Search Results - "Creemers, John W. M"

PCSK1 Mutations and Human Endocrinopathies: From Obesity to Gastrointestinal Disorders by Stijnen, Pieter, Ramos-Molina, Bruno, O'Rahilly, Stephen, Creemers, John W. M

“…Prohormone convertase 1/3, encoded by the PCSK1 gene, is a serine endoprotease that is involved in the processing of a variety of proneuropeptides and…”
Get full text

Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone by Declercq, Jeroen, Brouwers, Bas, Pruniau, Vincent P E G, Stijnen, Pieter, de Faudeur, Geoffroy, Tuand, Krizia, Meulemans, Sandra, Serneels, Lutgarde, Schraenen, Anica, Schuit, Frans, Creemers, John W M

“…The Nestin-Cre driver mouse line has mild hypopituitarism, reduced body weight, a metabolic phenotype and reduced anxiety. Although several causes have been…”
Get full text

The proprotein convertase furin in cancer: more than an oncogene by He, Zongsheng, Khatib, Abdel-Majid, Creemers, John W. M.

“…Furin is the first discovered proprotein convertase member and is present in almost all mammalian cells. Therefore, by regulating the maturation of a wide…”
Get full text

Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity by CREEMERS, John W. M, CHOQUET, Helene, BALKAU, Beverley, ELLIOTT, Paul, JARVELIN, Marjo-Riitta, HUL, Wim Van, GAAL, Luc Van, HORBER, Fritz, PATTOU, François, FROGUEL, Philippe, MEYRE, David, STIJNEN, Pieter, VATIN, Vincent, PIGEYRE, Marie, BECKERS, Sigri, MEULEMANS, Sandra, THAN, Manuel E, YENGO, Loïc, TAUBER, Maithe

“…Null mutations in the PCSK1 gene, encoding the proprotein convertase 1/3 (PC1/3), cause recessive monogenic early onset obesity. Frequent coding variants that…”
Get full text

The dwarf phenotype in GH240B mice, haploinsufficient for the autism candidate gene Neurobeachin, is caused by ectopic expression of recombinant human growth hormone by Nuytens, Kim, Tuand, Krizia, Fu, Quili, Stijnen, Pieter, Pruniau, Vincent, Meulemans, Sandra, Vankelecom, Hugo, Creemers, John W M

“…Two knockout mouse models for the autism candidate gene Neurobeachin (Nbea) have been generated independently. Although both models have similar phenotypes,…”
Get full text

Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D by Jansen, Silvia, Stefan, Cristiana, Creemers, John W. M, Waelkens, Etienne, Van Eynde, Aleyde, Stalmans, Willy, Bollen, Mathieu

“…Autotaxin (NPP2) is an extracellular protein that is upregulated in various malignancies, including breast and lung cancer. It potently stimulates cell…”
Get full text

Curbing activation: proprotein convertases in homeostasis and pathology by Taylor, Neil A., Van De Ven, Wim J. M., Creemers, John W. M.

“…ABSTRACT The proprotein convertases (PCs) are a seven‐member family of endoproteases that activate proproteins by cleavage at basic motifs. Expression patterns…”
Get full text

SCAMP5, NBEA and AMISYN: three candidate genes for autism involved in secretion of large dense-core vesicles by Castermans, Dries, Volders, Karolien, Crepel, An, Backx, Liesbeth, De Vos, Rita, Freson, Kathleen, Meulemans, Sandra, Vermeesch, Joris R., Schrander-Stumpel, Connie T.R.M., De Rijk, Peter, Del-Favero, Jurgen, Van Geet, Chris, Van De Ven, Wim J.M., Steyaert, Jean G., Devriendt, Koen, Creemers, John W.M.

“…Autism is a neurodevelopmental disorder characterized by impaired social reciprocity, impaired communication and stereotypical behaviors. Despite strong…”
Get full text

The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer by He, Zongsheng, Thorrez, Lieven, Siegfried, Geraldine, Meulemans, Sandra, Evrard, Serge, Tejpar, Sabine, Khatib, Abdel-Majid, Creemers, John W. M.

“…Mutations in KRAS and/or BRAF that activate the ERK kinase are frequently found in colorectal cancer (CRC) and drive resistance to targeted therapies…”
Get full text

Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic β Cells of Mice by Coppola, Ilaria, Brouwers, Bas, Meulemans, Sandra, Ramos-Molina, Bruno, Creemers, John W M

“…The insulin receptor (IR) is critically involved in maintaining glucose homeostasis. It undergoes proteolytic cleavage by proprotein convertases, which is an…”
Get full text

Identification and characterization of the TRIP8 and REEP3 genes on chromosome 10q21.3 as novel candidate genes for autism by CASTERMANS, Dries, VERMEESCH, Joris R, FRYNS, Jean-Pierre, STEYAERT, Jean G, VAN DE VEN, Wim J. M, CREEMERS, John W. M, DEVRIENDT, Koen

“…Autism is a genetic neurodevelopmental disorder of unknown cause and pathogenesis. The identification of genes involved in autism is expected to increase our…”
Get full text

Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer by He, Zongsheng, Khatib, Abdel-Majid, Creemers, John W. M.

“…In triple negative breast cancer (TNBC) cell lines, the proprotein convertase Furin cleaves and then activates several protein precursors involved in…”
Get full text

PREPL deficiency with or without cystinuria causes a novel myasthenic syndrome by Régal, Luc, Shen, Xin-Ming, Selcen, Duygu, Verhille, Chantal, Meulemans, Sandra, Creemers, John W.M, Engel, Andrew G

“…OBJECTIVE:To investigate the genetic and physiologic basis of the neuromuscular symptoms of hypotonia-cystinuria syndrome (HCS) and isolated PREPL deficiency,…”
Get full text

Hyperphagia and Early-Onset Obesity due to a Novel Homozygous Missense Mutation in Prohormone Convertase 1/3 by Farooqi, I. Sadaf, Volders, Karolien, Stanhope, Richard, Heuschkel, Robert, White, Anne, Lank, Emma, Keogh, Julia, O’Rahilly, Stephen, Creemers, John W. M.

“…Context: Congenital deficiency of the neuroendocrine-specific enzyme prohormone convertase (PC) 1/3 leads to a syndrome characterized by obesity, small…”
Get full text

The Association of Common Variants in PCSK1 With Obesity: A HuGE Review and Meta-Analysis by STIJNEN, Pieter, TUAND, Krizia, VARGA, Tibor V, FRANKS, Paul W, AERTGEERTS, Bert, CREEMERS, John W. M

“…Congenital deficiency of the proprotein convertase subtilisine/kexin type 1 gene (PCSK1), which encodes proprotein convertase 1/3, causes a severe…”
Get full text

Loss of Furin in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction by Brouwers, Bas, Coppola, Ilaria, Vints, Katlijn, Dislich, Bastian, Jouvet, Nathalie, Van Lommel, Leentje, Segers, Charlotte, Gounko, Natalia V, Thorrez, Lieven, Schuit, Frans, Lichtenthaler, Stefan F, Estall, Jennifer L, Declercq, Jeroen, Ramos-Molina, Bruno, Creemers, John W M

“…FURIN is a proprotein convertase (PC) responsible for proteolytic activation of a wide array of precursor proteins within the secretory pathway. It maps to the…”
Get full text

Common nonsynonymous variants in PCSK1 confer risk of obesity by Lobbens, Stephane, Guerardel, Audrey, Borch-Johnsen, Knut, Lauritzen, Torsten, Froguel, Philippe, Potoczna, Natascha, Marre, Michel, Heude, Barbara, Jacobson, Peter, Meyre, David, Jouret, Beatrice, Czernichow, Sebastien, Benzinou, Michael, Durand, Emmanuelle, Kovacs, Peter, Boutin, Philippe, Walley, Andrew J, Choquet, Helene, Sandbaek, Annelli, Körner, Antje, Hansen, Torben, Andersen, Gitte, Creemers, John W M, Jørgensen, Torben, Pedersen, Oluf, Le Stunff, Catherine, Carlsson, Lena M S, Horber, Fritz, Dina, Christian, Kiess, Wieland, Tichet, Jean, Balkau, Beverley

“…Philippe Froguel and colleagues report that common nonsynonymous variants in PCSK1 , encoding a prohormone convertase, confer risk of obesity in individuals of…”
Get full text

In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23 by Al Rifai, Omar, Susan-Resiga, Delia, Essalmani, Rachid, Creemers, John W M, Seidah, Nabil G, Ferron, Mathieu

“…Fibroblast growth factor 23 (FGF23) is a hormone secreted from fully differentiated osteoblasts and osteocytes that inhibits phosphate reabsorption by kidney…”
Get full text

Decidual Differentiation of Stromal Cells Promotes Proprotein Convertase 5/6 Expression and Lefty Processing by Tang, Meiyi, Mikhailik, Anatoly, Pauli, Ilse, Giudice, Linda C, Fazelabas, Asgerally T, Tulac, Suzana, Carson, Daniel D, Kaufman, David G, Barbier, Claire, Creemers, John W. M, Tabibzadeh, Siamak

“…Lefty/Ebaf polypeptides, novel members of the TGF-β superfamily, are involved in endometrial differentiation and embryo implantation. Recently, we showed that,…”
Get full text

Loss of Endothelial Furin Leads to Cardiac Malformation and Early Postnatal Death by Kim, WooJin, Essalmani, Rachid, Szumska, Dorota, Creemers, John W M, Roebroek, Anton J M, D'Orleans-Juste, Pedro, Bhattacharya, Shoumo, Seidah, Nabil G, Prat, Annik

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text