Search Results - "Cremer, Isabelle"

Toll-like receptor stimulation in cancer: A pro- and anti-tumor double-edged sword by Dajon, Marion, Iribarren, Kristina, Cremer, Isabelle

“…Abstract Toll-like receptors (TLRs) are a family of transmembrane receptors that recognize various pathogen- and damage-associated molecular pattern molecules…”
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NK Cells in the Human Lungs by Hervier, Baptiste, Russick, Jules, Cremer, Isabelle, Vieillard, Vincent

“…The lung offers one of the largest exchange surfaces of the individual with the elements of the environment. As a place of important interactions between self…”
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TP53, STK11 , and EGFR Mutations Predict Tumor Immune Profile and the Response to Anti-PD-1 in Lung Adenocarcinoma by Biton, Jérôme, Mansuet-Lupo, Audrey, Pécuchet, Nicolas, Alifano, Marco, Ouakrim, Hanane, Arrondeau, Jennifer, Boudou-Rouquette, Pascaline, Goldwasser, François, Leroy, Karen, Goc, Jeremy, Wislez, Marie, Germain, Claire, Laurent-Puig, Pierre, Dieu-Nosjean, Marie-Caroline, Cremer, Isabelle, Herbst, Ronald, Blons, Hélène, Damotte, Diane

“…By unlocking antitumor immunity, antibodies targeting programmed cell death 1 (PD-1) exhibit impressive clinical results in non-small cell lung cancer,…”
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Trial Watch: Immunogenic cell death inducers for anticancer chemotherapy by Pol, Jonathan, Vacchelli, Erika, Aranda, Fernando, Castoldi, Francesca, Eggermont, Alexander, Cremer, Isabelle, Sautès-Fridman, Catherine, Fucikova, Jitka, Galon, Jérôme, Spisek, Radek, Tartour, Eric, Zitvogel, Laurence, Kroemer, Guido, Galluzzi, Lorenzo

“…The term "immunogenic cell death" (ICD) is now employed to indicate a functionally peculiar form of apoptosis that is sufficient for immunocompetent hosts to…”
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Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma by PLATONOVA, Sophia, CHERFILS-VICINI, Julien, FRIDMAN, Wolf-Herman, SAUTES-FRIDMAN, Catherine, CREMER, Isabelle, DAMOTTE, Diane, CROZET, Lucile, VIEILLARD, Vincent, VALIDIRE, Pierre, ANDRE, Pascale, DIEU-NOSJEAN, Marie-Caroline, ALIFANO, Marco, REGNARD, Jean-François

“…Both the innate and adaptive immune systems contribute to tumor immunosurveillance in mice and humans; however, there is a paucity of direct evidence of a role…”
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Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin by REMARK, Romain, ALIFANO, Marco, FLEJOU, Jean-François, GIBAULT, Laure, VERKARRE, Virginie, REGNARD, Jean-François, PAGES, Olivier-Nicolas, OUDARD, Stéphane, MLECNIK, Bernhard, SAUTES-FRIDMAN, Catherine, FRIDMAN, Wolf-Herman, DAMOTTE, Diane, CREMER, Isabelle, LUPO, Audrey, DIEU-NOSJEAN, Marie-Caroline, RIQUET, Marc, CROZET, Lucile, OUAKRIM, Hanane, GOC, Jeremy, CAZES, Aurélie

“…If immune cells are involved in tumor surveillance and have a prognostic impact in most primary tumors, little is known about their significance in metastases…”
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Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors by RUSAKIEWICZ, Sylvie, SEMERARO, Michaela, CHAIGNEAU, Loic, LE BRUN-LY, Valérie, DUBREUIL, Patrice, CREMER, Isabelle, CAIGNARD, Anne, POIRIER-COLAME, Vichnou, CHABA, Kariman, FLAMENT, Caroline, HALAMA, Niels, JÄGER, Dirk, SARABI, Matthieu, EGGERMONT, Alexander, BONVALOT, Sylvie, COMMO, Frédéric, TERRIER, Philippe, OPOLON, Paule, EMILE, Jean-François, COINDRE, Jean-Michel, KROEMER, Guido, CHAPUT, Nathalie, LE CESNE, Axel, DESBOIS, Mélanie, BLAY, Jean-Yves, ZITVOGEL, Laurence, LOCHER, Clara, MENDEZ, Rosa, VIMOND, Nadège, CONCHA, Angel, GARRIDO, Federico, ISAMBERT, Nicolas

“…Cancer immunosurveillance relies on effector/memory tumor-infiltrating CD8(+) T cells with a T-helper cell 1 (TH1) profile. Evidence for a natural killer (NK)…”
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Systemic inflammation, nutritional status and tumor immune microenvironment determine outcome of resected non-small cell lung cancer by Alifano, Marco, Mansuet-Lupo, Audrey, Lococo, Filippo, Roche, Nicolas, Bobbio, Antonio, Canny, Emelyne, Schussler, Olivier, Dermine, Hervé, Régnard, Jean-François, Burroni, Barbara, Goc, Jérémy, Biton, Jérôme, Ouakrim, Hanane, Cremer, Isabelle, Dieu-Nosjean, Marie-Caroline, Damotte, Diane

“…Hypothesizing that nutritional status, systemic inflammation and tumoral immune microenvironment play a role as determinants of lung cancer evolution, the…”
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Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer by Fucikova, Jitka, Moserova, Irena, Urbanova, Linda, Bezu, Lucillia, Kepp, Oliver, Cremer, Isabelle, Salek, Cyril, Strnad, Pavel, Kroemer, Guido, Galluzzi, Lorenzo, Spisek, Radek

“…It is now clear that human neoplasms form, progress, and respond to therapy in the context of an intimate crosstalk with the host immune system. In particular,…”
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Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors by Delahaye, Nicolas F, Rusakiewicz, Sylvie, Martins, Isabelle, Ménard, Cédric, Roux, Stephan, Lyonnet, Luc, Paul, Pascale, Sarabi, Matthieu, Chaput, Nathalie, Semeraro, Michaela, Minard-Colin, Véronique, Poirier-Colame, Vichnou, Chaba, Kariman, Flament, Caroline, Baud, Véronique, Authier, Hélène, Kerdine-Römer, Saadia, Pallardy, Marc, Cremer, Isabelle, Peaudecerf, Laetitia, Rocha, Bénédita, Valteau-Couanet, Dominique, Gutierrez, Javier Celis, Nunès, Jacques A, Commo, Frédéric, Bonvalot, Sylvie, Ibrahim, Nicolas, Terrier, Philippe, Opolon, Paule, Bottino, Cristina, Moretta, Alessandro, Tavernier, Jan, Rihet, Pascal, Coindre, Jean-Michel, Blay, Jean-Yves, Isambert, Nicolas, Emile, Jean-François, Vivier, Eric, Lecesne, Axel, Kroemer, Guido, Zitvogel, Laurence

“…Gastrointestinal stromal tumors can respond to imatinib mesylate therapy owing to its inhibitory action on tumor cells as well as off-target effects on NK…”
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TLR7 promotes tumor progression, chemotherapy resistance, and poor clinical outcomes in non-small cell lung cancer by Chatterjee, Saradiya, Crozet, Lucile, Damotte, Diane, Iribarren, Kristina, Schramm, Catherine, Alifano, Marco, Lupo, Audrey, Cherfils-Vicini, Julien, Goc, Jeremy, Katsahian, Sandrine, Younes, Mohammad, Dieu-Nosjean, Marie Caroline, Fridman, Wolf Herman, Sautès-Fridman, Catherine, Cremer, Isabelle

“…Toll-like receptors (TLR) recognize pathogen molecules and danger-associated signals that stimulate inflammatory processes. TLRs have been studied mainly in…”
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Immune infiltration in human cancer: prognostic significance and disease control by Fridman, Wolf H, Galon, Jérome, Dieu-Nosjean, Marie-Caroline, Cremer, Isabelle, Fisson, Sylvain, Damotte, Diane, Pagès, Franck, Tartour, Eric, Sautès-Fridman, Catherine

“…The interplay between tumors and their immunologic microenvironment is complex and difficult to decipher, but its understanding is of seminal importance for…”
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Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity by Henegar, Corneliu, Tordjman, Joan, Achard, Vincent, Lacasa, Danièle, Cremer, Isabelle, Guerre-Millo, Michèle, Poitou, Christine, Basdevant, Arnaud, Stich, Vladimir, Viguerie, Nathalie, Langin, Dominique, Bedossa, Pierre, Zucker, Jean-Daniel, Clement, Karine

“…Investigations performed in mice and humans have acknowledged obesity as a low-grade inflammatory disease. Several molecular mechanisms have been convincingly…”
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Autophagy Modulation by Viral Infections Influences Tumor Development by Leonardi, Lucas, Sibéril, Sophie, Alifano, Marco, Cremer, Isabelle, Joubert, Pierre-Emmanuel

“…Autophagy is a self-degradative process important for balancing cellular homeostasis at critical times in development and/or in response to nutrient stress…”
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Unraveling the complex interplay between anti-tumor immune response and autoimmunity mediated by B cells and autoantibodies in the era of anti-checkpoint monoclonal antibody therapies by Soussan, Sarah, Pupier, Guilhem, Cremer, Isabelle, Joubert, Pierre-Emmanuel, Sautès-Fridman, Catherine, Fridman, Wolf Herman, Sibéril, Sophie

“…The intricate relationship between anti-tumor immunity and autoimmunity is a complex yet crucial aspect of cancer biology. Tumor microenvironment often…”
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Trial Watch: Peptide-based anticancer vaccines by Pol, Jonathan, Bloy, Norma, Buqué, Aitziber, Eggermont, Alexander, Cremer, Isabelle, Sautès-Fridman, Catherine, Galon, Jérôme, Tartour, Eric, Zitvogel, Laurence, Kroemer, Guido, Galluzzi, Lorenzo

“…Malignant cells express antigens that can be harnessed to elicit anticancer immune responses. One approach to achieve such goal consists in the administration…”
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Polyfunctionality of bona fide resident lung CD69+ natural killer cells by Hervier, Baptiste, MD, PhD, Cremer, Isabelle, PhD, Vieillard, Vincent, PhD

“…In patients with antisynthetase syndrome (aSS)-a rare autoimmune connective tissue disease characterized with interstitial lung disease (ILD) in the…”
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The New Histologic Classification of Lung Primary Adenocarcinoma Subtypes Is a Reliable Prognostic Marker and Identifies Tumors With Different Mutation Status by Mansuet-Lupo, Audrey, MD, Bobbio, Antonio, MD, PhD, Blons, Hélène, PharmD, PhD, Becht, Etienne, Ouakrim, Hanane, Didelot, Audrey, Charpentier, Marie-Christine, MD, Bain, Serge, Marmey, Béatrice, Bonjour, Patricia, Biton, Jérôme, PhD, Cremer, Isabelle, PhD, Dieu-Nosjean, Marie-Caroline, PhD, Sautès-Fridman, Catherine, PhD, Régnard, Jean-François, MD, Laurent-Puig, Pierre, MD, PhD, Alifano, Marco, MD, PhD, FCCP, Damotte, Diane, MD, PhD

“…BACKGROUND Histologic classification of lung adenocarcinoma subtype has a prognostic value in most studies. However, lung adenocarcinoma characteristics differ…”
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Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions by Russick, Jules, Joubert, Pierre-Emmanuel, Gillard-Bocquet, Mélanie, Torset, Carine, Meylan, Maxime, Petitprez, Florent, Dragon-Durey, Marie-Agnes, Marmier, Solenne, Varthaman, Aditi, Josseaume, Nathalie, Germain, Claire, Goc, Jérémy, Dieu-Nosjean, Marie-Caroline, Validire, Pierre, Fournel, Ludovic, Zitvogel, Laurence, Bindea, Gabriela, Lupo, Audrey, Damotte, Diane, Alifano, Marco, Cremer, Isabelle

“…BackgroundNatural killer (NK) cells play a crucial role in tumor immunosurveillance through their cytotoxic effector functions and their capacity to interact…”
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Immune contexture and histological response after neoadjuvant chemotherapy predict clinical outcome of lung cancer patients by Remark, Romain, Lupo, Audrey, Alifano, Marco, Biton, Jerome, Ouakrim, Hanane, Stefani, Alessandro, Cremer, Isabelle, Goc, Jeremy, Régnard, Jean-Francois, Dieu-Nosjean, Marie-Caroline, Damotte, Diane

“…There is now growing evidence that the immune contexture influences cancer progression and clinical outcome of patients with non-small cell lung cancer…”
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