Search Results - "Crego, Antonio L"

Design of strategies to study the metabolic profile of highly polar compounds in plasma by reversed-phase liquid chromatography–high resolution mass spectrometry by Sánchez-López, Elena, Crego, Antonio L., Marina, María Luisa

“…•For the first time FMOC is used to label plasma in LC–MS.•A larger number of FMOC compounds retained in RPLC than underivatized in HILIC.•Ultrafiltration (UF)…”
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Improving the sensitivity in chiral capillary electrophoresis by Sánchez‐López, Elena, Marina, María Luisa, Crego, Antonio L

“…CE is known for being one of the most powerful analytical techniques when performing enantioseparations due to its numerous advantages such as excellent…”
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The effects of combined intravenous cocaine and ethanol self-administration on the behavioral and amino acid profile of young adult rats by Marcos, Alberto, Moreno, Mario, Orihuel, Javier, Ucha, Marcos, Mª de Paz, Ana, Higuera-Matas, Alejandro, Capellán, Roberto, Crego, Antonio L, Martínez-Larrañaga, María-Rosa, Ambrosio, Emilio, Anadón, Arturo

“…Under paradigms of combined intravenous cocaine and ethanol self-administration, the effects on behavior have been poorly explored. Numerous studies have found…”
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Enantiomeric separation of FMOC-amino acids by nano-LC and CEC using a new chiral stationary phase, cellulose tris(3-chloro-4-methylphenylcarbamate) by Domínguez-Vega, Elena, Crego, Antonio L., Lomsadze, Ketevan, Chankvetadze, Bezhan, Marina, Maria L.

“…A novel polysaccharide‐based chiral stationary phase (CSP), cellulose tris(3‐chloro‐4‐methylphenylcarbamate), also known as Sepapak‐2 or Lux Cellulose‐2, has…”
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New approaches in sensitive chiral CE by Sánchez-Hernández, Laura, Guijarro-Diez, Miguel, Marina, María Luisa, Crego, Antonio L.

“…CE has shown to have a big potential for chiral separations, with advantages such as high efficiency, high resolution, and low sample and reagents consumption…”
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Metabolic fingerprinting of chemotherapy-resistant prostate cancer stem cells. An untargeted metabolomic approach by liquid chromatography-mass spectrometry by Bort, Alicia, G. Sánchez, Belén, León, Carlos, Nozal, Leonor, Mora-Rodríguez, José M., Castro, Florentina, Crego, Antonio L., Díaz-Laviada, Inés

“…Chemoresistance is one of the most important challenges in cancer therapy. The presence of cancer stem cells within the tumor may contribute to chemotherapy…”
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Determination of l- and d-carnitine in dietary food supplements using capillary electrophoresis–tandem mass spectrometry by Sánchez-Hernández, Laura, Castro-Puyana, María, García-Ruiz, Carmen, Crego, Antonio L., Marina, Maria Luisa

“…This paper reports the application of a capillary electrophoresis–electrospray ionisation-tandem mass spectrometry methodology for the unequivocal…”
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About the role of enantioselective selector-selectand interactions and the mobilities of diastereomeric associates in enantiomer separations using CE by Lomsadze, Ketevan, Martínez-Girón, Ana B, Castro-Puyana, María, Chankvetadze, Lali, Crego, Antonio L, Salgado, Antonio, Marina, María Luisa, Chankvetadze, Bezhan

“…It is generally accepted that the selective binding of enantiomers of the chiral analyte to a chiral selector is necessary for enantioseparations in CE,…”
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Enantiomeric separation of chiral polycyclic musks by capillary electrophoresis: Application to the analysis of cosmetic samples by Martínez-Girón, Ana Belén, Crego, Antonio L., González, Maria José, Marina, Maria Luisa

“…The enantiomeric separation of four chiral polycyclic musks (Galaxolide, Tonalide, Traseolide and Phantolide) using CE was achieved for the first time in this…”
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Development of an in-capillary derivatization method by CE for the determination of chiral amino acids in dietary supplements and wines by Martínez-Girón, Ana Belén, García-Ruiz, Carmen, Crego, Antonio L, Marina, Maria Luisa

“…A fast in-capillary derivatization method by CE with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate was developed for the first time for the determination of…”
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Development of a CE-ESI-ITMS method for the enantiomeric determination of the non-protein amino acid ornithine by Domínguez-Vega, Elena, Sánchez-Hernández, Laura, García-Ruiz, Carmen, Crego, Antonio L, Marina, Maria Luisa

“…Unequivocal enantiomeric determination by CE-MS² of the non-protein amino acid ornithine (Orn), previously derivatized with FITC, was carried out in this work…”
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Untargeted metabolomic study by liquid chromatography–mass spectrometry in brain tissues on the effects of combined cocaine and ethanol self-administration in male and female young rats by Marcos, Alberto, León, Carlos, Moreno-Fernández, Mario, Castro-Rubio, Florentina, Garrido-Matilla, Lucia, Nozal, Leonor, Ambrosio, Emilio, Crego, Antonio L.

“…•Cocaine and ethanol self-administration induces a brain with sexodimorphic pattern.•Cocaine and ethanol self-administration altered brain purine and…”
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Automated open-access liquid chromatography high resolution mass spectrometry to support drug discovery projects by Fontana, Alberto, Iturrino, Laura, Corens, David, Crego, Antonio L.

“…•An Automated Open-Access UHPLC- QTOF system has been developed for medicinal chemistry samples.•End users log-in samples with Universal Open-Access LC-MS…”
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Enantiomeric separation of ornithine in complex mixtures of amino acids by EKC with off-line derivatization with 6-aminoquinolyl- N-hydroxysuccinimidyl carbamate by Martínez-Girón, Ana Belén, Domínguez-Vega, Elena, García-Ruiz, Carmen, Crego, Antonio L., Marina, Maria Luisa

“…A new analytical methodology was developed by EKC enabling the fast enantiomeric separation of Ornithine in complex mixtures of amino acids. A previous…”
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Untargeted metabolomic analysis to explore the impact of soil amendments in a non-conventional wastewater treatment by Huidobro-López, Blanca, León, Carlos, López-Heras, Isabel, Martínez-Hernández, Virtudes, Nozal, Leonor, Crego, Antonio L., de Bustamante, Irene

“…As non-conventional wastewater treatment, vegetation filters make the most of the natural attenuation processes that occur in soil to remove contaminants,…”
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Enantioseparation of the constituents involved in the phenylalanine-tyrosine metabolic pathway by capillary electrophoresis tandem mass spectrometry by Sánchez-López, Elena, Marcos, Alberto, Ambrosio, Emilio, Marina, María Luisa, Crego, Antonio L.

“…•A CE-ESI–MS2 method is developed to determine Phe-Tyr metabolic pathway enantiomers.•First simultaneous enantioseparation of the constituents of this…”
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Simultaneous separation of epinephrine and norepinephrine enantiomers by EKC: Application to the analysis of pharmaceutical formulations by Castro-Puyana, María, Drewnowska, Renata, Pérez-Fernández, Virginia, Ángeles García, María, Crego, Antonio L, Marina, María Luisa

“…A new analytical methodology using EKC with a CD as chiral selector was developed enabling the simultaneous enantiomeric separation of two chiral…”
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Chiral separation of a basic drug with two chiral centers by electrokinetic chromatography for its pharmaceutical development by Martínez-Girón, Ana Belén, Marina, María Luisa, Crego, Antonio L.

“…•CE method to separate four stereoisomers of a drug development as single enantiomer.•Two in-capillary preconcentration techniques allow sensitivity gains of…”
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Development of chiral methodologies by capillary electrophoresis with ultraviolet and mass spectrometry detection for duloxetine analysis in pharmaceutical formulations by Sánchez-López, Elena, Montealegre, Cristina, Marina, María Luisa, Crego, Antonio L.

“…•For the first time, duloxetine enantiomers are analyzed in pharmaceuticals by CE.•Two CE methodologies with UV and MS detection were developed and…”
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first contribution of capillary electrophoresis to the study of abiotic origins of homochirality: Investigation of the enantioselective adsorption of 3-carboxy adipic acid on minerals by Castro-Puyana, María, Salgado, Antonio, Hazen, Robert M, Crego, Antonio L, Alegre, María Luisa Marina

“…CE with UV detection was used for the first time to determine the enantioselective adsorption of the short-chain tricarboxylic acid, 3-carboxy adipic acid, on…”
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