Search Results - "Cremer, Anjali"

Targeting DUBs to degrade oncogenic proteins by Cremer, Anjali, Stegmaier, Kimberly

“…Summary Targeted protein degradation has emerged as a strategy in cancer therapy. Yang et al. discovered that HBX19818, an inhibitor of the deubiquitinase…”
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Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia by Mohr, Sebastian, Doebele, Carmen, Comoglio, Federico, Berg, Tobias, Beck, Julia, Bohnenberger, Hanibal, Alexe, Gabriela, Corso, Jasmin, Ströbel, Philipp, Wachter, Astrid, Beissbarth, Tim, Schnütgen, Frank, Cremer, Anjali, Haetscher, Nadine, Göllner, Stefanie, Rouhi, Arefeh, Palmqvist, Lars, Rieger, Michael A., Schroeder, Timm, Bönig, Halvard, Müller-Tidow, Carsten, Kuchenbauer, Florian, Schütz, Ekkehard, Green, Anthony R., Urlaub, Henning, Stegmaier, Kimberly, Humphries, R. Keith, Serve, Hubert, Oellerich, Thomas

“…The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore…”
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Time’s up: mutation rate and lifespan by Cremer, Anjali, Abplanalp, Wesley T., Rieger, Michael A.

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P1319: TREATMENT WITH MIDOSTAURIN AND OTHER FLT3 TARGETING INHIBITORS IS ASSOCIATED WITH AN INCREASED RISK OF CARDIOVASCULAR ADVERSE EVENTS IN PATIENTS WITH FLT3 MUTATED AML WHO UNDERWENT ALLOGENEIC HCT by Cremer, Anjali, Enssle, Julius C., Pfaff, Saskia, Kouidri, Khouloud, Lang, Fabian, Brandts, Christian, Zeiher, Andreas, Cremer, Sebastian, Steffen, Björn, Serve, Hubert, Bug, Gesine

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Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations by Bensinger, Dennis, Stubba, Daniel, Cremer, Anjali, Kohl, Vanessa, Waßmer, Theresa, Stuckert, Johanna, Engemann, Victoria, Stegmaier, Kimberly, Schmitz, Katja, Schmidt, Boris

“…The use of covalent irreversible binding inhibitors is an established concept for drug development. Usually, the discovery of new irreversible kinase…”
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The proteogenomic subtypes of acute myeloid leukemia by Jayavelu, Ashok Kumar, Wolf, Sebastian, Buettner, Florian, Alexe, Gabriela, Häupl, Björn, Comoglio, Federico, Schneider, Constanze, Doebele, Carmen, Fuhrmann, Dominik C., Wagner, Sebastian, Donato, Elisa, Andresen, Carolin, Wilke, Anne C., Zindel, Alena, Jahn, Dominique, Splettstoesser, Bianca, Plessmann, Uwe, Münch, Silvia, Abou-El-Ardat, Khali, Makowka, Philipp, Acker, Fabian, Enssle, Julius C., Cremer, Anjali, Schnütgen, Frank, Kurrle, Nina, Chapuy, Björn, Löber, Jens, Hartmann, Sylvia, Wild, Peter J., Wittig, Ilka, Hübschmann, Daniel, Kaderali, Lars, Cox, Jürgen, Brüne, Bernhard, Röllig, Christoph, Thiede, Christian, Steffen, Björn, Bornhäuser, Martin, Trumpp, Andreas, Urlaub, Henning, Stegmaier, Kimberly, Serve, Hubert, Mann, Matthias, Oellerich, Thomas

“…Acute myeloid leukemia (AML) is an aggressive blood cancer with a poor prognosis. We report a comprehensive proteogenomic analysis of bone marrow biopsies from…”
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Interventional Antibiotic Treatment Replacing Antibiotic Prophylaxis during Allogeneic Hematopoietic Stem Cell Transplantation Is Safe and Feasible: A Single-Center Analysis by Toenges, Rosa, Lang, Fabian, Ghaffar, Rakhshinda, Schlipfenbacher, Vera, Riemann, Julia, Ajib, Salem, Kouidri, Khouloud, Cremer, Anjali, Bodo, Weber, Nguyen, Thu, Knoch, Antje, Vehreschild, Janne, Serve, Hubert, Bug, Gesine

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SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia by Schneider, Constanze, Oellerich, Thomas, Baldauf, Hanna-Mari, Schwarz, Sarah-Marie, Thomas, Dominique, Flick, Robert, Bohnenberger, Hanibal, Kaderali, Lars, Stegmann, Lena, Cremer, Anjali, Martin, Margarethe, Lohmeyer, Julian, Michaelis, Martin, Hornung, Veit, Schliemann, Christoph, Berdel, Wolfgang E, Hartmann, Wolfgang, Wardelmann, Eva, Comoglio, Federico, Hansmann, Martin-Leo, Yakunin, Alexander F, Geisslinger, Gerd, Ströbel, Philipp, Ferreirós, Nerea, Serve, Hubert, Keppler, Oliver T, Cinatl, Jindrich

“…The therapeutic response of acute myeloid leukemia to the nucleoside analog Ara-C is controlled by SAMHD1, an enzyme that hydrolyzes the active metabolite…”
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Engineering of potent CAR NK cells using non-viral Sleeping Beauty transposition from minimalistic DNA vectors by Bexte, Tobias, Botezatu, Lacramioara, Miskey, Csaba, Gierschek, Fenja, Moter, Alina, Wendel, Philipp, Reindl, Lisa Marie, Campe, Julia, Villena-Ossa, Jose Francisco, Gebel, Veronika, Stein, Katja, Cathomen, Toni, Cremer, Anjali, Wels, Winfried S, Hudecek, Michael, Ivics, Zoltán, Ullrich, Evelyn

“…Natural killer (NK) cells have high intrinsic cytotoxic capacity, and clinical trials have demonstrated their safety and efficacy for adoptive cancer therapy…”
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Interventional antibiotic treatment replacing antibiotic prophylaxis during allogeneic hematopoietic stem cell transplantation is safe and leads to a reduction of antibiotic administration by Toenges, Rosa, Lang, Fabian, Ghaffar, Rakhshinda, Lindner, Sarah, Schlipfenbacher, Vera, Riemann, Julia, Ajib, Salem, Kouidri, Khouloud, Cremer, Anjali, Weber, Bodo, Nguyen, Ngoc Thien Thu, Knoch, Antje, Vehreschild, Janne, Serve, Hubert, Bug, Gesine

“…Patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT) face an elevated risk of infection-related mortality, particularly during the…”
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SARS‐CoV‐2‐specific T cells are generated in less than half of allogeneic HSCT recipients failing to seroconvert after COVID‐19 vaccination by Jarisch, Andrea, Wiercinska, Eliza, Daqiq‐Mirdad, Shabnam, Hellstern, Helen, Ajib, Salem, Cremer, Anjali, Nguyen, Ngoc Thien Thu, Dukat, Alexandra, Ullrich, Evelyn, Ciesek, Sandra, Chow, Kai‐Uwe, Serve, Hubert, Seifried, Erhard, Bader, Peter, Bonig, Halvard, Bug, Gesine

“…Little is known about the cellular immune response to SARS‐CoV‐2 vaccination in patients after HSCT and B‐NHL with iatrogenic B‐cell aplasia. In…”
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Treatment with midostaurin and other FLT3 targeting inhibitors is associated with an increased risk of cardiovascular adverse events in patients who underwent allogeneic hematopoietic stem cell transplantation with FLT3-mutated AML by Cremer, Anjali, Enssle, Julius C., Pfaff, Saskia, Kouidri, Khouloud, Lang, Fabian, Brandts, Christian, Zeiher, Andreas, Cremer, Sebastian, Steffen, Björn, Serve, Hubert, Bug, Gesine

“…The addition of midostaurin to standard chemotherapy has improved survival in patients with FLT3 -mutated AML. However, the impact of midostaurin and other…”
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Proteomic Characterization of Acute Myeloid Leukemia by Wolf, Sebastian, Jayavelu, Ashok Kumar, Buettner, Florian, Alexe, Gabriela, Häupl, Björn, Schneider, Constanze, Wilke, Anne C, Zindel, Alena, Jahn, Dominique, Splettstoesser, Bianca, Enssle, Julius Christoph, Cremer, Anjali, Röllig, Christoph, Thiede, Christian, Steffen, Björn, Bornhäuser, Martin, Urlaub, Henning, Stegmaier, Kimberly, Serve, Hubert, Mann, Matthias, Oellerich, Thomas

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FLT3-ITD and TLR9 use Bruton tyrosine kinase to activate distinct transcriptional programs mediating AML cell survival and proliferation by Oellerich, Thomas, Mohr, Sebastian, Corso, Jasmin, Beck, Julia, Döbele, Carmen, Braun, Helene, Cremer, Anjali, Münch, Silvia, Wicht, Johannes, Oellerich, Mark F., Bug, Gesine, Bohnenberger, Hanibal, Perske, Christina, Schütz, Ekkehard, Urlaub, Henning, Serve, Hubert

“…Acute myeloid leukemia (AML) is driven by niche-derived and cell-autonomous stimuli. Although many cell-autonomous disease drivers are known, niche-dependent…”
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Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia by Cremer, Anjali, Ellegast, Jana M, Alexe, Gabriela, Frank, Elizabeth S, Ross, Linda, Chu, S Haihua, Pikman, Yana, Robichaud, Amanda, Goodale, Amy, Häupl, Björn, Mohr, Sebastian, Rao, Arati V, Walker, Alison R, Blachly, James S, Piccioni, Federica, Armstrong, Scott A, Byrd, John C, Oellerich, Thomas, Stegmaier, Kimberly

“…Spleen tyrosine kinase (SYK) is a nonmutated therapeutic target in acute myeloid leukemia (AML). Attempts to exploit SYK therapeutically in AML have shown…”
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Resistance Mechanisms to SYK Inhibition in AML by Cremer, Anjali, Ellegast, Jana M, Pikman, Yana, Alexe, Gabriela, Ross, Linda, Goodale, Amy, Piccioni, Federica, Frank, Elizabeth S, Oellerich, Thomas, Stegmaier, Kimberly

“…Alterations in signaling pathways are critical to the pathogenesis of acute myeloid leukemia (AML) and are often driven by aberrant kinases. We previously…”
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IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia by Aubrey, Brandon J, Cutler, Jevon A, Bourgeois, Wallace, Donovan, Katherine A, Gu, Shengqing, Hatton, Charlie, Perlee, Sarah, Perner, Florian, Rahnamoun, Homa, Theall, Alexandra C P, Henrich, Jill A, Zhu, Qian, Nowak, Radosław P, Kim, Young Joon, Parvin, Salma, Cremer, Anjali, Olsen, Sarah Naomi, Eleuteri, Nicholas A, Pikman, Yana, McGeehan, Gerard M, Stegmaier, Kimberly, Letai, Anthony, Fischer, Eric S, Liu, X Shirley, Armstrong, Scott A

“…Acute myeloid leukemia (AML) remains difficult to treat and requires new therapeutic approaches. Potent inhibitors of the chromatin-associated protein MENIN…”
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Diagnostic Yield and Outcomes of Computed Tomography of the Head in Critically Ill Nontrauma Patients by Finkelmeier, Fabian, Walter, Sophie, Peiffer, Kai-Henrik, Cremer, Anjali, Tal, Andrea, Vogl, Thomas, Zeuzem, Stefan, Fichtlscherer, Stephan, Friedrich-Rust, Mireen, Bojunga, Jörg, Farnik, Harald

“…Background: Computed tomography of the head (HCT) is a widely used diagnostic tool, especially for emergency and trauma patients. However, the diagnostic yield…”
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Abstract 50: Elucidation of B cell receptor signaling in Burkitt's lymphoma reveals novel signaling nodes with potential therapeutic relevance by Doebele, Carmen, Corso, Jasmin, Cremer, Anjali, Muench, Silvia, Beck, Julia, Lenz, Christof, Bohnenberger, Hanibal, Wachter, Astrid, Beissbarth, Tim, Schütz, Ekkehard, Serve, Hubert, Urlaub, Henning, Oellerich, Thomas

“…Abstract B cell antigen receptors (BCR) control important cell fate decisions of the B-lineage including differentiation, proliferation and B cell survival…”
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Correction: Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia by Schneider, Constanze, Oellerich, Thomas, Baldauf, Hanna-Mari, Schwarz, Sarah-Marie, Thomas, Dominique, Flick, Robert, Bohnenberger, Hanibal, Kaderali, Lars, Stegmann, Lena, Cremer, Anjali, Martin, Margarethe, Lohmeyer, Julian, Michaelis, Martin, Hornung, Veit, Schliemann, Christoph, Berdel, Wolfgang E, Hartmann, Wolfgang, Wardelmann, Eva, Comoglio, Federico, Hansmann, Martin-Leo, Yakunin, Alexander F, Geisslinger, Gerd, Ströbel, Philipp, Ferreirós, Nerea, Serve, Hubert, Keppler, Oliver T, Cinatl, Jindrich

“…Nat. Med. 23, 250–255 (2017); published online 19 December 2016; corrected after print 18 April 2017 In the version of this article initially published, the…”
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