Search Results - "Crellin, A."

The Road Map for National Health Service Proton Beam Therapy by Crellin, A.

“…Proton Beam Therapy is one of the key elements in a major improvement in access to advanced radiotherapy in the UK. An overseas programme has treated…”
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The Road Map for Proton Therapy: Reply to Professor Karol Sikora by Crellin, A.

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Developing a National Infrastructure for Proton Beam Therapy Trials by Rieu, R., Crellin, A., Thomson, D., Nutting, C.

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Redundant microtubule crosslinkers prevent meiotic spindle bending to ensure diploid offspring in C. elegans by Li, Wenzhe, Crellin, Helena A, Cheerambathur, Dhanya, McNally, Francis J

“…Oocyte meiotic spindles mediate the expulsion of ¾ of the genome into polar bodies to generate diploid zygotes in nearly all animal species. Failures in this…”
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Outcomes of Patients Treated in the UK Proton Overseas Programme: Central Nervous System Group by Gaito, S., Hwang, E.J., France, A., Aznar, M.C., Burnet, N., Crellin, A., Holtzman, A.L., Indelicato, D.J., Timmerman, B., Whitfield, G.A., Smith, E.

“…In 2008, the UK National Health Service started the Proton Overseas Programme (POP), to provide access for proton beam therapy (PBT) abroad for selected tumour…”
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Outcomes of Patients Treated in the UK Proton Overseas Programme: Non-central Nervous System Group by Hwang, E., Gaito, S., France, A., Crellin, A.M., Thwaites, D.I., Ahern, V., Indelicato, D., Timmermann, B., Smith, E.

“…The UK Proton Overseas Programme (POP) was launched in 2008. The Proton Clinical Outcomes Unit (PCOU) warehouses a centralised registry for collection,…”
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Assessing Equity of Access to Proton Beam Therapy: A Literature Review by Gaito, S., Aznar, M.C., Burnet, N.G., Crellin, A., France, A., Indelicato, D., Kirkby, K.J., Pan, S., Whitfield, G., Smith, E.

“…Proton beam therapy (PBT) is one of the most advanced radiotherapy technologies, with growing evidence to support its use in specific clinical scenarios and…”
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A Novel Model and Infrastructure for Clinical Outcomes Data Collection and Their Systematic Evaluation for UK Patients Receiving Proton Beam Therapy by Hwang, E., Burnet, N.G., Crellin, A.M., Ahern, V., Thwaites, D.I., Gaito, S., Chang, Y.-C., Smith, E.

“…To establish an infrastructure for sustainable, comprehensive data collection and systematic outcomes evaluation for UK patients receiving proton beam therapy…”
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Normal Tissue Complication Probability Modelling for Toxicity Prediction and Patient Selection in Proton Beam Therapy to the Central Nervous System: A Literature Review by Gaito, S., Burnet, N., Aznar, M., Crellin, A., Indelicato, D.J., Ingram, S., Pan, S., Price, G., Hwang, E., France, A., Smith, E., Whitfield, G.

“…Normal tissue complication probability (NTCP) models can guide clinical decision making in radiotherapy. In recent years, they have been used for patient…”
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Revalidation and Lifelong Learning by Crellin, A

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Proton Beam Therapy in the Reirradiation Setting of Brain and Base of Skull Tumour Recurrences by Gaito, S., Burnet, N.G., Aznar, M.C., Marvaso, G., Jereczek-Fossa, B.A., Crellin, A., Indelicato, D., Pan, S., Colaco, R., Rieu, R., Smith, E., Whitfield, G.

“…The therapeutic management of local tumour recurrence after a first course of radical radiotherapy is always complex. Surgery and reirradiation carry increased…”
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Wide Variation in the Use of Radiotherapy in the Management of Surgically Treated Rectal Cancer Across the English National Health Service by Morris, E.J.A, Finan, P.J, Spencer, K, Geh, I, Crellin, A, Quirke, P, Thomas, J.D, Lawton, S, Adams, R, Sebag-Montefiore, D

“…Abstract Aims Radiotherapy is an important treatment modality in the multidisciplinary management of rectal cancer. It is delivered both in the neoadjuvant…”
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Hypofractionated Radiotherapy in Oesophageal Cancer for Patients Unfit for Systemic Therapy: A Retrospective Single-Centre Analysis by Jones, C.M., Spencer, K., Hitchen, C., Pelly, T., Wood, B., Hatfield, P., Crellin, A., Sebag-Montefiore, D., Goody, R., Crosby, T., Radhakrishna, G.

“…Chemoradiotherapy (CRT) is established as a superior treatment option to definitive radiotherapy in the non-surgical management of oesophageal cancer. For…”
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Caution is required in the implementation of 90-day mortality indicators for radiotherapy in a curative setting: A retrospective population-based analysis of over 16,000 episodes by Spencer, K., Ellis, R., Birch, R., Dugdale, E., Turner, R., Sebag-Montefiore, D., Hall, G., Crellin, A., Morris, E.

“…90-day mortality (90DM) has been proposed as a clinical indicator in radiotherapy delivered in a curative setting. No large scale assessment has been made. Its…”
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Preoperative (neoadjuvant) chemoradiotherapy in oesophageal cancer by Geh, J. I., Crellin, A. M., Glynne-Jones, R.

“…Background Oesophageal cancer carries a poor prognosis. The 5‐year survival rate following resection ranges from 10 to 35 per cent. Recent evidence suggests…”
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Analysis of a National Programme for Selective Internal Radiation Therapy for Colorectal Cancer Liver Metastases by White, J., Carolan-Rees, G., Dale, M., Morgan, H.E., Patrick, H.E., See, T.C., Beeton, E.L., Swinson, D.E.B., Bell, J.K., Manas, D.M., Crellin, A., Slevin, N.J., Sharma, R.A.

“…Patients with chemotherapy-refractory colorectal cancer liver metastases have limited therapeutic options. Selective internal radiation therapy (SIRT) delivers…”
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Proton Beam Therapy: The Context, Future Direction and Challenges Become Clearer by Crellin, A.M, Burnet, N.G

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Superiority of Deformable Image Co-registration in the Integration of Diagnostic Positron Emission Tomography-Computed Tomography to the Radiotherapy Treatment Planning Pathway for Oesophageal Carcinoma by Ward, G, Ramasamy, S, Sykes, J.R, Prestwich, R, Chowdhury, F, Scarsbrook, A, Murray, P, Harris, K, Crellin, A, Hatfield, P, Sebag-Montefiore, D, Spezi, E, Crosby, T, Radhakrishna, G

“…Abstract Aims To investigate the use of image co-registration in incorporating diagnostic positron emission tomography-computed tomography (PET-CT) directly…”
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Upregulation of the Human Alkaline Ceramidase 1 and Acid Ceramidase Mediates Calcium-Induced Differentiation of Epidermal Keratinocytes by Sun, Wei, Xu, Ruijuan, Hu, Wei, Jin, Junfei, Crellin, Heather A., Bielawski, Jacek, Szulc, Zdzislaw M., Thiers, Bruce H., Obeid, Lina M., Mao, Cungui

“…Extracellular calcium (Cao2+) potently induces the growth arrest and differentiation of human epidermal keratinocytes (HEKs). We report that Cao2+ markedly…”
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Waiting for radiotherapy by Dodwell, D, Crellin, A

“…Amid recent improvements in cancer care within the United Kingdom, inadequate radiotherapy capacity compromises care and is an important and underappreciated…”
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