Search Results - "Creemers, L"

Nanoghosts: Mesenchymal Stem cells derived nanoparticles as a unique approach for cartilage regeneration by D'Atri, D., Zerrillo, L., Garcia, J., Oieni, J., Lupu-Haber, Y., Schomann, T., Chan, A., Cruz, L.J., Creemers, L.B., Machluf, Marcelle

“…Osteoarthritis (OA) is a chronic degenerative disease, which affects the joints and is characterized by inflammation, cartilage loss and bone changes…”
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The role of altered glycosylation in human nucleus pulposus cells in inflammation and degeneration by Joyce, K, Mohd Isa, I L, Krouwels, A, Creemers, L, Devitt, A, Pandit, A

“…Intervertebral disc (IVD) degeneration causes low-back pain through disc compression, prolapse and herniation. Inflammation of the IVD and subsequent…”
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Intradiscal delivery of celecoxib-loaded microspheres restores intervertebral disc integrity in a preclinical canine model by Tellegen, A.R., Rudnik-Jansen, I., Beukers, M., Miranda-Bedate, A., Bach, F.C., de Jong, W., Woike, N., Mihov, G., Thies, J.C., Meij, B.P., Creemers, L.B., Tryfonidou, M.A.

“…Low back pain, related to degeneration of the intervertebral disc (IVD), affects millions of people worldwide. Clinical studies using oral cyclooxygenase-2…”
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Noggin inhibits TGF-β1 OR TGF-β3 induced chondrogenesis of mesenchymal stromal cells by Wen, L, Armiento, AR, Guex, AG, Grad, S, Creemers, L, Stoddart, MJ

“…Noggin (NOG) is an antagonist of bone morphogenetic proteins (BMPs), which regulates development and homeostasis of bone and cartilage. NOG has also been…”
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Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes by Vonk, L.A, Kragten, A.H.M, Dhert, W.J.A, Saris, D.B.F, Creemers, L.B

“…Summary Objective Hsa-miR-148a expression is decreased in Osteoarthritis (OA) cartilage, but its functional role in cartilage has never been studied…”
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The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs by Bach, F C, de Vries, S A H, Krouwels, A, Creemers, L B, Ito, K, Meij, B P, Tryfonidou, M A

“…During intervertebral disc (IVD) maturation, the main cell type shifts from notochordal cells (NCs) to chondrocyte-like cells (CLCs). NCs secrete factors with…”
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Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: potential associations with aging and degeneration by Rutges, J, Creemers, L.B, Dhert, W, Milz, S, Sakai, D, Mochida, J, Alini, M, Grad, S

“…Summary Objective Regardless of recent progress in the elucidation of intervertebral disc (IVD) degeneration, the basic molecular characteristics that define a…”
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Efficacy of one-stage cartilage repair using allogeneic mesenchymal stromal cells and autologous chondron transplantation (IMPACT) compared to nonsurgical treatment for focal articular cartilage lesions of the knee: study protocol for a crossover randomized controlled trial by Korpershoek, J V, Vonk, L A, Kester, E C, Creemers, L B, de Windt, T S, Kip, M M A, Saris, D B F, Custers, R J H

“…Articular cartilage defects in the knee have poor intrinsic healing capacity and may lead to functional disability and osteoarthritis (OA). "Instant MSC…”
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Evaluation of histological scoring systems for tissue-engineered, repaired and osteoarthritic cartilage by Rutgers, M, van Pelt, M.J.P, Dhert, W.J.A, Creemers, L.B, Saris, D.B.F

“…Summary Objective Regeneration of hyaline cartilage has been the focus of an increasing number of research groups around the world. One of the most important…”
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Controlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis by Tellegen, A. R., Rudnik-Jansen, I., Pouran, B., de Visser, H. M., Weinans, H. H., Thomas, R. E., Kik, M. J. L., Grinwis, G. C. M., Thies, J. C., Woike, N., Mihov, G., Emans, P. J., Meij, B. P., Creemers, L. B., Tryfonidou, M. A.

“…Major hallmarks of osteoarthritis (OA) are cartilage degeneration, inflammation and osteophyte formation. COX-2 inhibitors counteract inflammation-related…”
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Sustained release of locally delivered celecoxib provides pain relief for osteoarthritis: a proof of concept in dog patients by Tellegen, A.R., Rudnik-Jansen, I., Utomo, L., Versteeg, S., Beukers, M., Maarschalkerweerd, R., van Zuilen, D., van Klaveren, N.J., Houben, K., Teske, E., van Weeren, P.R., Karssemakers-Degen, N., Mihov, G., Thies, J., Eijkelkamp, N., Creemers, L.B., Meij, B.P., Tryfonidou, M.A.

“…Drug delivery platforms that allow for gradual drug release after intra-articular administration have become of much interest as a treatment strategy for…”
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An explorative study comparing levels of soluble mediators in control and osteoarthritic synovial fluid by Beekhuizen, M, Gierman, L.M, van Spil, W.E, Van Osch, G.J.V.M, Huizinga, T.W.J, Saris, D.B.F, Creemers, L.B, Zuurmond, A.-M

“…Summary Objective Soluble mediators in synovial fluid (SF) are acknowledged as key players in the pathophysiology of osteoarthritis (OA). However, a…”
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A validated new histological classification for intervertebral disc degeneration by Rutges, J.P.H.J, Duit, R.A, Kummer, J.A, Bekkers, J.E.J, Oner, F.C, Castelein, R.M, Dhert, W.J.A, Creemers, L.B

“…Summary Histology is an important outcome variable in basic science and pre-clinical studies regarding intervertebral disc degeneration (IVD). Nevertheless, an…”
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Biomaterials for intervertebral disc regeneration: past performance and possible future strategies by Schutgens, E M, Tryfonidou, M A, Smit, T H, Öner, F C, Krouwels, A, Ito, K, Creemers, L B

“…Intervertebral disc (IVD) degeneration is associated with most cases of cervical and lumbar spine pathologies, amongst which chronic low back pain has become…”
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Soluble and pelletable factors in porcine, canine and human notochordal cell-conditioned medium: implications for IVD regeneration by Bach, F C, de Vries, S A, Riemers, F M, Boere, J, van Heel, F W, van Doeselaar, M, Goerdaya, S S, Nikkels, P G, Benz, K, Creemers, L B, Maarten Altelaar, A F, Meij, B P, Ito, K, Tryfonidou, M A

“…During intervertebral disc (IVD) maturation, notochordal cells (NCs) are replaced by chondrocyte-like cells (CLCs) in the nucleus pulposus, suggesting that NCs…”
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Notochordal cell-derived matrix inhibits MAPK signaling in the degenerative disc environment by Laagland, LT, Bach, FC, Riemers, FM, Erdmann, G, Braun, TS, van den Akker, GGH, Schmitz, TC, Creemers, LB, Sachse, C, Le Maitre, CL, Welting, TJM, Ito, K, Templin, MF, Tryfonidou, MA

“…Chronic low back pain is often caused by intervertebral disc (IVD) degeneration. Preceding this degenerative process, the main cellular phenotype in the…”
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Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels by Rutges, JPHJ, Kummer, JA, Oner, FC, Verbout, AJ, Castelein, RJM, Roestenburg, HJA, Dhert, WJA, Creemers, LB

“…Intervertebral disc (IVD) degeneration is associated with the increased expression of several matrix metalloproteinases (MMPs), in particular MMP-2. However,…”
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Isolation and purification of type A spermatogonia from the bovine testis by Izadyar, F, Spierenberg, GT, Creemers, LB, den Ouden, K, de Rooij, DG

“…The aim of this study was to isolate and purify bovine type A spermatogonia. Testes from 5-7-month-old calves were used to isolate germ cells using a two-step…”
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Articular Cartilage Degeneration Following the Treatment of Focal Cartilage Defects with Ceramic Metal Implants and Compared with Microfracture by Custers, R.J.H, Saris, D.B.F, Dhert, W.J.A, Verbout, A.J, van Rijen, M.H.P, Mastbergen, S.C, Lafeber, F.P.J.G, Creemers, L.B

“…BackgroundLocalized cartilage defects are frequently associated with joint pain, reduced function, and a predisposition to the development of osteoarthritis…”
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Hypertrophic differentiation and calcification during intervertebral disc degeneration by Rutges, J.P.H.J, Duit, R.A, Kummer, J.A, Oner, F.C, van Rijen, M.H, Verbout, A.J, Castelein, R.M, Dhert, W.J.A, Creemers, L.B

“…Summary Background In degenerative intervertebral discs (IVDs) collagen type X expression and calcifications have been demonstrated, resembling advanced…”
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