosome territories by Cremer, Thomas, Cremer, Marion

“…Chromosome territories (CTs) constitute a major feature of nuclear architecture. In a brief statement, the possible contribution of nuclear architecture…”
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